Fe3+ (ECMDB21395) (M2MDB001790)
Record Information | |||||||||||||||||||||||||||||||||||||||||||||||||
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Version | 2.0 | ||||||||||||||||||||||||||||||||||||||||||||||||
Creation Date | 2012-07-30 14:55:42 -0600 | ||||||||||||||||||||||||||||||||||||||||||||||||
Update Date | 2015-06-03 17:21:24 -0600 | ||||||||||||||||||||||||||||||||||||||||||||||||
Secondary Accession Numbers |
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Identification | |||||||||||||||||||||||||||||||||||||||||||||||||
Name: | Fe3+ | ||||||||||||||||||||||||||||||||||||||||||||||||
Description | The major activity of supplemental iron is in the prevention and treatment of iron deficiency anemia. Iron has putative immune-enhancing, anticarcinogenic and cognition-enhancing activities. | ||||||||||||||||||||||||||||||||||||||||||||||||
Structure | |||||||||||||||||||||||||||||||||||||||||||||||||
Synonyms: |
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Chemical Formula: | Fe | ||||||||||||||||||||||||||||||||||||||||||||||||
Weight: | Average: 55.845 Monoisotopic: 55.934942133 | ||||||||||||||||||||||||||||||||||||||||||||||||
InChI Key: | VTLYFUHAOXGGBS-UHFFFAOYSA-N | ||||||||||||||||||||||||||||||||||||||||||||||||
InChI: | InChI=1S/Fe/q+3 | ||||||||||||||||||||||||||||||||||||||||||||||||
CAS number: | 7439-89-6 | ||||||||||||||||||||||||||||||||||||||||||||||||
IUPAC Name: | iron(3+) ion | ||||||||||||||||||||||||||||||||||||||||||||||||
Traditional IUPAC Name: | iron(3+) ion | ||||||||||||||||||||||||||||||||||||||||||||||||
SMILES: | [Fe+3] | ||||||||||||||||||||||||||||||||||||||||||||||||
Chemical Taxonomy | |||||||||||||||||||||||||||||||||||||||||||||||||
Description | belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom. | ||||||||||||||||||||||||||||||||||||||||||||||||
Kingdom | Inorganic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||
Super Class | Homogeneous metal compounds | ||||||||||||||||||||||||||||||||||||||||||||||||
Class | Homogeneous transition metal compounds | ||||||||||||||||||||||||||||||||||||||||||||||||
Sub Class | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
Direct Parent | Homogeneous transition metal compounds | ||||||||||||||||||||||||||||||||||||||||||||||||
Alternative Parents | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
Substituents |
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Molecular Framework | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
External Descriptors |
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Physical Properties | |||||||||||||||||||||||||||||||||||||||||||||||||
State: | Solid | ||||||||||||||||||||||||||||||||||||||||||||||||
Charge: | 3 | ||||||||||||||||||||||||||||||||||||||||||||||||
Melting point: | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
Experimental Properties: |
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Predicted Properties |
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Biological Properties | |||||||||||||||||||||||||||||||||||||||||||||||||
Cellular Locations: | Cytoplasm | ||||||||||||||||||||||||||||||||||||||||||||||||
Reactions: | ADP + Phosphate + 4 Hydrogen ion + Heme + Nickel(2+) + Iron chelate + Taurine + Molybdate + Magnesium + Fe3+ + Potassium + Polyamine + vitamin B12 + Sulfate + glycerol-3-phosphate + Phosphonate + D-Maltose <> Adenosine triphosphate +3 Hydrogen ion + Water Adenosine triphosphate + Water + Fe(III)dicitrate > ADP +2 Citric acid + Fe3+ + Hydrogen ion + Phosphate 4 Iron + 4 Hydrogen ion + Oxygen >4 Fe3+ +2 Water Ferric enterobactin + 3 Water >3 2,3-Dihydroxybenzoylserine + Fe3+ +3 Hydrogen ion FADH2 + 2 Fe3+ > FAD +2 Iron +2 Hydrogen ion coprogen unloaded (no Fe(III)) + Fe3+ > Ferric coprogen Aerobactin + Fe3+ > Aerobactin Enterochelin + Fe3+ > Ferric enterobactin Fe3+ + Fe(III)hydoxamate, unloaded > Fe(III)hydroxamate Fe3+ + Ferrichrome minus Fe(III) > Ferrichrome Fe3+ + ferroxamine minus Fe(3) > Ferroxamine 2 [4Fe-4S] iron-sulfur cluster + 2 Hydrogen ion + Hydrogen peroxide >2 [3Fe-4S] damaged iron-sulfur cluster +2 Fe3+ +2 Water 2 [4Fe-4S] iron-sulfur cluster + 2 Hydrogen ion + 2 Nitric oxide >2 [3Fe-4S] damaged iron-sulfur cluster +2 Fe3+ + Water + Nitrous oxide Oxygen + 4 Fe2+ + 4 Hydrogen ion + 4 Fe2+ <>4 Fe3+ +2 Water 2 Iron + Hydrogen peroxide + 2 Hydrogen ion >2 Fe3+ +2 Water Oxygen + 4 Fe2+ + 4 Hydrogen ion <>4 Fe3+ +2 Water Oxygen + 4 Fe2+ + 4 Hydrogen ion <>4 Fe3+ +2 Water | ||||||||||||||||||||||||||||||||||||||||||||||||
SMPDB Pathways: |
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KEGG Pathways: | |||||||||||||||||||||||||||||||||||||||||||||||||
EcoCyc Pathways: | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
Concentrations | |||||||||||||||||||||||||||||||||||||||||||||||||
