ECMDB: Chromate reductase (P0AGE6)

Identification

Name:

Chromate reductase

Synonyms:

Not Available

Gene Name:

chrR

Enzyme Class:

1.6.5.2

Biological Properties

General Function:

xenobiotic metabolic process

Specific Function:

Involved in the protection against chromate toxicity. Catalyzes the transfer of three electrons to Cr(6+) producing Cr(3+) and one electron to molecular oxygen without producing the toxic Cr(5+) species and only producing a minimal amount of reactive oxygen species (ROS). It can also reduce quinones, potassium ferricyanide, 2,6-dichloroindophenol, V(5+), Mo(6+), methylene blue and cytochrome c. The quinone reductase activity may protect against oxidative stress by preventing redox cycling of quinones which would otherwise generate ROS and by maintaining a pool of reduced quinone in the cell that is able to quench ROS directly. It is able to use both NAD or NADP equally well.

Cellular Location:

Not Available

SMPDB Pathways:

Not Available

KEGG Pathways:

Ubiquinone and other terpenoid-quinone biosynthesis ec00130

KEGG Reactions:

1.0

↔

1.0

1.0NADH + 1.0NADPH + 1.0Hydrogen ion + 1.0Quinone ↔ 1.0NAD + 1.0NADP + 1.0Hydroquinone
ReactionCard

Metabolites:

ECMDB ID	Name	View

GO Classification:

Function
FMN binding
NAD(P)H dehydrogenase (quinone) activity
oxidoreductase activity
xenobiotic metabolic process

Gene Properties

Blattner:

Not Available

Gene Orientation

Not Available

Centisome Percentage:

Not Available

Left Sequence End

Not Available

Right Sequence End

Not Available

Gene Sequence:

>567
atgtctgaaaaattgcaggtggttacgttactggggagcctgcgcaaaggctcatttaat
ggcatggttgcacgtaccctgccgaaaattgctccggcgagcatggaagtcaatgcgtta
ccatccattgccgacattcccttgtatgacgctgacgtacagcaggaagaaggttttcca
gcaacggttgaagctctggcggaacagatccgtcaggctgacggtgtggtgatcgtcacg
ccggaatataactactcggtaccgggtgggctgaaaaatgccatcgactggctttcccgc
ctgccggatcaaccgctggccggtaaaccggtattgattcagaccagctcaatgggcgtg
attggcggcgcgcgctgtcagtatcacctgcgccagattctggttttcctcgatgcaatg
gtgatgaacaagccggaatttatgggcggcgtgattcagaacaaagttgatccgcaaacc
ggagaagtgattgatcagggtacgctggaccacctgaccgggcaattgaccgcatttggt
gagtttattcagcgagttaagatctaa

Protein Properties

Pfam Domain Function:

Not Available

Protein Residues:

188

Protein Molecular Weight:

20375

Protein Theoretical pI:

Not Available

PDB File:

3SVL

Signaling Regions:

Not Available

Transmembrane Regions:

Not Available

Protein Sequence:

>Chromate reductase
MSEKLQVVTLLGSLRKGSFNGMVARTLPKIAPASMEVNALPSIADIPLYDADVQQEEGFP
ATVEALAEQIRQADGVVIVTPEYNYSVPGGLKNAIDWLSRLPDQPLAGKPVLIQTSSMGV
IGGARCQYHLRQILVFLDAMVMNKPEFMGGVIQNKVDPQTGEVIDQGTLDHLTGQLTAFG
EFIQRVKI

References

External Links:

Resource	Link
Uniprot ID:	P0AGE6
Uniprot Name:	CHRR_ECOLI
PDB ID:	3SVL
CCDB:	CHRR_ECOLI

General Reference:

Not Available