Fumarate reductase subunit D (P0A8Q3)

Identification
Name:Fumarate reductase subunit D
Synonyms:
  • Fumarate reductase 13 kDa hydrophobic protein
Gene Name:frdD
Enzyme Class:Not Available
Biological Properties
General Function:Involved in fumarate metabolic process
Specific Function:Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Succinic acid + 1.0FAD ↔ 1.0FADH2 + 1.0Fumaric acid
ReactionCard
1.0Thumb+1.0Acceptor ↔ 1.0Thumb+1.0Reduced acceptor
1.0Succinic acid + 1.0Acceptor ↔ 1.0Fumaric acid + 1.0Reduced acceptor
ReactionCard
SMPDB Reactions:
1.0Thumb+2.0Thumb+1.0a menaquinol → 1.0Thumb+1.0a menaquinone
1.0Fumaric acid + 2.0Hydrogen ion + 1.0a menaquinol → 1.0Succinic acid + 1.0a menaquinone
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb → 1.0Menaquinone 8+1.0Thumb
1.0Fumaric acid + 1.0Menaquinol 8 → 1.0Menaquinone 8 + 1.0Succinic acid
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.02-Demethylmenaquinol 8 + 1.0Fumaric acid → 1.02-Demethylmenaquinone 8 + 1.0Succinic acid
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB211542-Demethylmenaquinol 8MetaboCard
ECMDB211552-Demethylmenaquinone 8MetaboCard
ECMDB01248FADMetaboCard
ECMDB01197FADH2MetaboCard
ECMDB00176Fumaric acidMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB02434HydroquinoneMetaboCard
ECMDB21245Menaquinol 8MetaboCard
ECMDB23060QuinoneMetaboCard
ECMDB00254Succinic acidMetaboCard
GO Classification:
Component
cell part
membrane
Process
carboxylic acid metabolic process
cellular metabolic process
dicarboxylic acid metabolic process
fumarate metabolic process
metabolic process
organic acid metabolic process
oxoacid metabolic process
Gene Properties
Blattner:b4151
Gene OrientationCounterclockwise
Centisome Percentage:94.34
Left Sequence End4377030
Right Sequence End4377389
Gene Sequence:
>360 bp
GTGGCAGAAGAAACTATATTCAGCAAAATTATTCGTCGTGAGATCCCCTCCGATATCGTC
TACCAGGATGATCTGGTAACGGCGTTTCGCGATATTTCGCCGCAAGCGCCAACGCATATT
CTGATCATTCCGAATATCCTCATTCCGACTGTGAACGACGTCTCAGCTGAGCATGAGCAG
GCGCTGGGACGCATGATCACCGTAGCGGCAAAAATTGCTGAGCAAGAAGGTATTGCCGAA
GATGGCTATCGTCTGATCATGAATACCAACCGCCATGGCGGACAAGAGGTTTACCACATC
CATATGCACTTGTTGGGTGGCCGTCCGCTGGGACCAATGCTGGCGCATAAAGGTCTGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:119
Protein Molecular Weight:13107
Protein Theoretical pI:9
PDB File:1L0V
Signaling Regions:
  • None
Transmembrane Regions:
  • 9-35
  • 61-89
  • 97-115
Protein Sequence:
>Fumarate reductase subunit D
MINPNPKRSDEPVFWGLFGAGGMWSAIIAPVMILLVGILLPLGLFPGDALSYERVLAFAQ
SFIGRVFLFLMIVLPLWCGLHRMHHAMHDLKIHVPAGKWVFYGLAAILTVVTLIGVVTI
References
External Links:
ResourceLink
Uniprot ID:P0A8Q3
Uniprot Name:FRDD_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:4062667
PDB ID:1L0V
Ecogene ID:EG10333
Ecocyc:EG10333
ColiBase:b4151
Kegg Gene:b4151
EchoBASE ID:EB0329
CCDB:FRDD_ECOLI
BacMap:16131976
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Burland, V., Plunkett, G. 3rd, Sofia, H. J., Daniels, D. L., Blattner, F. R. (1995). "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Nucleic Acids Res 23:2105-2119. Pubmed: 7610040
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Grundstrom, T., Jaurin, B. (1982). "Overlap between ampC and frd operons on the Escherichia coli chromosome." Proc Natl Acad Sci U S A 79:1111-1115. Pubmed: 7041115
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Iverson, T. M., Luna-Chavez, C., Cecchini, G., Rees, D. C. (1999). "Structure of the Escherichia coli fumarate reductase respiratory complex." Science 284:1961-1966. Pubmed: 10373108
  • Iverson, T. M., Luna-Chavez, C., Croal, L. R., Cecchini, G., Rees, D. C. (2002). "Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site." J Biol Chem 277:16124-16130. Pubmed: 11850430
  • Jones, H. M., Gunsalus, R. P. (1985). "Transcription of the Escherichia coli fumarate reductase genes (frdABCD) and their coordinate regulation by oxygen, nitrate, and fumarate." J Bacteriol 164:1100-1109. Pubmed: 2999070
  • Olsson, O., Bergstrom, S., Lindberg, F. P., Normark, S. (1983). "ampC beta-lactamase hyperproduction in Escherichia coli: natural ampicillin resistance generated by horizontal chromosomal DNA transfer from Shigella." Proc Natl Acad Sci U S A 80:7556-7560. Pubmed: 6369321
  • Yi, X., Mroczko, M., Manoj, K. M., Wang, X., Hager, L. P. (1999). "Replacement of the proximal heme thiolate ligand in chloroperoxidase with a histidine residue." Proc Natl Acad Sci U S A 96:12412-12417. Pubmed: 10535936