Glycine (ECMDB00123) (M2MDB000046)

General function:

Involved in nucleotide binding

Specific function:

ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)

Gene Name:

glyQ

Uniprot ID:

P00960

Molecular weight:

34774

Reactions

General function:

Involved in arginine-tRNA ligase activity

Specific function:

ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)

Gene Name:

glyS

Uniprot ID:

P00961

Molecular weight:

76812

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione

Gene Name:

gshB

Uniprot ID:

P04425

Molecular weight:

35561

Reactions

General function:

Involved in proteolysis

Specific function:

Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation

Gene Name:

pepN

Uniprot ID:

P04825

Molecular weight:

98918

Reactions

General function:

Involved in catalytic activity

Specific function:

Interconversion of serine and glycine

Gene Name:

glyA

Uniprot ID:

P0A825

Molecular weight:

45316

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes

Gene Name:

lpdA

Uniprot ID:

P0A9P0

Molecular weight:

50688

Reactions

General function:

Involved in glycine C-acetyltransferase activity

Specific function:

Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA

Gene Name:

kbl

Uniprot ID:

P0AB77

Molecular weight:

43117

Reactions

General function:

Involved in hydrolase activity

Specific function:

Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipeptide amides and formyl amino acids are hydrolyzed. Also shows cysteinylglycinase activity, which is sufficient for E.coli to utilize cysteinylglycine as a cysteine source

Gene Name:

pepD

Uniprot ID:

P15288

Molecular weight:

52915

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide

Gene Name:

purD

Uniprot ID:

P15640

Molecular weight:

45940

Reactions

General function:

Involved in aminomethyltransferase activity

Specific function:

The glycine cleavage system catalyzes the degradation of glycine

Gene Name:

gcvT

Uniprot ID:

P27248

Molecular weight:

40146

Reactions

General function:

Involved in glycine dehydrogenase (decarboxylating) activity

Specific function:

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein

Gene Name:

gcvP

Uniprot ID:

P33195

Molecular weight:

104376

Reactions

General function:

Involved in aminopeptidase activity

Specific function:

Probably plays an important role in intracellular peptide degradation

Gene Name:

pepB

Uniprot ID:

P37095

Molecular weight:

46180

Reactions

General function:

Involved in aminopeptidase activity

Specific function:

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Required for plasmid ColE1 site-specific recombination but not in its aminopeptidase activity. Could act as a structural component of the putative nucleoprotein complex in which the Xer recombination reaction takes place

Gene Name:

pepA

Uniprot ID:

P68767

Molecular weight:

54879

Reactions

General function:

Involved in lyase activity

Specific function:

Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates

Gene Name:

ltaE

Uniprot ID:

P75823

Molecular weight:

36494

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the oxidative demethylation of N-methyl-L- tryptophan. Can also use other N-methyl amino acids, including sarcosine, which, however, is a poor substrate

Gene Name:

solA

Uniprot ID:

P40874

Molecular weight:

40902

Reactions

General function:

Amino acid transport and metabolism

Specific function:

The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein

Gene Name:

gcvH

Uniprot ID:

P0A6T9

Molecular weight:

13811