D-serine/D-alanine/glycine transporter (P0AAE1)

Identification
Name:D-serine/D-alanine/glycine transporter
Synonyms:Not Available
Gene Name:cycA
Enzyme Class:Not Available
Biological Properties
General Function:Involved in transport
Specific Function:Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:
KEGG Pathways:
Transports:
Transport References:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Component
cell part
integral to membrane
intrinsic to membrane
membrane
membrane part
Function
active transmembrane transporter activity
amine transmembrane transporter activity
amino acid transmembrane transporter activity
transmembrane transporter activity
transporter activity
Process
amine transport
amino acid transport
establishment of localization
transmembrane transport
transport
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>1413 bp
ATGACTCATAAAGGAGATACCCCGATGACCATTACTCCGGCAACTCATGCAATTTCGATA
AATCCTGCCACGGGTGAACAACTTTCTGTGTTGCCGTGGGCTGGCGCTGATGATATCGAA
AACGCACTTCAGCTGGCGGCAGCAGGCTTTCGTGACTGGCGCGAGACAAATATAGATTAT
CGTGCTGAAAAACTGCGTGATATCGGTAAGGCTCTGCGCGCCCGTAGCGAAGAAATGGCG
CAAATGATCACCCGCGAAATGGGCAAACCAATCAACCAGGCGCGCGCTGAAGTGGCGAAA
TCGGCGAATTTGTGTGACTGGTATGCAGAACATGGTCCGGCAATGCTGAAGGCGGAACCT
ACGCTGGTGGAAAATCAGCAGGCAGTTATTGAGTATCGACCGTTGGGGACGATTCTGGCG
ATTATGCCGTGGAATTTTCCGTTATGGCAGGTGATGCGTGGCGCTGTTCCCATCATTCTT
GCTGGTAACGGATACTTACTTAAACATGCGCCGAATGTGATGGGCTGTGCTCAGCTCATT
GCCCAGGTGTTTAAAGATGCGGGAATCCCACAAGGCGTATATGGCTGGCTGAATGCCGAC
AATGACGGTGTCACTCAGATGATTAAAGACTCGCGCATTGCTGCTATCACGGTGACCGGA
AGTGTTCGTGCTGGAGCGGCTATTGGTGCACAGGCTGGAGCGGCACTGAAAAAATGCGTA
CTGGAACTGGGCGGTTCGGATCCATTTATTGTGCTTAACGATGCCGATCTGGAACTGGCA
GTTAAAGCGGCGGTAGCCGGACGTTATCAGAATACCGGACAGGTTTGTGCAGCGGCAAAA
CGCTTTATTATCGAAGAGGGAATTGCTTCGGCATTTACCGAACGTTTTGTGGCAGCTGCG
GCAGCCTTGAAAATGGACGATCCCCGTGACGAAGAGAACGCTCTCGGACCAATGGCTCGT
TTCGATTTACGTGATGAGCTGCATCATCAGGTGGAGAAAACCCTGGCGCAGGGTGCGCGT
TTGTTACTGGGCGGGGAAAAGATGGCTGGGGCAGGTAACTACTATCCGCCAACGGTTCTG
GCGAATGTTACCCCAGAAATGACCGCTTTTCGGGAAGAAATGTTTGGCCCCGTTGCGGCA
ATCACCATTGCGAAAGATGCAGAACATGCGCTGGAACTGGCTAATGATAGTGAGTTCGGC
CTTTCAGCGACCATTTTTACCACCGACGAAACACAGGCCAGACAGATGGCGGCACGTCTG
GAATGCGGTGGGGTGTTTATCAATGGTTATTGTGCCAGCGACGCGCGAGTGGCCTTTGGT
GGCGTGAAAAAGAGTGGCTTTGGTCGTGAGCTTTCCCATTTCGGCTTACACGAATTCTGT
AATATCCAGACGGTGTGGAAAGACCGGATCTGA
Protein Properties
Pfam Domain Function:
Protein Residues:470
Protein Molecular Weight:51659
Protein Theoretical pI:9
Signaling Regions:
  • None
Transmembrane Regions:
  • 30-50
  • 51-71
  • 102-122
  • 137-157
  • 162-182
  • 211-231
  • 256-276
  • 283-303
  • 350-370
  • 371-391
  • 413-433
  • 441-461
Protein Sequence:
>D-serine/D-alanine/glycine transporter
MVDQVKVVADDQAPAEQSLRRNLTNRHIQLIAIGGAIGTGLFMGSGKTISLAGPSIIFVY
MIIGFMLFFVMRAMGELLLSNLEYKSFSDFASDLLGPWAGYFTGWTYWFCWVVTGMADVV
AITAYAQFWFPDLSDWVASLAVIVLLLTLNLATVKMFGEMEFWFAMIKIVAIVSLIVVGL
VMVAMHFQSPTGVEASFAHLWNDGGWFPKGLSGFFAGFQIAVFAFVGIELVGTTAAETKD
PEKSLPRAINSIPIRIIMFYVFALIVIMSVTPWSSVVPEKSPFVELFVLVGLPAAASVIN
FVVLTSAASSANSGVFSTSRMLFGLAQEGVAPKAFAKLSKRAVPAKGLTFSCICLLGGVV
MLYVNPSVIGAFTMITTVSAILFMFVWTIILCSYLVYRKQRPHLHEKSIYKMPLGKLMCW
VCMAFFVFVVVLLTLEDDTRQALLVTPLWFIALGLGWLFIGKKRAAELRK
References
External Links:
ResourceLink
Uniprot ID:P0AAE1
Uniprot Name:CYCA_ECO57
GenBank Gene ID:AE005174
Genebank Protein ID:12515137
EchoBASE ID:EB2397
CCDB:CYCA_ECO57
General Reference:
  • Hayashi, T., Makino, K., Ohnishi, M., Kurokawa, K., Ishii, K., Yokoyama, K., Han, C. G., Ohtsubo, E., Nakayama, K., Murata, T., Tanaka, M., Tobe, T., Iida, T., Takami, H., Honda, T., Sasakawa, C., Ogasawara, N., Yasunaga, T., Kuhara, S., Shiba, T., Hattori, M., Shinagawa, H. (2001). "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12." DNA Res 8:11-22. Pubmed: 11258796
  • Perna, N. T., Plunkett, G. 3rd, Burland, V., Mau, B., Glasner, J. D., Rose, D. J., Mayhew, G. F., Evans, P. S., Gregor, J., Kirkpatrick, H. A., Posfai, G., Hackett, J., Klink, S., Boutin, A., Shao, Y., Miller, L., Grotbeck, E. J., Davis, N. W., Lim, A., Dimalanta, E. T., Potamousis, K. D., Apodaca, J., Anantharaman, T. S., Lin, J., Yen, G., Schwartz, D. C., Welch, R. A., Blattner, F. R. (2001). "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7." Nature 409:529-533. Pubmed: 11206551