GSH-dependent disulfide bond oxidoreductase (P77526)

Identification
Name:GSH-dependent disulfide bond oxidoreductase
Synonyms:Not Available
Gene Name:yfcG
Enzyme Class:
Biological Properties
General Function:Not Available
Specific Function:Not Available
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
  • Drug metabolism - cytochrome P450 ec00982
  • Glutathione metabolism ec00480
  • Metabolism of xenobiotics by cytochrome P450 ec00980
KEGG Reactions:
1.0RX+1.0Thumb ↔ 1.0Halide+1.0R-S-Glutathione
1.0RX + 1.0Glutathione ↔ 1.0Halide + 1.0R-S-Glutathione
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb
1.01-Nitronaphthalene-7,8-oxide + 1.0Glutathione ↔ 1.01-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene
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1.0Thumb+1.0Thumb ↔ 1.0Thumb
1.01-Nitronaphthalene-7,8-oxide + 1.0Glutathione ↔ 1.01-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb
1.01-Nitronaphthalene-5,6-oxide + 1.0Glutathione ↔ 1.01-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene
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1.0Thumb+1.0Thumb ↔ 1.0Thumb
1.01-Nitronaphthalene-5,6-oxide + 1.0Glutathione ↔ 1.01-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene
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1.0Thumb+1.0Thumb ↔ 1.0Thumb
1.0Bromobenzene-3,4-oxide + 1.0Glutathione ↔ 1.03,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb
1.0Bromobenzene-2,3-oxide + 1.0Glutathione ↔ 1.02,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb
1.0Benzo[a]pyrene-4,5-oxide + 1.0Glutathione ↔ 1.04,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Benzo[a]pyrene-7,8-diol + 1.0Glutathione ↔ 1.07,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + 1.0Water
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb
1.02,2-Dichloroacetaldehyde + 1.0Glutathione ↔ 1.0S-(2,2-Dichloro-1-hydroxy)ethyl glutathione
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Hydrochloric acid
1.02,2-Dichloroacetaldehyde + 1.0Glutathione ↔ 1.0S-(2-Chloroacetyl)glutathione + 1.0Hydrochloric acid
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Hydrochloric acid
1.02-(S-Glutathionyl)acetyl chloride + 1.0Glutathione ↔ 1.02-(S-Glutathionyl)acetyl glutathione + 1.0Hydrochloric acid
ReactionCard
1.0Trichloroethene+1.0Thumb ↔ 1.0Thumb+1.0Hydrochloric acid
1.0Trichloroethene + 1.0Glutathione ↔ 1.0S-(1,2-Dichlorovinyl)glutathione + 1.0Hydrochloric acid
ReactionCard
1.01,2-Dibromoethane+1.0Thumb+1.0Thumb ↔ 1.0Thumb+2.0Hydrobromic acid
1.01,2-Dibromoethane + 1.0Glutathione + 1.0Hydrogen ion ↔ 1.0Glutathione episulfonium ion + 2.0Hydrobromic acid
ReactionCard
1.0Aflatoxin B1-exo-8,9-epoxide+1.0Thumb ↔ 1.0Aflatoxin B1exo-8,9-epoxide-GSH
1.0Aflatoxin B1-exo-8,9-epoxide + 1.0Glutathione ↔ 1.0Aflatoxin B1exo-8,9-epoxide-GSH
ReactionCard
1.0RX+1.0Thumb ↔ 1.0Thumb+1.0R-S-Glutathione
1.0RX + 1.0Glutathione ↔ 1.0Halide + 1.0R-S-Glutathione
ReactionCard
SMPDB Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Hydrochloric acid
1.0Glutathione + 1.02-(S-Glutathionyl)acetyl chloride → 1.02-(S-Glutathionyl)acetyl glutathione + 1.0Hydrochloric acid
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB20003(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthaleneMetaboCard
ECMDB20004(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthaleneMetaboCard
