Ureidoglycolate hydrolase (P77731)

Identification
Name:Ureidoglycolate hydrolase
Synonyms:Not Available
Gene Name:allA
Enzyme Class:
Biological Properties
General Function:Involved in ureidoglycolate hydrolase activity
Specific Function:Involved in the anaerobic utilization of allantoin. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate
Cellular Location:Cytoplasmic
SMPDB Pathways:
  • glycolate and glyoxylate degradation PW000827
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+2.0Thumb+1.0Thumb
1.0(S)-Ureidoglycolic acid + 1.0Water ↔ 1.0Glyoxylic acid + 2.0Ammonia + 1.0Carbon dioxide
ReactionCard
1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0(S)-Ureidoglycolic acid ↔ 1.0Glyoxylic acid + 1.0Urea
ReactionCard
EcoCyc Reactions:
1.0Thumb → 1.0Thumb+1.0Thumb
1.0(S)-Ureidoglycolic acid → 1.0Urea + 1.0Glyoxylic acid
ReactionCard
Complex Reactions:
2.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+2.0Thumb
2.0Hydrogen ion + 1.0Water + 1.0(S)-Ureidoglycolic acid → 1.0Carbon dioxide + 1.0Glyoxylic acid + 2.0Ammonium
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+2.0Thumb+1.0Thumb
1.0(S)-Ureidoglycolic acid + 1.0Water → 1.0Glyoxylic acid + 2.0Ammonia + 1.0Carbon dioxide
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB01005(S)-Ureidoglycolic acidMetaboCard
ECMDB00051AmmoniaMetaboCard
ECMDB21186AmmoniumMetaboCard
ECMDB04030Carbon dioxideMetaboCard
ECMDB00119Glyoxylic acidMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB04172UreaMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
ureidoglycolate hydrolase activity
Process
allantoin catabolic process
allantoin metabolic process
amine metabolic process
metabolic process
nitrogen compound metabolic process
Gene Properties
Blattner:b0505
Gene OrientationClockwise
Centisome Percentage:11.46
Left Sequence End531675
Right Sequence End532157
Gene Sequence:
>483 bp
ATGAAACTTCAGGTATTACCGTTAAGTCAGGAAGCCTTTAGTGCTTATGGCGACGTAATC
GAAACGCAGCAACGGGATTTTTTCCATATTAACAATGGCCTGGTGGAGCGTTACCACGAT
TTGGCGCTGGTTGAGATTCTTGAGCAAGACTGTACGCTTATCAGCATTAACCGCGCGCAA
CCGGCGAATCTGCCGCTGACCATTCACGAACTCGAACGTCATCCGCTGGGTACTCAGGCC
TTTATCCCGATGAAAGGTGAGGTGTTTGTGGTGGTCGTGGCGTTAGGTGACGACAAACCA
GACCTGTCAACGCTGCGGGCGTTTATCACCAACGGCGAACAGGGAGTGAATTACCATCGT
AACGTCTGGCATCACCCACTTTTCGCCTGGCAGCGCGTCACCGATTTTCTGACCATCGAT
CGCGGCGGCAGTGACAACTGTGATGTTGAAAGTATTCCTGAACAGGAACTCTGTTTTGCG
TGA
Protein Properties
Pfam Domain Function:
Protein Residues:160
Protein Molecular Weight:18169
Protein Theoretical pI:5
PDB File:1XSQ
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Ureidoglycolate hydrolase
MKLQVLPLSQEAFSAYGDVIETQQRDFFHINNGLVERYHDLALVEILEQDCTLISINRAQ
PANLPLTIHELERHPLGTQAFIPMKGEVFVVVVALGDDKPDLSTLRAFITNGEQGVNYHR
NVWHHPLFAWQRVTDFLTIDRGGSDNCDVESIPEQELCFA
References
External Links:
ResourceLink
Uniprot ID:P77731
Uniprot Name:ALLA_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674643
PDB ID:1XSQ
Ecogene ID:EG13615
Ecocyc:EG13615
ColiBase:b0505
Kegg Gene:b0505
EchoBASE ID:EB3381
CCDB:ALLA_ECOLI
BacMap:16128489
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Cusa, E., Obradors, N., Baldoma, L., Badia, J., Aguilar, J. (1999). "Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli." J Bacteriol 181:7479-7484. Pubmed: 10601204
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553