Fumarate reductase subunit C (P0A8Q0)

Identification
Name:Fumarate reductase subunit C
Synonyms:
  • Fumarate reductase 15 kDa hydrophobic protein
Gene Name:frdC
Enzyme Class:Not Available
Biological Properties
General Function:Energy production and conversion
Specific Function:Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Succinic acid + 1.0FAD ↔ 1.0FADH2 + 1.0Fumaric acid
ReactionCard
1.0Thumb+1.0Acceptor ↔ 1.0Thumb+1.0Reduced acceptor
1.0Succinic acid + 1.0Acceptor ↔ 1.0Fumaric acid + 1.0Reduced acceptor
ReactionCard
SMPDB Reactions:
1.0Thumb+2.0Thumb+1.0a menaquinol → 1.0Thumb+1.0a menaquinone
1.0Fumaric acid + 2.0Hydrogen ion + 1.0a menaquinol → 1.0Succinic acid + 1.0a menaquinone
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb → 1.0Menaquinone 8+1.0Thumb
1.0Fumaric acid + 1.0Menaquinol 8 → 1.0Menaquinone 8 + 1.0Succinic acid
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.02-Demethylmenaquinol 8 + 1.0Fumaric acid → 1.02-Demethylmenaquinone 8 + 1.0Succinic acid
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB211542-Demethylmenaquinol 8MetaboCard
ECMDB211552-Demethylmenaquinone 8MetaboCard
ECMDB01248FADMetaboCard
ECMDB01197FADH2MetaboCard
ECMDB00176Fumaric acidMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB02434HydroquinoneMetaboCard
ECMDB21245Menaquinol 8MetaboCard
ECMDB23060QuinoneMetaboCard
ECMDB00254Succinic acidMetaboCard
GO Classification:
Component
cell part
membrane
Gene Properties
Blattner:b4152
Gene OrientationCounterclockwise
Centisome Percentage:94.35
Left Sequence End4377400
Right Sequence End4377795
Gene Sequence:
>396 bp
ATGTGTGAAGGATATGTTGAAAAACCACTCTACTTGTTAATCGCCGAATGGATGATGGCT
GAAAATCGGTGGGTGATAGCAAGAGAGATCTCTATTCATTTCGATATTGAACACAGCAAG
GCGGTTAATACCCTGACTTATATTCTGTCGGAAGTCACAGAAATAAGCTGCGAAGTTAAG
ATGATCCCTAATAAGCTGGAAGGGCGGGGATGCCAGTGTCAGCGACTGGTTAAAGTGGTC
GATATCGATGAGCAAATTTACGCGCGCCTGCGCAATAACAGTCGGGAAAAATTAGTCGGT
GTAAGAAAGACGCCGCGTATTCCTGCCGTTCCGCTCACGGAACTTAACCGCGAGCAGAAG
TGGCAGATGATGTTGTCAAAGAGTATGCGTCGTTAA
Protein Properties
Pfam Domain Function:
Protein Residues:131
Protein Molecular Weight:15015
Protein Theoretical pI:10
PDB File:1L0V
Signaling Regions:
  • None
Transmembrane Regions:
  • 22-49
  • 66-90
  • 105-128
Protein Sequence:
>Fumarate reductase subunit C
MTTKRKPYVRPMTSTWWKKLPFYRFYMLREGTAVPAVWFSIELIFGLFALKNGPEAWAGF
VDFLQNPVIVIINLITLAAALLHTKTWFELAPKAANIIVKDEKMGPEPIIKSLWAVTVVA
TIVILFVALYW
References
External Links:
ResourceLink
Uniprot ID:P0A8Q0
Uniprot Name:FRDC_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674291
PDB ID:1L0V
Ecogene ID:EG10332
Ecocyc:EG10332
ColiBase:b4152
Kegg Gene:b4152
EchoBASE ID:EB0328
CCDB:FRDC_ECOLI
BacMap:16131977
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Burland, V., Plunkett, G. 3rd, Sofia, H. J., Daniels, D. L., Blattner, F. R. (1995). "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Nucleic Acids Res 23:2105-2119. Pubmed: 7610040
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Grundstrom, T., Jaurin, B. (1982). "Overlap between ampC and frd operons on the Escherichia coli chromosome." Proc Natl Acad Sci U S A 79:1111-1115. Pubmed: 7041115
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Iverson, T. M., Luna-Chavez, C., Cecchini, G., Rees, D. C. (1999). "Structure of the Escherichia coli fumarate reductase respiratory complex." Science 284:1961-1966. Pubmed: 10373108
  • Iverson, T. M., Luna-Chavez, C., Croal, L. R., Cecchini, G., Rees, D. C. (2002). "Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site." J Biol Chem 277:16124-16130. Pubmed: 11850430
  • Yi, X., Mroczko, M., Manoj, K. M., Wang, X., Hager, L. P. (1999). "Replacement of the proximal heme thiolate ligand in chloroperoxidase with a histidine residue." Proc Natl Acad Sci U S A 96:12412-12417. Pubmed: 10535936