NAD(P)H dehydrogenase (quinone) (P0A8G6)

Identification
Name:NAD(P)H dehydrogenase (quinone)
Synonyms:Not Available
Gene Name:wrbA
Enzyme Class:
Biological Properties
General Function:response to oxidative stress
Specific Function:It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces quinones to the hydroquinone state to prevent interaction of the semiquinone with O2 and production of superoxide. It prefers NADH over NADPH.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:
  • Ubiquinone and other terpenoid-quinone biosynthesis ec00130
KEGG Reactions:
1.0Thumb+1.0Thumb+1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb+1.0Thumb
1.0NADH + 1.0NADPH + 1.0Hydrogen ion + 1.0Quinone ↔ 1.0NAD + 1.0NADP + 1.0Hydroquinone
ReactionCard
Metabolites:
ECMDB IDNameView
GO Classification:
Function
flavin adenine dinucleotide binding
FMN binding
identical protein binding
membrane
NAD binding
NAD(P)H dehydrogenase (quinone) activity
NADP binding
negative regulation of transcription, DNA-templated
response to oxidative stress
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>597
atggctaaagttctggtgctttattattccatgtacggacatattgaaacgatggcacgc
gcagtcgctgagggtgcaagcaaagtggatggcgctgaagttgtcgttaagcgtgtaccg
gaaaccatgccgccgcaattatttgaaaaagcaggcggtaaaacgcaaactgcaccggtt
gcaaccccgcaagaactggccgattacgacgccattatttttggtacacctacccgcttt
ggcaacatgtccggtcaaatgcgtaccttcctcgaccagacgggcggcctgtgggcttcc
ggcgcactatacggaaaactggcgagcgtctttagttccaccggtactggcggcggtcag
gaacaaaccatcacatccacctggacgacccttgcgcatcacggcatggtaattgtccct
attggctacgcagcgcaggaattatttgacgtttcacaggttcgcggcggtacgccgtac
ggcgcaaccaccatcgcaggcggtgacggttcacgccagcccagccaggaagaactgtct
attgctcgttatcaaggggaatatgtcgcaggtctggcagttaaacttaacggctaa
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:198
Protein Molecular Weight:20845
Protein Theoretical pI:Not Available
PDB File:2R96
Signaling Regions:Not Available
Transmembrane Regions:Not Available
Protein Sequence:
>NAD(P)H dehydrogenase (quinone)
MAKVLVLYYSMYGHIETMARAVAEGASKVDGAEVVVKRVPETMPPQLFEKAGGKTQTAPV
ATPQELADYDAIIFGTPTRFGNMSGQMRTFLDQTGGLWASGALYGKLASVFSSTGTGGGQ
EQTITSTWTTLAHHGMVIVPIGYAAQELFDVSQVRGGTPYGATTIAGGDGSRQPSQEELS
IARYQGEYVAGLAVKLNG
References
External Links:
ResourceLink
Uniprot ID:P0A8G6
Uniprot Name:NQOR_ECOLI
PDB ID:2R96
CCDB:NQOR_ECOLI
General Reference:Not Available