2.0 2012-07-30 14:55:42 -0600 2015-06-03 17:21:24 -0600 ECMDB21395 M2MDB001790 Fe3+ The major activity of supplemental iron is in the prevention and treatment of iron deficiency anemia. Iron has putative immune-enhancing, anticarcinogenic and cognition-enhancing activities. FE (III) ION Fe(3+) Fe(III) Ferric ion Iron(3+) Iron(III) ion Iron, ion (Fe(3+)) Fe 55.845 55.934942133 iron(3+) ion iron(3+) ion 7439-89-6 [Fe+3] InChI=1S/Fe/q+3 VTLYFUHAOXGGBS-UHFFFAOYSA-N Solid Cytosol Extra-organism Periplasm logp -0.77 ChemAxon pka_strongest_acidic 4.58 ChemAxon iupac iron(3+) ion ChemAxon average_mass 55.845 ChemAxon mono_mass 55.934942133 ChemAxon smiles [Fe+3] ChemAxon formula Fe ChemAxon inchi InChI=1S/Fe/q+3 ChemAxon inchikey VTLYFUHAOXGGBS-UHFFFAOYSA-N ChemAxon polar_surface_area 0 ChemAxon refractivity 0 ChemAxon polarizability 1.78 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 0 ChemAxon donor_count 0 ChemAxon physiological_charge 3 ChemAxon formal_charge 3 ChemAxon Pyrimidine metabolism The metabolism of pyrimidines begins with L-glutamine interacting with water molecule and a hydrogen carbonate through an ATP driven carbamoyl phosphate synthetase resulting in a hydrogen ion, an ADP, a phosphate, an L-glutamic acid and a carbamoyl phosphate. The latter compound interacts with an L-aspartic acid through a aspartate transcarbamylase resulting in a phosphate, a hydrogen ion and a N-carbamoyl-L-aspartate. The latter compound interacts with a hydrogen ion through a dihydroorotase resulting in the release of a water molecule and a 4,5-dihydroorotic acid. This compound interacts with an ubiquinone-1 through a dihydroorotate dehydrogenase, type 2 resulting in a release of an ubiquinol-1 and an orotic acid. The orotic acid then interacts with a phosphoribosyl pyrophosphate through a orotate phosphoribosyltransferase resulting in a pyrophosphate and an orotidylic acid. The latter compound then interacts with a hydrogen ion through an orotidine-5 '-phosphate decarboxylase, resulting in an release of carbon dioxide and an Uridine 5' monophosphate. The Uridine 5' monophosphate process to get phosphorylated by an ATP driven UMP kinase resulting in the release of an ADP and an Uridine 5--diphosphate. Uridine 5-diphosphate can be metabolized in multiple ways in order to produce a Deoxyuridine triphosphate. 1.-Uridine 5-diphosphate interacts with a reduced thioredoxin through a ribonucleoside diphosphate reductase 1 resulting in the release of a water molecule and an oxidized thioredoxin and an dUDP. The dUDP is then phosphorylated by an ATP through a nucleoside diphosphate kinase resulting in the release of an ADP and a DeoxyUridine triphosphate. 2.-Uridine 5-diphosphate interacts with a reduced NrdH glutaredoxin-like protein through a Ribonucleoside-diphosphate reductase 1 resulting in a release of a water molecule, an oxidized NrdH glutaredoxin-like protein and a dUDP. The dUDP is then phosphorylated by an ATP through a nucleoside diphosphate kinase resulting in the release of an ADP and a DeoxyUridine triphosphate. 3.-Uridine 5-diphosphate is phosphorylated by an ATP-driven nucleoside diphosphate kinase resulting in an ADP and an Uridinetriphosphate. The latter compound interacts with a reduced flavodoxin through ribonucleoside-triphosphate reductase resulting in the release of an oxidized flavodoxin, a water molecule and a Deoxyuridine triphosphate 4.