| Identification |
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| Name: | Chromate reductase |
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| Synonyms: | Not Available |
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| Gene Name: | chrR |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | xenobiotic metabolic process |
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| Specific Function: | Involved in the protection against chromate toxicity. Catalyzes the transfer of three electrons to Cr(6+) producing Cr(3+) and one electron to molecular oxygen without producing the toxic Cr(5+) species and only producing a minimal amount of reactive oxygen species (ROS). It can also reduce quinones, potassium ferricyanide, 2,6-dichloroindophenol, V(5+), Mo(6+), methylene blue and cytochrome c. The quinone reductase activity may protect against oxidative stress by preventing redox cycling of quinones which would otherwise generate ROS and by maintaining a pool of reduced quinone in the cell that is able to quench ROS directly. It is able to use both NAD or NADP equally well. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | - Ubiquinone and other terpenoid-quinone biosynthesis ec00130
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| KEGG Reactions: | |
1.0 | + | 1.0 | + | 1.0 | + | 1.0 | ↔ | 1.0 | + | 1.0 | + | 1.0 |
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| Metabolites: | |
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| GO Classification: | | Function |
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| FMN binding | | NAD(P)H dehydrogenase (quinone) activity | | oxidoreductase activity | | xenobiotic metabolic process |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >567
atgtctgaaaaattgcaggtggttacgttactggggagcctgcgcaaaggctcatttaat
ggcatggttgcacgtaccctgccgaaaattgctccggcgagcatggaagtcaatgcgtta
ccatccattgccgacattcccttgtatgacgctgacgtacagcaggaagaaggttttcca
gcaacggttgaagctctggcggaacagatccgtcaggctgacggtgtggtgatcgtcacg
ccggaatataactactcggtaccgggtgggctgaaaaatgccatcgactggctttcccgc
ctgccggatcaaccgctggccggtaaaccggtattgattcagaccagctcaatgggcgtg
attggcggcgcgcgctgtcagtatcacctgcgccagattctggttttcctcgatgcaatg
gtgatgaacaagccggaatttatgggcggcgtgattcagaacaaagttgatccgcaaacc
ggagaagtgattgatcagggtacgctggaccacctgaccgggcaattgaccgcatttggt
gagtttattcagcgagttaagatctaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 188 |
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| Protein Molecular Weight: | 20375 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 3SVL |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Chromate reductase
MSEKLQVVTLLGSLRKGSFNGMVARTLPKIAPASMEVNALPSIADIPLYDADVQQEEGFP
ATVEALAEQIRQADGVVIVTPEYNYSVPGGLKNAIDWLSRLPDQPLAGKPVLIQTSSMGV
IGGARCQYHLRQILVFLDAMVMNKPEFMGGVIQNKVDPQTGEVIDQGTLDHLTGQLTAFG
EFIQRVKI |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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