L-Alanine (ECMDB00161) (M2MDB000063)

General function:

Involved in nucleotide binding

Specific function:

Edits incorrectly charged Ser-tRNA(Ala) and Gly- tRNA(Ala) but not incorrectly charged Ser-tRNA(Thr)

Gene Name:

alaS

Uniprot ID:

P00957

Molecular weight:

96032

Reactions

General function:

Involved in transferase activity

Specific function:

L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine

Gene Name:

avtA

Uniprot ID:

P09053

Molecular weight:

46711

Reactions

General function:

Involved in alanine racemase activity

Specific function:

Provides the D-alanine required for cell wall biosynthesis

Gene Name:

alr

Uniprot ID:

P0A6B4

Molecular weight:

39153

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for NAD, biotin and Fe-S cluster synthesis. Transfers sulfur on 'Cys-456' of thiI in a transpersulfidation reaction. Transfers sulfur on 'Cys-19' of tusA in a transpersulfidation reaction. Functions also as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate

Gene Name:

iscS

Uniprot ID:

P0A6B7

Molecular weight:

45089

Reactions

General function:

Involved in catalytic activity

Specific function:

Interconversion of serine and glycine

Gene Name:

glyA

Uniprot ID:

P0A825

Molecular weight:

45316

Reactions

General function:

Involved in 8-amino-7-oxononanoate synthase activity

Specific function:

Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide

Gene Name:

bioF

Uniprot ID:

P12998

Molecular weight:

41594

Reactions

General function:

Involved in hydrolase activity

Specific function:

Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipeptide amides and formyl amino acids are hydrolyzed. Also shows cysteinylglycinase activity, which is sufficient for E.coli to utilize cysteinylglycine as a cysteine source

Gene Name:

pepD

Uniprot ID:

P15288

Molecular weight:

52915

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

murC

Uniprot ID:

P17952

Molecular weight:

53626

Reactions

General function:

Involved in N-acetylmuramoyl-L-alanine amidase activity

Specific function:

Cell-wall hydrolase probably involved in cell-wall hydrolysis, septation or recycling

Gene Name:

amiB

Uniprot ID:

P26365

Molecular weight:

47985

Reactions

General function:

Involved in alanine racemase activity

Specific function:

Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by dadA

Gene Name:

dadX

Uniprot ID:

P29012

Molecular weight:

38844

Reactions

General function:

Involved in N-acetylmuramoyl-L-alanine amidase activity

Specific function:

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides

Gene Name:

amiA

Uniprot ID:

P36548

Molecular weight:

31412

Reactions

General function:

Involved in N-acetylmuramoyl-L-alanine amidase activity

Specific function:

Cell-wall hydrolase probably involved in cell-wall hydrolysis, septation or recycling

Gene Name:

amiC

Uniprot ID:

P63883

Molecular weight:

45634

Reactions

General function:

Involved in lyase activity

Specific function:

Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates

Gene Name:

ltaE

Uniprot ID:

P75823

Molecular weight:

36494

Reactions

General function:

Defense mechanisms

Specific function:

Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso- Dap-D-Ala. To a lesser extent, can also cleave D-Ala from murein derivatives containing the tetrapeptide, i.e. MurNAc-tetrapeptide, UDP-MurNAc-tetrapeptide, GlcNAc-MurNAc-tetrapeptide, and GlcNAc- anhMurNAc-tetrapeptide. Does not act on murein sacculi or cross- linked muropeptides. The tripeptides produced by the lcdA reaction can then be reused as peptidoglycan building blocks; lcdA is thereby involved in murein recycling. Is also essential for viability during stationary phase

Gene Name:

ldcA

Uniprot ID:

P76008

Molecular weight:

33567

Reactions

General function:

Involved in metabolic process

Specific function:

Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo

Gene Name:

sufS

Uniprot ID:

P77444

Molecular weight:

44433

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine. L-cysteine sulfinic acid is the best substrate. Functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate

Gene Name:

csdA

Uniprot ID:

Q46925

Molecular weight:

43234

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane

Gene Name:

livH

Uniprot ID:

P0AEX7

Molecular weight:

32982

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane

Gene Name:

livM

Uniprot ID:

P22729

Molecular weight:

46269

General function:

Involved in 1-aminocyclopropane-1-carboxylate synthase activity

Specific function:

Specific function unknown

Gene Name:

yfbQ

Uniprot ID:

P0A959

Molecular weight:

45517

Reactions

General function:

Not Available

Specific function:

Participates in cysteine desulfuration mediated by sufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for sufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of sufS, an intermediate product of cysteine desulfuration process. Together with the sufBCD complex, it thereby enhances up to 50- fold, the cysteine desulfurase activity of sufS. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Does not affect the selenocysteine lyase activity of sufS

Gene Name:

sufE

Uniprot ID:

P76194

Molecular weight:

15800

General function:

Involved in nucleotide binding

Specific function:

Component of the leucine-specific transport system

Gene Name:

livG

Uniprot ID:

P0A9S7

Molecular weight:

28427

General function:

Involved in amino acid transport

Specific function:

This protein is a component of the leucine, isoleucine, valine, (threonine) transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids

Gene Name:

livJ

Uniprot ID:

P0AD96

Molecular weight:

39076

General function:

Involved in nucleotide binding

Specific function:

Component of the leucine-specific transport system

Gene Name:

livF

Uniprot ID:

P22731

Molecular weight:

26310

General function:

Amino acid transport and metabolism

Specific function:

Specific function unknown

Gene Name:

yfdZ

Uniprot ID:

P77434

Molecular weight:

46216

Reactions