Identification |
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Name: | Glyoxylate carboligase |
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Synonyms: | - Tartronate-semialdehyde synthase
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Gene Name: | gcl |
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Enzyme Class: | |
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Biological Properties |
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General Function: | Involved in tartronate-semialdehyde synthase activity |
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Specific Function: | Catalyzes the condensation of two molecules of glyoxylate to give 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) |
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Cellular Location: | Not Available |
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SMPDB Pathways: | - glycolate and glyoxylate degradation PW000827
- glycolate and glyoxylate degradation II PW002021
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KEGG Pathways: | - Glyoxylate and dicarboxylate metabolism ec00630
- Metabolic pathways eco01100
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KEGG Reactions: | |
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SMPDB Reactions: | |
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EcoCyc Reactions: | |
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Complex Reactions: | |
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Metabolites: | |
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GO Classification: | Function |
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binding | carbon-carbon lyase activity | carboxy-lyase activity | catalytic activity | cation binding | ion binding | lyase activity | magnesium ion binding | metal ion binding | tartronate-semialdehyde synthase activity | thiamin pyrophosphate binding | vitamin binding | Process |
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aldehyde catabolic process | cellular aldehyde metabolic process | cellular metabolic process | glyoxylate catabolic process | metabolic process |
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Gene Properties |
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Blattner: | b0507 |
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Gene Orientation | Clockwise |
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Centisome Percentage: | 11.49 |
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Left Sequence End | 533140 |
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Right Sequence End | 534921 |
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Gene Sequence: | >1782 bp
ATGCGTAGTTTTAGCCAACTGTGGCCGACTCTCAAGCGCCTGTTAGCGTACGGTTCGCCG
TGGCGTAAACCGCTGGGGATTGCGGTCCTGATGATGTGGGTTGCGGCGGCGGCAGAAGTC
AGTGGGCCGCTGCTTATCAGCTATTTTATCGACAATATGGTAGCGAAAAATAACCTGCCG
TTGAAAGTGGTTGCAGGGCTGGCTGCGGCGTATGTTGGGCTGCAACTGTTTGCCGCCGGG
CTACATTACGCGCAGTCGCTGCTGTTTAATCGGGCGGCAGTAGGCGTAGTGCAACAGTTG
CGTACCGACGTGATGGATGCTGCGTTACGCCAGCCATTAAGCGAGTTTGATACCCAACCC
GTCGGGCAGGTGATTTCCCGCGTCACTAATGACACTGAAGTGATCCGCGATCTCTACGTT
ACCGTAGTGGCAACTGTCCTGCGCAGTGCCGCGCTGGTGGGCGCGATGCTGGTGGCGATG
