| Identification |
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| Name: | Glutathione-regulated potassium-efflux system ancillary protein KefF |
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| Synonyms: | Not Available |
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| Gene Name: | kefF |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | potassium ion transport |
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| Specific Function: | Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC. Can use a wide range of substrates, including electrophilic quinones, and its function could be to reduce the redox toxicity of electrophilic quinones in parallel with acting as triggers for the KefC efflux system. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | - Ubiquinone and other terpenoid-quinone biosynthesis ec00130
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| KEGG Reactions: | |
1.0 | + | 1.0 | + | 1.0 | + | 1.0 | ↔ | 1.0 | + | 1.0 | + | 1.0 |
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| Metabolites: | |
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| GO Classification: | | Function |
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| electron carrier activity | | FMN binding | | NAD(P)H dehydrogenase (quinone) activity | | plasma membrane | | positive regulation of ion transmembrane transporter activity | | positive regulation of potassium ion transmembrane transport | | potassium ion transport |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >531
atgattcttataatttatgcgcatccgtatccgcatcattcccatgcgaataaacggatg
cttgaacaggcaaggacgctggaaggcgtcgaaattcgctctctttatcaactctatcct
gacttcaatatcgatattgccgccgagcaggaggcgctgtctcgcgccgatctgatcgtc
tggcagcatccgatgcagtggtacagcattcctccgctcctcaaactttggatcgataaa
gttttctcccacggctgggcttacggtcatggcggcacggcgctgcatggcaaacatttg
ctgtgggcggtgacgaccggcggcggggaaagccattttgaaattggtgcgcatccgggc
tttgatgtgctgtcgcagccgctacaggcgacggcaatctactgcgggctgaactggctg
ccaccgtttgccatgcactgcacctttatttgtgacgacgaaaccctcgaagggcaggcg
cgtcactataagcaacgtctgctggaatggcaggaggcccatcatggatag |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 176 |
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| Protein Molecular Weight: | 20169 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 3EYW |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Glutathione-regulated potassium-efflux system ancillary protein KefF
MILIIYAHPYPHHSHANKRMLEQARTLEGVEIRSLYQLYPDFNIDIAAEQEALSRADLIV
WQHPMQWYSIPPLLKLWIDKVFSHGWAYGHGGTALHGKHLLWAVTTGGGESHFEIGAHPG
FDVLSQPLQATAIYCGLNWLPPFAMHCTFICDDETLEGQARHYKQRLLEWQEAHHG |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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