Galactitol-1-phosphate 5-dehydrogenase (P0A9S3)

Identification
Name:Galactitol-1-phosphate 5-dehydrogenase
Synonyms:Not Available
Gene Name:gatD
Enzyme Class:
Biological Properties
General Function:Involved in zinc ion binding
Specific Function:Converts galactitol 1-phosphate to tagatose 6-phosphate
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb+1.0Thumb
1.0Galactitol 1-phosphate + 1.0NAD ↔ 1.0Hydrogen ion + 1.0NADH + 1.0D-Tagatose 6-phosphate
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb+1.0Thumb
1.0NAD + 1.0Galactitol 1-phosphate ↔ 1.0L-Tagatose-6-phosphate + 1.0NADH + 1.0Hydrogen ion
ReactionCard
SMPDB Reactions:
1.0Galactose 1-phosphate+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb
1.0Galactose 1-phosphate + 1.0NAD + 1.0Galactose 1-phosphate → 1.0NADH + 1.0Hydrogen ion + 1.0D-tagatofuranose 6-phosphate
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb+1.0Thumb
1.0Galactitol 1-phosphate + 1.0NAD ↔ 1.0Hydrogen ion + 1.0NADH + 1.0D-Tagatose 6-phosphate
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0Galactitol 1-phosphate + 1.0NAD → 1.0L-Tagatose-6-phosphate + 1.0NADH
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB24205D-tagatofuranose 6-phosphateMetaboCard
ECMDB06873D-Tagatose 6-phosphateMetaboCard
ECMDB20149Galactitol 1-phosphateMetaboCard
ECMDB04011Galactose 1-phosphateMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB23065L-Tagatose-6-phosphateMetaboCard
ECMDB00902NADMetaboCard
ECMDB01487NADHMetaboCard
GO Classification:
Function
binding
catalytic activity
cation binding
ion binding
metal ion binding
oxidoreductase activity
transition metal ion binding
zinc ion binding
Process
metabolic process
oxidation reduction
Gene Properties
Blattner:b2091
Gene OrientationCounterclockwise
Centisome Percentage:46.77
Left Sequence End2169857
Right Sequence End2170897
Gene Sequence:
>1041 bp
ATGGCTCACCGCCCACGCTGGACATTGTCGCAAGTCACAGAATTATTTGAAAAACCGTTG
CTGGATCTGCTGTTTGAAGCGCAGCAGGTGCATCGCCAGCATTTCGATCCTCGTCAGGTG
CAGGTCAGCACGTTGCTGTCGATTAAGACCGGAGCTTGTCCGGAAGATTGCAAATACTGC
CCGCAAAGCTCGCGCTACAAAACCGGGCTGGAAGCCGAGCGGTTGATGGAAGTTGAACAG
GTGCTGGAGTCGGCGCGCAAAGCGAAAGCGGCAGGATCGACGCGCTTCTGTATGGGCGCG
GCGTGGAAGAATCCCCACGAACGCGATATGCCGTACCTGGAACAAATGGTGCAGGGGGTA
AAAGCGATGGGGCTGGAGGCGTGTATGACGCTGGGCACGTTGAGTGAATCTCAGGCGCAG
CGCCTCGCGAACGCCGGGCTGGATTACTACAACCACAACCTGGACACCTCGCCGGAGTTT
TACGGCAATATCATCACCACACGCACTTATCAGGAACGCCTCGATACGCTGGAAAAAGTG
CGCGATGCCGGGATCAAAGTCTGTTCTGGCGGCATTGTGGGCTTAGGCGAAACGGTAAAA
GATCGCGCCGGATTATTGCTGCAACTGGCAAACCTGCCGACGCCGCCGGAAAGCGTGCCA
ATCAACATGCTGGTGAAGGTGAAAGGCACGCCGCTTGCCGATAACGATGATGTCGATGCC
TTTGATTTTATTCGCACCATTGCGGTCGCGCGGATCATGATGCCAACCTCTTACGTGCGC
CTTTCTGCCGGACGCGAGCAGATGAACGAACAGACTCAGGCGATGTGCTTTATGGCAGGC
GCAAACTCGATTTTCTACGGTTGCAAACTGCTGACCACGCCGAATCCGGAAGAAGATAAA
GACCTGCAACTGTTCCGCAAACTGGGGCTAAATCCGCAGCAAACTGCCGTGCTGGCAGGG
GATAACGAACAACAGCAACGTCTTGAACAGGCGCTGATGACCCCGGACACCGACGAATAT
TACAACGCGGCAGCATTATGA
Protein Properties
Pfam Domain Function:
Protein Residues:346
Protein Molecular Weight:37390
Protein Theoretical pI:6
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Galactitol-1-phosphate 5-dehydrogenase
MKSVVNDTDGIVRVAESVIPEIKHQDEVRVKIASSGLCGSDLPRIFKNGAHYYPITLGHE
FSGYIDAVGSGVDDLHPGDAVACVPLLPCFTCPECLKGFYSQCAKYDFIGSRRDGGFAEY
IVVKRKNVFALPTDMPIEDGAFIEPITVGLHAFHLAQGCENKNVIIIGAGTIGLLAIQCA
VALGAKSVTAIDISSEKLALAKSFGAMQTFNSSEMSAPQMQSVLRELRFNQLILETAGVP
QTVELAVEIAGPHAQLALVGTLHQDLHLTSATFGKILRKELTVIGSWMNYSSPWPGQEWE
TASRLLTERKLSLEPLIAHRGSFESFAQAVRDIARNAMPGKVLLIP
References
External Links:
ResourceLink
Uniprot ID:P0A9S3
Uniprot Name:GATD_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674758
Ecogene ID:EG12417
Ecocyc:EG12417
ColiBase:b2091
Kegg Gene:b2091
EchoBASE ID:EB2316
CCDB:GATD_ECOLI
BacMap:16130029
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Itoh, T., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Kasai, H., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Seki, Y., Horiuchi, T., et, a. l. .. (1996). "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." DNA Res 3:379-392. Pubmed: 9097040
  • Nobelmann, B., Lengeler, J. W. (1995). "Sequence of the gat operon for galactitol utilization from a wild-type strain EC3132 of Escherichia coli." Biochim Biophys Acta 1262:69-72. Pubmed: 7772602