-Uridine 5-diphosphate is phosphorylated by an ATP-driven nucleoside diphosphate kinase resulting in an ADP and an Uridinetriphosphate The uridine triphosphate interacts with a L-glutamine and a water molecule through an ATP driven CTP synthase resulting in an ADP, a phosphate, a hydrogen ion, an L-glutamic acid and a cytidine triphosphate. The cytidine triphosphate interacts with a reduced flavodoxin through a ribonucleoside-triphosphate reductase resulting in the release of a water molecule, an oxidized flavodoxin and a dCTP. The dCTP interacts with a water molecule and a hydrogen ion through a dCTP deaminase resulting in a release of an ammonium molecule and a Deoxyuridine triphosphate. 5.-Uridine 5-diphosphate is phosphorylated by an ATP-driven nucleoside diphosphate kinase resulting in an ADP and an Uridinetriphosphate The uridine triphosphate interacts with a L-glutamine and a water molecule through an ATP driven CTP synthase resulting in an ADP, a phosphate, a hydrogen ion, an L-glutamic acid and a cytidine triphosphate. The cytidine triphosphate then interacts spontaneously with a water molecule resulting in the release of a phosphate, a hydrogen ion and a CDP. The CDP then interacts with a reduced NrdH glutaredoxin-like protein through a ribonucleoside-diphosphate reductase 2 resulting in the release of a water molecule, an oxidized NrdH glutaredoxin-like protein and a dCDP. The dCDP is then phosphorylated through an ATP driven nucleoside diphosphate kinase resulting in an ADP and a dCTP. The dCTP interacts with a water molecule and a hydrogen ion through a dCTP deaminase resulting in a release of an ammonium molecule and a Deoxyuridine triphosphate. 6.-Uridine 5-diphosphate is phosphorylated by an ATP-driven nucleoside diphosphate kinase resulting in an ADP and an Uridinetriphosphate The uridine triphosphate interacts with a L-glutamine and a water molecule through an ATP driven CTP synthase resulting in an ADP, a phosphate, a hydrogen ion, an L-glutamic acid and a cytidine triphosphate. The cytidine triphosphate then interacts spontaneously with a water molecule resulting in the release of a phosphate, a hydrogen ion and a CDP. The CDP interacts with a reduced thioredoxin through a ribonucleoside diphosphate reductase 1 resulting in a release of a water molecule, an oxidized thioredoxin and a dCDP. The dCDP is then phosphorylated through an ATP driven nucleoside diphosphate kinase resulting in an ADP and a dCTP. The dCTP interacts with a water molecule and a hydrogen ion through a dCTP deaminase resulting in a release of an ammonium molecule and a Deoxyuridine triphosphate. The deoxyuridine triphosphate then interacts with a water molecule through a nucleoside triphosphate pyrophosphohydrolase resulting in a release of a hydrogen ion, a phosphate and a dUMP. The dUMP then interacts with a methenyltetrahydrofolate through a thymidylate synthase resulting in a dihydrofolic acid and a 5-thymidylic acid. Then 5-thymidylic acid is then phosphorylated through a nucleoside diphosphate kinase resulting in the release of an ADP and thymidine 5'-triphosphate. PW000942 ec00240 Metabolic Porphyrin and chlorophyll metabolism ec00860 Biosynthesis of siderophore group nonribosomal peptides 2,3-dihydroxybenzoate is synthesized from chorismate via isochorismate and 2,3-dihydroxy-2,3-dihydrobenzoate. The biosynthesis of 2,3-dihydroxybenzoate starts from chorismate being synthesized into isochorismate through isochorismate synthase entC. EntC catalyzes the conversion of chorismate to isochorismate. The N-terminal isochorismate lyase domain of EntB hydrolyzes the pyruvate group of isochorismate to produce 2,3-dihydro-2,3-dihydroxybenzoate. The conversion of this latter compound to 2,3-dihydroxybenzoate is catalyzed by the EntA dehydrogenase.This compound then interacts with L-serine and ATP through enterobactin synthase protein complex resulting in the production of enterobactin. Enterobactin is exported into the periplasmic space through the enterobactin exporter entS. The compound is the export to the