TTCAGCCTCGACTGGCGAATGGCACTGGTGGCGATAATGATTTTCCCGGTGGTGCTGGTG
GTAATGGTGATATACCAGCGTTACAGCACGCCGATTGTCCGTCGTGTGCGCGCCTATTTG
GCGGATATCAACGACGGCTTTAACGAAATCATCAATGGCATGAGCGTTATCCAGCAGTTT
CGTCAGCAGGCGCGATTTGGCGAACGTATGGGGGAGGCCAGTCGTTCACACTATATGGCG
AGGATGCAAACCCTGCGCCTCGACGGTTTTCTGCTGCGTCCGCTGCTGAGTCTGTTTTCA
TCGCTCATTCTTTGTGGCTTGTTGATGCTGTTTGGCTTCTCCGCCAGCGGCACCATTGAA
GTGGGCGTGCTGTATGCGTTTATCAGCTATCTTGGGCGACTTAACGAACCATTAATCGAA
CTGACCACGCAACAGGCGATGCTGCAACAGGCTGTTGTTGCTGGTGAGCGCGTGTTTGAA
CTGATGGACGGACCGCGCCAGCAATATGGCAATGATGATCGCCCGTTACAGAGTGGCACC
ATCGAAGTCGATAACGTGTCATTTGCTTATCGCGATGACAATCTGGTGCTAAAGAACATT
AATCTCTCTGTGCCTTCGCGCAATTTTGTGGCGCTGGTCGGGCATACCGGCAGTGGCAAA
AGCACCCTCGCCAGTTTATTGATGGGCTATTACCCGCTAACGGAAGGTGAGATTCGCCTT
GATGGTCGTCCATTAAGTTCGCTAAGTCACAGCGCGCTGCGCCAGGGCGTGGCAATGGTG
CAGCAAGATCCGGTGGTGCTGGCGGATACCTTCCTCGCCAACGTGACGCTGGGGCGGGAT
ATCTCCGAAGAACGCGTCTGGCAGGCGCTGGAAACCGTGCAACTGGCGGAGCTGGCGCGT
AGCATGAGCGACGGTATTTACACGCCGCTGGGCGAGCAGGGGAATAATCTCTCAGTTGGG
CAAAAGCAACTGCTGGCACTGGCGCGCGTGCTGGTCGAGACGCCGCAAATCCTGATCCTT
GATGAGGCAACCGCCAGCATTGACTCCGGTACTGAACAGGCGATTCAACATGCTCTGGCG
GCGGTGCGTGAACATACCACGCTGGTAGTGATTGCTCACCGCTTATCGACCATTGTTGAT
GCCGACACCATTCTGGTGCTTCATCGTGGGCAAGCCGTGGAGCAGGGCACTCACCAGCAA
CTGCTGGCGGCCCAGGGACGCTACTGGCAGATGTATCAACTGCAACTTGCGGGCGAAGAG
CTGGCAGCCAGCGTGCGTGAAGAGGAATCATTGAGCGCCTGA |
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Protein Properties |
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Pfam Domain Function: | |
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Protein Residues: | 593 |
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Protein Molecular Weight: | 64731 |
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Protein Theoretical pI: | 6 |
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Signaling Regions: | |
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Transmembrane Regions: | |
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Protein Sequence: | >Glyoxylate carboligase
MAKMRAVDAAMYVLEKEGITTAFGVPGAAINPFYSAMRKHGGIRHILARHVEGASHMAEG
YTRATAGNIGVCLGTSGPAGTDMITALYSASADSIPILCITGQAPRARLHKEDFQAVDIE
AIAKPVSKMAVTVREAALVPRVLQQAFHLMRSGRPGPVLVDLPFDVQVAEIEFDPDMYEP
LPVYKPAASRMQIEKAVEMLIQAERPVIVAGGGVINADAAALLQQFAELTSVPVIPTLMG
WGCIPDDHELMAGMVGLQTAHRYGNATLLASDMVFGIGNRFANRHTGSVEKYTEGRKIVH
IDIEPTQIGRVLCPDLGIVSDAKAALTLLVEVAQEMQKAGRLPCRKEWVADCQQRKRTLL
RKTHFDNVPVKPQRVYEEMNKAFGRDVCYVTTIGLSQIAAAQMLHVFKDRHWINCGQAGP
LGWTIPAALGVCAADPKRNVVAISGDFDFQFLIEELAVGAQFNIPYIHVLVNNAYLGLIR
QSQRAFDMDYCVQLAFENINSSEVNGYGVDHVKVAEGLGCKAIRVFKPEDIAPAFEQAKA
LMAQYRVPVVVEVILERVTNISMGSELDNVMEFEDIADNAADAPTETCFMHYE |
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References |
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External Links: | |
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General Reference: | - Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Chang, Y. Y., Wang, A. Y., Cronan, J. E. Jr (1993). "Molecular cloning, DNA sequencing, and biochemical analyses of Escherichia coli glyoxylate carboligase. An enzyme of the acetohydroxy acid synthase-pyruvate oxidase family." J Biol Chem 268:3911-3919. Pubmed: 8440684
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
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