ECMDB20001(1R,2S)-Naphthalene 1,2-oxideMetaboCard
ECMDB20006(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthaleneMetaboCard
ECMDB200241-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthaleneMetaboCard
ECMDB200251-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthaleneMetaboCard
ECMDB200261-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthaleneMetaboCard
ECMDB200271-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthaleneMetaboCard
ECMDB200281-Nitronaphthalene-5,6-oxideMetaboCard
ECMDB200291-Nitronaphthalene-7,8-oxideMetaboCard
ECMDB200532,2-DichloroacetaldehydeMetaboCard
ECMDB200552,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzeneMetaboCard
ECMDB200342-(S-Glutathionyl)acetyl chlorideMetaboCard
ECMDB200352-(S-Glutathionyl)acetyl glutathioneMetaboCard
ECMDB200783,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzeneMetaboCard
ECMDB200964,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyreneMetaboCard
ECMDB200884-Glutathionyl cyclophosphamideMetaboCard
ECMDB201107,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyreneMetaboCard
ECMDB20118Benzo[a]pyrene-4,5-oxideMetaboCard
ECMDB20119Benzo[a]pyrene-7,8-diolMetaboCard
ECMDB20125Bromobenzene-2,3-oxideMetaboCard
ECMDB20126Bromobenzene-3,4-oxideMetaboCard
ECMDB00125GlutathioneMetaboCard
ECMDB20154Glutathione episulfonium ionMetaboCard
ECMDB23737HalideMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB20186S-(1,2-Dichlorovinyl)glutathioneMetaboCard
ECMDB20188S-(2,2-Dichloro-1-hydroxy)ethyl glutathioneMetaboCard
ECMDB20187S-(2-Chloroacetyl)glutathioneMetaboCard
ECMDB20189S-(Formylmethyl)glutathioneMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:Not Available
Gene Properties
Blattner:b2302
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>eco:b2302 yfcG; GSH-dependent disulfide bond oxidoreductase; K00799 glutathione S-transferase [EC:2.5.1.18] (N)
ATGATCGATCTCTATTTCGCCCCGACACCCAATGGTCACAAAATTACGCTGTTTCTCGAA
GAAGCAGAGCTGGATTATCGCTTGATTAAGGTAGACCTGGGGAAAGGCGGTCAGTTTCGT
CCGGAATTTTTGCGCATTTCGCCCAACAACAAAATTCCGGCAATTGTTGATCATTCTCCT
GCCGATGGCGGCGAACCGCTAAGCCTCTTTGAGTCTGGTGCCATTTTGTTGTATCTGGCT
GAGAAAACAGGACTCTTTTTGAGTCATGAAACGCGTGAGCGCGCCGCCACATTACAGTGG
TTATTCTGGCAGGTAGGCGGACTGGGGCCGATGCTTGGGCAAAATCATCATTTTAATCAC
GCAGCCCCCCAAACCATTCCTTACGCTATTGAACGTTATCAGGTTGAAACTCAGCGTCTT
TACCATGTACTGAACAAGCGGCTGGAAAACTCGCCCTGGCTGGGAGGCGAGAACTACAGC
ATTGCGGATATTGCCTGCTGGCCGTGGGTTAATGCCTGGACTCGCCAGCGAATTGACCTA
GCAATGTATCCGGCAGTCAAGAACTGGCATGAGCGGATCCGTTCGCGCCCTGCCACCGGG
CAGGCACTGCTAAAAGCACAACTCGGTGATGAGCGTTCGGATAGTTAA
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:Not Available
Protein Molecular Weight:Not Available
Protein Theoretical pI:Not Available
Signaling Regions:Not Available
Transmembrane Regions:Not Available
Protein Sequence:
>eco:b2302 yfcG; GSH-dependent disulfide bond oxidoreductase; K00799 glutathione S-transferase [EC:2.5.1.18] (A)
MIDLYFAPTPNGHKITLFLEEAELDYRLIKVDLGKGGQFRPEFLRISPNNKIPAIVDHSP
ADGGEPLSLFESGAILLYLAEKTGLFLSHETRERAATLQWLFWQVGGLGPMLGQNHHFNH
AAPQTIPYAIERYQVETQRLYHVLNKRLENSPWLGGENYSIADIACWPWVNAWTRQRIDL
AMYPAVKNWHERIRSRPATGQALLKAQLGDERSDS
References
External Links:
ResourceLink
Uniprot ID:P77526
ColiBase:b2302
Kegg Gene:b2302
EchoBASE ID:EB3863
BacMap:16130237
General Reference:Not Available