Bacterioferritin (P0ABD3)

Identification
Name:Bacterioferritin
Synonyms:
  • BFR
  • Cytochrome b-1
  • Cytochrome b-557
Gene Name:bfr
Enzyme Class:
Biological Properties
General Function:Inorganic ion transport and metabolism
Specific Function:May perform analogous functions in iron detoxification and storage to that of animal ferritins
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:
  • Porphyrin and chlorophyll metabolism ec00860
KEGG Reactions:
1.0Thumb+4.0Fe2++4.0Thumb+4.0Thumb ↔ 4.0Thumb+2.0Thumb
1.0Oxygen + 4.0Fe2+ + 4.0Hydrogen ion + 4.0Fe2+ ↔ 4.0Fe3+ + 2.0Water
ReactionCard
Complex Reactions:
4.0Thumb+4.0Thumb+1.0Thumb → 4.0Thumb+2.0Thumb
4.0Iron + 4.0Hydrogen ion + 1.0Oxygen → 4.0Fe3+ + 2.0Water
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB23899Fe2+MetaboCard
ECMDB21395Fe3+MetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB00692IronMetaboCard
ECMDB04124OxygenMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
binding
catalytic activity
cation binding
ferric iron binding
ion binding
iron ion binding
metal ion binding
oxidoreductase activity
transition metal ion binding
Process
biological regulation
cation transport
cellular cation homeostasis
cellular di-, tri-valent inorganic cation homeostasis
cellular ion homeostasis
cellular iron ion homeostasis
chemical homeostasis
establishment of localization
homeostatic process
ion homeostasis
ion transport
iron ion transport
metabolic process
metal ion transport
oxidation reduction
regulation of biological quality
transition metal ion transport
transport
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>477 bp
ATGAAAGGTGATGTTAAAATCATAAATTATCTCAATAAACTATTGGGAAATGAGCTTGTC
GCAATCAATCAGTATTTTCTCCATGCCCGGATGTTTAAAAACTGGGGCCTGATGCGTCTC
AATGACGTCGAATACCATGAATCCATCGATGAGATGAAACACGCTGATAAATATATCGAG
CGTATTTTGTTTTTAGAAGGAATCCCCAACTTACAGGATTTAGGCAAACTGGGGATTGGT
GAAGATGTCGAGGAGATGCTGCAATCCGACCTGCGATTAGAACTGGAAGGCGCGAAGGAT
CTCCGTGAGGCTATCGCGTATGCCGACAGCGTTCATGACTATGTTAGCCGTGATATGATG
ATCGAGATCCTTGCCGATGAAGAAGGTCATATTGACTGGCTCGAAACTGAGCTGGATCTC
ATCGGTAAAATCGGTTTACAAAATTACCTGCAATCACAAATAAAAGTTAAAGATTAA
Protein Properties
Pfam Domain Function:
Protein Residues:158
Protein Molecular Weight:18495
Protein Theoretical pI:4
PDB File:1BFR
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Bacterioferritin
MKGDTKVINYLNKLLGNELVAINQYFLHARMFKNWGLKRLNDVEYHESIDEMKHADRYIE
RILFLEGLPNLQDLGKLNIGEDVEEMLRSDLALELDGAKNLREAIGYADSVHDYVSRDMM
IEILRDEEGHIDWLETELDLIQKMGLQNYLQAQIREEG
References
External Links:
ResourceLink
Uniprot ID:P0ABD3
Uniprot Name:BFR_ECOLI
GenBank Gene ID:AF058450
Genebank Protein ID:3065824
PDB ID:1BFR
CCDB:BFR_ECOLI
General Reference:
  • Andrews, S. C., Harrison, P. M., Guest, J. R. (1989). "Cloning, sequencing, and mapping of the bacterioferritin gene (bfr) of Escherichia coli K-12." J Bacteriol 171:3940-3947. Pubmed: 2661540
  • Andrews, S. C., Smith, J. M., Guest, J. R., Harrison, P. M. (1989). "Amino acid sequence of the bacterioferritin (cytochrome b1) of Escherichia coli-K12." Biochem Biophys Res Commun 158:489-496. Pubmed: 2644932
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Dautant, A., Meyer, J. B., Yariv, J., Precigoux, G., Sweet, R. M., Kalb, A. J., Frolow, F. (1998). "Structure of a monoclinic crystal from of cyctochrome b1 (Bacterioferritin) from E. coli." Acta Crystallogr D Biol Crystallogr 54:16-24. Pubmed: 9867433
  • Frolow, F., Kalb, A. J., Yariv, J. (1994). "Structure of a unique twofold symmetric haem-binding site." Nat Struct Biol 1:453-460. Pubmed: 7664064
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Whitchurch, C. B., Mattick, J. S. (1994). "Escherichia coli contains a set of genes homologous to those involved in protein secretion, DNA uptake and the assembly of type-4 fimbriae in other bacteria." Gene 150:9-15. Pubmed: 7959070