Identification |
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Name: | Betaine aldehyde dehydrogenase |
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Synonyms: | |
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Gene Name: | betB |
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Enzyme Class: | |
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Biological Properties |
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General Function: | Involved in oxidoreductase activity |
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Specific Function: | Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH |
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Cellular Location: | Not Available |
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SMPDB Pathways: | Not Available |
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KEGG Pathways: | - Glycine, serine and threonine metabolism ec00260
- Metabolic pathways eco01100
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KEGG Reactions: | |
1.0 | + | 1.0 | + | 1.0 | → | 1.0 | + | 2.0 | + | 1.0 |
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1.0 | + | 1.0 | + | 1.0 | ↔ | 1.0 | + | 2.0 | + | 1.0 |
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1.0 | + | 1.0 | + | 1.0 | ↔ | 1.0 | + | 1.0 | + | 2.0 |
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1.0 | + | 1.0 | + | 1.0 | → | 1.0 | + | 1.0 | + | 1.0 |
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EcoCyc Reactions: | |
1.0 | + | 1.0 | + | 1.0 | ↔ | 1.0 | + | 2.0 | + | 1.0 |
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1.0 | + | 1.0 | + | 1.0 | → | 1.0 | + | 1.0 | + | 1.0 |
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Complex Reactions: | |
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Metabolites: | |
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GO Classification: | Function |
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betaine-aldehyde dehydrogenase activity | catalytic activity | oxidoreductase activity | oxidoreductase activity, acting on the aldehyde or oxo group of donors | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | Process |
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betaine biosynthetic process | betaine metabolic process | cellular amino acid and derivative metabolic process | cellular amino acid derivative metabolic process | cellular biogenic amine metabolic process | cellular metabolic process | metabolic process | oxidation reduction |
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Gene Properties |
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Blattner: | b0312 |
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Gene Orientation | Counterclockwise |
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Centisome Percentage: | 7.04 |
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Left Sequence End | 326485 |
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Right Sequence End | 327957 |
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Gene Sequence: | >1473 bp
ATGTCCCGAATGGCAGAACAGCAGCTTTATATACATGGTGGTTATACCTCCGCCACCAGC
GGTCGCACCTTCGAGACCATTAACCCGGCCAACGGTAACGTGCTGGCGACCGTGCAGGCC
GCCGGGCGCGAGGATGTCGATCGCGCCGTGAAAAGCGCCCAGCAGGGGCAAAAAATCTGG
GCGTCGATGACCGCCATGGAGCGCTCGCGTATTCTGCGTCGGGCCGTTGATATTCTGCGT
GAACGCAATGACGAACTCGCAAAACTGGAAACCCTCGACACCGGAAAAGCATATTCGGAA
ACCTCAACCGTCGATATCGTTACCGGTGCGGACGTGCTGGAGTACTACGCCGGGCTGATC
CCGGCGCTGGAAGGCAGCCAGATCCCGTTGCGTGAAACGTCCTTTGTGTATACCCGCCGC
GAACCGCTGGGCGTAGTGGCAGGGATTGGCGCATGGAACTACCCGATCCAGATTGCCCTG
TGGAAATCCGCCCCGGCGCTGGCGGCAGGCAACGCAATGATTTTCAAACCGAGCGAAGTT
ACCCCGCTTACCGCGTTAAAGCTGGCTGAAATTTACAGCGAAGCGGGCCTGCCGGACGGC
GTATTTAACGTGTTGCCGGGCGTGGGCGCGGAGACCGGGCAATATCTGACCGAGCATCCG
GGCATTGCCAAAGTGTCATTTACCGGCGGTGTCGCCAGCGGCAAAAAAGTGATGGCTAAC
TCGGCGGCCTCTTCCCTGAAAGAAGTGACCATGGAACTGGGCGGTAAATCACCGCTGATC
GTTTTCGATGATGCGGATCTCGATCTCGCCGCCGATATCGCCATGATGGCAAACTTCTTC
AGCTCCGGTCAGGTGTGTACCAATGGCACCCGCGTCTTCGTTCCGGCGAAATGCAAAGCC
GCATTTGAGCAGAAAATTCTGGCGCGCGTTGAGCGCATTCGCGCGGGCGACGTTTTCGAT
CCGCAAACTAACTTCGGCCCGCTGGTCAGCTTCCCGCATCGCGATAACGTGCTGCGCTAT
ATCGCCAAAGGCAAAGAGGAAGGCGCGCGCGTACTGTGCGGCGGCGATGTACTGAAAGGC
GATGGCTTCGATAACGGCGCATGGGTTGCACCGACAGTGTTCACCGATTGCAGCGACGAT
ATGACCATCGTGCGTGAAGAGATCTTCGGGCCAGTGATGTCCATTCTGACCTACGAGTCG
GAAGACGAAGTCATTCGCCGCGCTAACGATACCGACTACGGCCTGGCGGCGGGCATCGTG
ACAGCGGACCTGAACCGCGCGCATCGCGTCATTCATCAGCTGGAAGCGGGTATTTGCTGG
ATCAACACCTGGGGCGAATCCCCGGCAGAGATGCCCGTTGGCGGCTACAAACACTCCGGC
ATTGGTCGCGAGAACGGCGTGATGACGCTCCAGAGTTACACCCAGGTGAAGTCCATCCAG
GTTGAGATGGCTAAATTCCAGTCCATATTCTAA |
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Protein Properties |
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Pfam Domain Function: | |
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Protein Residues: | 490 |
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Protein Molecular Weight: | 52911 |
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Protein Theoretical pI: | 5 |
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Signaling Regions: | |
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Transmembrane Regions: | |
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Protein Sequence: | >Betaine aldehyde dehydrogenase
MSRMAEQQLYIHGGYTSATSGRTFETINPANGNVLATVQAAGREDVDRAVKSAQQGQKIW
ASMTAMERSRILRRAVDILRERNDELAKLETLDTGKAYSETSTVDIVTGADVLEYYAGLI
PALEGSQIPLRETSFVYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEV
TPLTALKLAEIYSEAGLPDGVFNVLPGVGAETGQYLTEHPGIAKVSFTGGVASGKKVMAN
SAASSLKEVTMELGGKSPLIVFDDADLDLAADIAMMANFFSSGQVCTNGTRVFVPAKCKA
AFEQKILARVERIRAGDVFDPQTNFGPLVSFPHRDNVLRYIAKGKEEGARVLCGGDVLKG
DGFDNGAWVAPTVFTDCSDDMTIVREEIFGPVMSILTYESEDEVIRRANDTDYGLAAGIV
TADLNRAHRVIHQLEAGICWINTWGESPAEMPVGGYKHSGIGRENGVMTLQSYTQVKSIQ
VEMAKFQSIF |
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References |
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External Links: | |
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General Reference: | - Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Boyd, L. A., Adam, L., Pelcher, L. E., McHughen, A., Hirji, R., Selvaraj, G. (1991). "Characterization of an Escherichia coli gene encoding betaine aldehyde dehydrogenase (BADH): structural similarity to mammalian ALDHs and a plant BADH." Gene 103:45-52. Pubmed: 1879697
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
- Lamark, T., Kaasen, I., Eshoo, M. W., Falkenberg, P., McDougall, J., Strom, A. R. (1991). "DNA sequence and analysis of the bet genes encoding the osmoregulatory choline-glycine betaine pathway of Escherichia coli." Mol Microbiol 5:1049-1064. Pubmed: 1956285
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