4-alpha-glucanotransferase (P15977)

Identification
Name:4-alpha-glucanotransferase
Synonyms:
  • Amylomaltase
  • Disproportionating enzyme
  • D-enzyme
Gene Name:malQ
Enzyme Class:
Biological Properties
General Function:Involved in 4-alpha-glucanotransferase activity
Specific Function:Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan
Cellular Location:Cytoplasm
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb
1.01,4-alpha-D-glucan + 1.0D-Glucose ↔ 1.0D-Maltose
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Maltotriose + 1.0D-Maltose ↔ 1.0Maltotetraose + 1.0b-D-Glucose
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0D-Maltose + 1.0Maltotriose → 1.0D-Glucose + 1.0Maltotetraose
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0D-Maltose + 1.0Maltotetraose → 1.0D-Glucose + 1.0Maltopentaose
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0D-Maltose + 1.0Maltohexaose → 1.0D-Glucose + 1.0Maltoheptaose
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0D-Maltose + 1.0Maltopentaose → 1.0D-Glucose + 1.0Maltohexaose
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB211101,4-alpha-D-glucanMetaboCard
ECMDB00516b-D-GlucoseMetaboCard
ECMDB00122D-GlucoseMetaboCard
ECMDB00163D-MaltoseMetaboCard
ECMDB20349MaltoheptaoseMetaboCard
ECMDB21243MaltohexaoseMetaboCard
ECMDB21244MaltopentaoseMetaboCard
ECMDB01296MaltotetraoseMetaboCard
ECMDB01262MaltotrioseMetaboCard
GO Classification:
Function
4-alpha-glucanotransferase activity
binding
catalytic activity
cation binding
glycogen debranching enzyme activity
ion binding
Process
carbohydrate metabolic process
metabolic process
primary metabolic process
Gene Properties
Blattner:b3416
Gene OrientationCounterclockwise
Centisome Percentage:76.43
Left Sequence End3546008
Right Sequence End3548092
Gene Sequence:
>2085 bp
ATGGAAAGCAAACGTCTGGATAATGCCGCGCTGGCGGCGGGGATTAGCCCCAATTACATC
AATGCCCACGGTAAACCGCAGTCGATTAGCGCCGAAACCAAACGGCGTTTGCTTGACGCG
ATGCATCAACGTACCGCCACGAAAGTGGCGGTAACGCCAGTCCCGAATGTCATGGTTTAT
ACCAGCGGCAAAAAAATGCCGATGGTGGTGGAGGGCAGCGGCGAATATAGCTGGCTGCTG
ACCACCGAAGAAGGAACGCAGTACAAAGGCCATGTAACGGGGGGCAAAGCGTTCAATCTA
CCGACGAAGCTGCCGGAAGGTTATCACACGCTGACACTCACCCAGGACGACCAGCGCGCG
CATTGCCGGGTGATTGTCGCCCCGAAACGCTGTTACGAACCGCAGGCGTTGCTGAATAAA
CAAAAGCTGTGGGGTGCCTGCGTTCAGCTTTATACGCTGCGATCGGAAAAAAACTGGGGT
ATTGGGGATTTTGGCGATCTCAAAGCGATGCTGGTGGATGTGGCAAAACGTGGCGGGTCG
TTCATTGGCCTGAACCCGATTCATGCGCTCTATCCGGCAAATCCGGAGAGCGCCAGCCCA
TACAGCCCGTCTTCTCGCCGTTGGCTGAATGTGATTTATATCGACGTTAACGCCGTTGAA
GATTTCCATCTTAGCGAAGAGGCTCAGGCCTGGTGGCAGTTGCCGACCACGCAACAGACG
CTGCAACAGGCGCGCGATGCCGACTGGGTCGATTACTCCACGGTTACCGCCCTAAAAATG
ACAGCATTACGAATGGCGTGGAAAGGTTTCGCGCAACGTGATGATGAGCAGATGGCCGCG
