Record Information
Version2.0
Creation Date2012-07-30 14:55:42 -0600
Update Date2015-06-03 17:21:24 -0600
Secondary Accession Numbers
  • ECMDB21395
Identification
Name:Fe3+
DescriptionThe major activity of supplemental iron is in the prevention and treatment of iron deficiency anemia. Iron has putative immune-enhancing, anticarcinogenic and cognition-enhancing activities.
Structure
Thumb
Synonyms:
  • FE (III) ION
  • Fe(3+)
  • Fe(III)
  • Ferric ion
  • Iron(3+)
  • Iron(III) ion
  • Iron, ion (Fe(3+))
Chemical Formula:Fe
Weight:Average: 55.845
Monoisotopic: 55.934942133
InChI Key:VTLYFUHAOXGGBS-UHFFFAOYSA-N
InChI:InChI=1S/Fe/q+3
CAS number:7439-89-6
IUPAC Name:iron(3+) ion
Traditional IUPAC Name:iron(3+) ion
SMILES:[Fe+3]
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.
KingdomInorganic compounds
Super ClassHomogeneous metal compounds
ClassHomogeneous transition metal compounds
Sub ClassNot Available
Direct ParentHomogeneous transition metal compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous transition metal
Molecular FrameworkNot Available
External Descriptors
Physical Properties
State:Solid
Charge:3
Melting point:Not Available
Experimental Properties:
PropertyValueSource
Predicted Properties
PropertyValueSource
logP-0.77ChemAxon
pKa (Strongest Acidic)4.58ChemAxon
Physiological Charge3ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m³·mol⁻¹ChemAxon
Polarizability1.78 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Biological Properties
Cellular Locations:Cytoplasm
Reactions:
SMPDB Pathways:
Biosynthesis of siderophore group nonribosomal peptidesPW000760 ThumbThumb?image type=greyscaleThumb?image type=simple
Pyrimidine metabolismPW000942 ThumbThumb?image type=greyscaleThumb?image type=simple
KEGG Pathways:
  • ABC transporters ec02010
  • Biosynthesis of siderophore group nonribosomal peptides ec01053
  • Porphyrin and chlorophyll metabolism ec00860
  • Pyrimidine metabolism ec00240
EcoCyc Pathways:Not Available
Concentrations
Not Available
Spectra
Spectra:
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0a4i-9000000000-af3e7aec4f5bd9668683View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0a4i-9000000000-af3e7aec4f5bd9668683View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0a4i-9000000000-af3e7aec4f5bd9668683View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0udi-9000000000-3335fec4c3184739b75eView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0udi-9000000000-3335fec4c3184739b75eView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0udi-9000000000-3335fec4c3184739b75eView in MoNA
References
References:Not Available
Synthesis Reference:Not Available
Material Safety Data Sheet (MSDS)Not Available
External Links:
ResourceLink
CHEBI ID29034
HMDB IDHMDB12943
Pubchem Compound ID23925
Kegg IDC14819
ChemSpider ID27815
WikipediaNULL
BioCyc IDFE%2b3
EcoCyc IDFE%2b3
Ligand ExpoFE

Enzymes

General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides. Seems to reduces the complexed Fe(3+) iron of siderophores to Fe(2+), thus releasing it from the chelator
Gene Name:
fre
Uniprot ID:
P0AEN1
Molecular weight:
26242
Reactions
Reduced riboflavin + NAD(P)(+) = riboflavin + NAD(P)H.
2 cob(II)alamin + NAD(+) = 2 aquacob(III)alamin + NADH.
General function:
Involved in iron ion binding
Specific function:
Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use
Gene Name:
fes
Uniprot ID:
P13039
Molecular weight:
42569
General function:
Involved in nucleotide binding
Specific function:
Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for energy coupling to the transport system
Gene Name:
fecE
Uniprot ID:
P15031
Molecular weight:
28191
General function:
Involved in oxidoreductase activity
Specific function:
Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm
Gene Name:
cueO
Uniprot ID:
P36649
Molecular weight:
56556
General function:
Involved in transporter activity
Specific function:
Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane
Gene Name:
fecD
Uniprot ID:
P15029
Molecular weight:
34131
General function:
Involved in transporter activity
Specific function:
Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane
Gene Name:
fecC
Uniprot ID:
P15030
Molecular weight:
34892
General function:
Involved in binding
Specific function:
Binds citrate-dependent Fe(3+); part of the binding- protein-dependent transport system for uptake of citrate-dependent Fe(3+)
Gene Name:
fecB
Uniprot ID:
P15028
Molecular weight:
33146
General function:
Not Available
Specific function:
Not Available
Gene Name:
ftnA
Uniprot ID:
P0A998
Molecular weight:
Not Available
General function:
Inorganic ion transport and metabolism
Specific function:
May perform analogous functions in iron detoxification and storage to that of animal ferritins
Gene Name:
bfr
Uniprot ID:
P0ABD3
Molecular weight:
18495
Reactions
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.

Transporters

General function:
Involved in nucleotide binding
Specific function:
Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for energy coupling to the transport system
Gene Name:
fecE
Uniprot ID:
P15031
Molecular weight:
28191
General function:
Involved in transporter activity
Specific function:
Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane
Gene Name:
fecD
Uniprot ID:
P15029
Molecular weight:
34131
General function:
Involved in transporter activity
Specific function:
Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane
Gene Name:
fecC
Uniprot ID:
P15030
Molecular weight:
34892
General function:
Involved in transporter activity
Specific function:
Part of the ABC transporter complex fbpABC (TC 3.A.1.10.1) involved in Fe(3+) ions import. Probably responsible for the translocation of the substrate across the membrane
Gene Name:
fbpB
Uniprot ID:
P75681
Molecular weight:
12536
General function:
Involved in transporter activity
Specific function:
Non-specific porin
Gene Name:
ompN
Uniprot ID:
P77747
Molecular weight:
41220
General function:
Involved in transporter activity
Specific function:
Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes
Gene Name:
phoE
Uniprot ID:
P02932
Molecular weight:
38922
General function:
Involved in binding
Specific function:
Binds citrate-dependent Fe(3+); part of the binding- protein-dependent transport system for uptake of citrate-dependent Fe(3+)
Gene Name:
fecB
Uniprot ID:
P15028
Molecular weight:
33146
General function:
Involved in transporter activity
Specific function:
OmpF is a porin that forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane. It is also a receptor for the bacteriophage T2
Gene Name:
ompF
Uniprot ID:
P02931
Molecular weight:
39333
General function:
Involved in transporter activity
Specific function:
Forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane
Gene Name:
ompC
Uniprot ID:
P06996
Molecular weight:
40368