environment through the outer membrane protein TolC. In the environment enterobactin reacts with iron to produce Ferric enterobactin. This compound is imported into the periplasmic space through a ferric enterobactin outermembrane transport complex. The compound then enters the cytoplasm through a ferric enterobactin ABC transporter.Once inside the cytoplasm, ferric enterobactin spontaneously releases the iron ion from the enterobactin. PW000760 ec01053 Metabolic ABC transporters ec02010 Specdb::MsMs 26960 Specdb::MsMs 26961 Specdb::MsMs 26962 Specdb::MsMs 33518 Specdb::MsMs 33519 Specdb::MsMs 33520 HMDB12943 23925 27815 C14819 29034 FE%2b3 FE NULL NAD(P)H-flavin reductase P0AEN1 FRE_ECOLI fre http://ecmdb.ca/proteins/P0AEN1.xml Enterochelin esterase P13039 FES_ECOLI fes http://ecmdb.ca/proteins/P13039.xml Fe(3+) dicitrate transport ATP-binding protein fecE P15031 FECE_ECOLI fecE http://ecmdb.ca/proteins/P15031.xml Blue copper oxidase cueO P36649 CUEO_ECOLI cueO http://ecmdb.ca/proteins/P36649.xml Fe(3+) dicitrate transport system permease protein fecD P15029 FECD_ECOLI fecD http://ecmdb.ca/proteins/P15029.xml Fe(3+) dicitrate transport system permease protein fecC P15030 FECC_ECOLI fecC http://ecmdb.ca/proteins/P15030.xml Fe(3+) dicitrate-binding periplasmic protein P15028 FECB_ECOLI fecB http://ecmdb.ca/proteins/P15028.xml ferritin iron storage protein (cytoplasmic) P0A998 ftnA http://ecmdb.ca/proteins/P0A998.xml Bacterioferritin P0ABD3 BFR_ECOLI bfr http://ecmdb.ca/proteins/P0ABD3.xml Fe(3+) dicitrate transport ATP-binding protein fecE P15031 FECE_ECOLI fecE http://ecmdb.ca/proteins/P15031.xml Fe(3+) dicitrate transport system permease protein fecD P15029 FECD_ECOLI fecD http://ecmdb.ca/proteins/P15029.xml Fe(3+) dicitrate transport system permease protein fecC P15030 FECC_ECOLI fecC http://ecmdb.ca/proteins/P15030.xml Putative ferric transport system permease protein fbpB P75681 FBPB_ECOLI fbpB http://ecmdb.ca/proteins/P75681.xml Outer membrane protein N P77747 OMPN_ECOLI ompN http://ecmdb.ca/proteins/P77747.xml Outer membrane pore protein E P02932 PHOE_ECOLI phoE http://ecmdb.ca/proteins/P02932.xml Fe(3+) dicitrate-binding periplasmic protein P15028 FECB_ECOLI fecB http://ecmdb.ca/proteins/P15028.xml Outer membrane protein F P02931 OMPF_ECOLI ompF http://ecmdb.ca/proteins/P02931.xml Outer membrane protein C P06996 OMPC_ECOLI ompC http://ecmdb.ca/proteins/P06996.xml Adenosine triphosphate + Water + Fe(III)dicitrate > ADP +2 Citric acid + Fe3+ + Hydrogen ion + Phosphate 4 Iron + 4 Hydrogen ion + Oxygen >4 Fe3+ +2 Water Ferric enterobactin + 3 Water >3 2,3-Dihydroxybenzoylserine + Fe3+ +3 Hydrogen ion FADH2 + 2 Fe3+ > FAD +2 Iron +2 Hydrogen ion coprogen unloaded (no Fe(III)) + Fe3+ > Ferric coprogen Aerobactin + Fe3+ > Aerobactin Enterochelin + Fe3+ > Ferric enterobactin Fe3+ + Fe(III)hydoxamate, unloaded > Fe(III)hydroxamate Fe3+ + Ferrichrome minus Fe(III) > Ferrichrome Fe3+ + ferroxamine minus Fe(3) > Ferroxamine 2 [4Fe-4S] iron-sulfur cluster + 2 Hydrogen ion + Hydrogen peroxide >2 [3Fe-4S] damaged iron-sulfur cluster +2 Fe3+ +2 Water 2 [4Fe-4S] iron-sulfur cluster + 2 Hydrogen ion + 2 Nitric oxide >2 [3Fe-4S] damaged iron-sulfur cluster +2 Fe3+ + Water + Nitrous oxide Oxygen + 4 Fe2+ + 4 Hydrogen ion + 4 Fe2+ <>4 Fe3+ +2 Water R00078 2 Iron + Hydrogen peroxide + 2 Hydrogen ion >2 Fe3+ +2 Water ADP + Phosphate + 4 Hydrogen ion + Heme + Nickel(2+) + Iron chelate + Taurine + Molybdate + Magnesium + Fe3+ + Potassium + Polyamine + vitamin B12 + Sulfate + glycerol-3-phosphate + Phosphonate + D-Maltose <> Adenosine triphosphate +3 Hydrogen ion + Water R00086 RXN0-1061 Oxygen + 4 Fe2+ + 4 Hydrogen ion <>4 Fe3+ +2 Water Oxygen + 4 Fe2+ + 4 Hydrogen ion <>4 Fe3+ +2 Water