Not Available | |||||||||||||||||||||||||||||||||||||||||||||||||
Spectra | |||||||||||||||||||||||||||||||||||||||||||||||||
Spectra: |
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References | |||||||||||||||||||||||||||||||||||||||||||||||||
References: | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
Synthesis Reference: | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
Material Safety Data Sheet (MSDS) | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||
Links | |||||||||||||||||||||||||||||||||||||||||||||||||
External Links: |
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Enzymes
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides. Seems to reduces the complexed Fe(3+) iron of siderophores to Fe(2+), thus releasing it from the chelator
- Gene Name:
- fre
- Uniprot ID:
- P0AEN1
- Molecular weight:
- 26242
Reactions
Reduced riboflavin + NAD(P)(+) = riboflavin + NAD(P)H. |
2 cob(II)alamin + NAD(+) = 2 aquacob(III)alamin + NADH. |
- General function:
- Involved in iron ion binding
- Specific function:
- Upon internalization, ferric enterobactin is processed via an exquisitely specific pathway that is dependent on FES activity, making iron available for metabolic use
- Gene Name:
- fes
- Uniprot ID:
- P13039
- Molecular weight:
- 42569
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for energy coupling to the transport system
- Gene Name:
- fecE
- Uniprot ID:
- P15031
- Molecular weight:
- 28191
- General function:
- Involved in oxidoreductase activity
- Specific function:
- Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm
- Gene Name:
- cueO
- Uniprot ID:
- P36649
- Molecular weight:
- 56556
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- fecD
- Uniprot ID:
- P15029
- Molecular weight:
- 34131
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- fecC
- Uniprot ID:
- P15030
- Molecular weight:
- 34892
- General function:
- Involved in binding
- Specific function:
- Binds citrate-dependent Fe(3+); part of the binding- protein-dependent transport system for uptake of citrate-dependent Fe(3+)
- Gene Name:
- fecB
- Uniprot ID:
- P15028
- Molecular weight:
- 33146
- General function:
- Not Available
- Specific function:
- Not Available
- Gene Name:
- ftnA
- Uniprot ID:
- P0A998
- Molecular weight:
- Not Available
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- May perform analogous functions in iron detoxification and storage to that of animal ferritins
- Gene Name:
- bfr
- Uniprot ID:
- P0ABD3
- Molecular weight:
- 18495
Reactions
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O. |
Transporters
- General function:
- Involved in nucleotide binding
- Specific function:
- Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for energy coupling to the transport system
- Gene Name:
- fecE
- Uniprot ID:
- P15031
- Molecular weight:
- 28191
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- fecD
- Uniprot ID:
- P15029
- Molecular weight:
- 34131
- General function:
- Involved in transporter activity
- Specific function:
- Part of the binding-protein-dependent transport system for citrate-dependent Fe(3+). Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- fecC
- Uniprot ID:
- P15030
- Molecular weight:
- 34892
- General function:
- Involved in transporter activity
- Specific function:
- Part of the ABC transporter complex fbpABC (TC 3.A.1.10.1) involved in Fe(3+) ions import. Probably responsible for the translocation of the substrate across the membrane
- Gene Name:
- fbpB
- Uniprot ID:
- P75681
- Molecular weight:
- 12536
- General function:
- Involved in transporter activity
- Specific function:
- Non-specific porin
- Gene Name:
- ompN
- Uniprot ID:
- P77747
- Molecular weight:
- 41220
- General function:
- Involved in transporter activity
- Specific function:
- Uptake of inorganic phosphate, phosphorylated compounds, and some other negatively charged solutes
- Gene Name:
- phoE
- Uniprot ID:
- P02932
- Molecular weight:
- 38922
- General function:
- Involved in binding
- Specific function:
- Binds citrate-dependent Fe(3+); part of the binding- protein-dependent transport system for uptake of citrate-dependent Fe(3+)
- Gene Name:
- fecB
- Uniprot ID:
- P15028
- Molecular weight:
- 33146
- General function:
- Involved in transporter activity
- Specific function:
- OmpF is a porin that forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane. It is also a receptor for the bacteriophage T2
- Gene Name:
- ompF
- Uniprot ID:
- P02931
- Molecular weight:
- 39333
- General function:
- Involved in transporter activity
- Specific function:
- Forms passive diffusion pores which allow small molecular weight hydrophilic materials across the outer membrane
- Gene Name:
- ompC
- Uniprot ID:
- P06996
- Molecular weight:
- 40368