TTTCGCCAGTTTGTTGCAGAGCAGGGCGACAGCCTGTTCTGGCAGGCAGCCTTTGATGCG
CTACATGCCCAGCAAGTGAAAGAGGACGAAATGCGCTGGGGCTGGCCTGCATGGCCAGAG
ATGTATCAGAACGTGGATTCACCAGAAGTGCGTCAGTTCTGCGAAGAACATCGTGATGAC
GTCGATTTTTATCTCTGGTTGCAGTGGCTGGCTTACAGCCAGTTTGCCGCCTGCTGGGAG
ATAAGCCAGGGCTATGAAATGCCGATTGGCTTGTATCGTGATCTGGCGGTTGGCGTAGCG
GAAGGTGGGGCGGAAACCTGGTGTGACCGTGAACTATATTGCCTGAAAGCATCGGTTGGC
GCGCCGCCGGATATCCTCGGCCCGTTGGGGCAGAACTGGGGATTACCGCCAATGGACCCG
CATATCATCACCGCGCGTGCCTATGAACCGTTTATCGAGCTGTTGCGTGCCAATATGCAA
AACTGCGGCGCATTACGAATTGACCATGTGATGTCGATGCTGCGTTTGTGGTGGATACCG
TATGGCGAGACGGCAGATCAGGGCGCGTATGTTCACTATCCGGTGGATGATCTGCTCTCG
ATTCTGGCACTCGAAAGTAAACGTCATCGCTGTATGGTGATTGGTGAAGATCTCGGTACC
GTACCGGTAGAGATTGTCGGTAAGCTGCGCAGCAGCGGTGTGTACTCTTACAAAGTGCTC
TATTTCGAAAACGACCACGAGAAGACGTTCCGTGCACCGAAAGCGTATCCGGAGCAGTCG
ATGGCGGTTGCGGCGACACATGACCTGCCAACGCTGCGCGGTTACTGGGAGTGCGGGGAT
CTAACGCTGGGCAAAACCCTGGGGCTGTATCCGGATGAAGTGGTACTGCGCGGTCTGTAT
CAGGATCGCGAACTGGCGAAGCAAGGGCTGCTGGATGCACTGCATAAATATGGTTGTCTG
CCGAAACGTGCCGGGCATAAGGCATCGTTGATGTCGATGACGCCGACGCTGAACCGTGGT
TTGCAGCGCTACATTGCCGACAGTAACAGTGCTCTGTTAGGACTACAGCCGGAAGACTGG
CTGGATATGGCCGAACCGGTGAATATTCCTGGCACCAGTTACCAGTATAAAAACTGGCGA
CGCAAGCTTTCCGCAACGCTTGAGTCGATGTTTGCCGATGATGGCGTGAACAAGTTGCTG
AAGGATTTGGACAGACGGCGCAGAGCTGCAGCGAAGAAGAAGTAG
Protein Properties
Pfam Domain Function:
Protein Residues:694
Protein Molecular Weight:78503
Protein Theoretical pI:7
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>4-alpha-glucanotransferase
MESKRLDNAALAAGISPNYINAHGKPQSISAETKRRLLDAMHQRTATKVAVTPVPNVMVY
TSGKKMPMVVEGSGEYSWLLTTEEGTQYKGHVTGGKAFNLPTKLPEGYHTLTLTQDDQRA
HCRVIVAPKRCYEPQALLNKQKLWGACVQLYTLRSEKNWGIGDFGDLKAMLVDVAKRGGS
FIGLNPIHALYPANPESASPYSPSSRRWLNVIYIDVNAVEDFHLSEEAQAWWQLPTTQQT
LQQARDADWVDYSTVTALKMTALRMAWKGFAQRDDEQMAAFRQFVAEQGDSLFWQAAFDA
LHAQQVKEDEMRWGWPAWPEMYQNVDSPEVRQFCEEHRDDVDFYLWLQWLAYSQFAACWE
ISQGYEMPIGLYRDLAVGVAEGGAETWCDRELYCLKASVGAPPDILGPLGQNWGLPPMDP
HIITARAYEPFIELLRANMQNCGALRIDHVMSMLRLWWIPYGETADQGAYVHYPVDDLLS
ILALESKRHRCMVIGEDLGTVPVEIVGKLRSSGVYSYKVLYFENDHEKTFRAPKAYPEQS
MAVAATHDLPTLRGYWECGDLTLGKTLGLYPDEVVLRGLYQDRELAKQGLLDALHKYGCL
PKRAGHKASLMSMTPTLNRGLQRYIADSNSALLGLQPEDWLDMAEPVNIPGTSYQYKNWR
RKLSATLESMFADDGVNKLLKDLDRRRRAAAKKK
References
External Links:
ResourceLink
Uniprot ID:P15977
Uniprot Name:MALQ_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85676625
Ecogene ID:EG10561
Ecocyc:EG10561
ColiBase:b3416
Kegg Gene:b3416
EchoBASE ID:EB0556
CCDB:MALQ_ECOLI
BacMap:16131292
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Pugsley, A. P., Dubreuil, C. (1988). "Molecular characterization of malQ, the structural gene for the Escherichia coli enzyme amylomaltase." Mol Microbiol 2:473-479. Pubmed: 2845225