| Identification |
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| Name: | Autoinducer 2 kinase LsrK |
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| Synonyms: | Not Available |
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| Gene Name: | lsrK |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | single-species biofilm formation |
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| Specific Function: | Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3-pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity). Required for the regulation of the lsr operon and many other genes. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | |
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| KEGG Pathways: | Not Available |
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| SMPDB Reactions: | |
1.0(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran | + | 1.0 | + | 1.0 | → | 1.0Adenosine diphosphate | + | 1.0 | + | 1.0(4S)-4-hydroxy-2,3-pentanedione 5-phosphate | + | 1.0 | + | 1.0 |
| 1.0(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran + 1.0 Adenosine triphosphate + 1.0 (2R,4S)-2-Methyl-2,3,3,4-tetrahydroxytetrahydrofuran → 1.0Adenosine diphosphate + 1.0 Hydrogen ion + 1.0(4S)-4-hydroxy-2,3-pentanedione 5-phosphate + 1.0 ADP + 1.0 (4S)-4-hydroxy-2,3-pentanedione 5-phosphateReactionCard |
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| Metabolites: | |
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| GO Classification: | | Function |
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| autoinducer-2 kinase activity | | carbohydrate metabolic process | | cytoplasm | | phosphorylation | | phosphotransferase activity, alcohol group as acceptor | | quorum sensing | | single-species biofilm formation |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >1593
atggctcgactctttaccctttcagaatcaaagtactacctgatggcgctggatgcaggc
accggaagtattcgggctgtgatattcgacctggaaggcaatcaaatagcagtgggacag
gcggagtggcggcatctggcagtaccggacgttcctggttctatggaatttgatctcaac
aaaaactggcaactggcgtgtgagtgtatgcgccaggcgctgcacaacgccggcatagcc
ccggagtatatcgctgccgtttcggcatgttcgatgcgtgaaggcattgttttatataat
aatgaaggagccccgatctgggcctgcgccaatgtggatgccagagcggcacgcgaagtt
agcgaacttaaagaactgcacaacaatacctttgaaaacgaagtttatcgcgcgaccgga
caaacactggctttaagtgccatccccagattactttggctggcgcaccatcgttccgat
atttaccgtcaggcatcaaccatcaccatgatcagcgactggctggcctatatgctcagc
ggcgaactggcggtggatccctctaacgctggcaccacgggacttcttgatctaaccacc
cgtgactggaaacctgcattgctggatatggctggcctacgtgccgatattctttctcct
gtcaaagaaaccggcacattgctgggcgtggtaagttcacaagcggcggaactctgcggt
ctgaaggcgggcactccggtggtcgttggaggaggcgacgtgcagcttggttgccttggg
ttaggcgttgtgcgtccggcacaaaccgcggttcttggcggcacattctggcagcaagtt
gtaaatttagccgcgccggtgacagacccagaaatgaacgtgcgcgttaatcctcatgtt
attcctggcatggtacaagctgaatctataagcttttttaccggactcaccatgcgctgg
ttccgcgatgctttctgtgccgaagaaaaactgattgccgaacgtttaggcatcgacacc
tatacgctgctggaagagatggccagtcgggtgccgcctgggtcgtggggcgtaatgccg
atcttctccgacagaatgcgctttaaaacctggtatcacgctgcgccttcctttattaac
ttgtccattgacccggataaatgtaacaaagcgacattgttccgtgcgctggaagaaaat
gcggcgattgtatcagcgtgtaacttgcagcaaattgctgatttctcgaatattcatcct
tcatcgttagtctttgcaggcggaggttcaaaagggaaattatggagtcaaattctcgct
gatgtctcgggattacccgtcaatattccggtggtcaaagaagccactgcattaggatgt
gccattgcagctggcgtcggtgccggaattttttcatcaatggcagaaaccggagaacgc
ctggttcgctgggaacggacgcacacaccagacccggaaaagcatgaactttatcaggat
tcacgcgataagtggcaggcagtttatcaggatcagctggggctggttgatcatggactg
acgacgtcgttatggaaagcgcctgggttatag |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 530 |
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| Protein Molecular Weight: | 57544 |
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| Protein Theoretical pI: | Not Available |
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| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Autoinducer 2 kinase LsrK
MARLFTLSESKYYLMALDAGTGSIRAVIFDLEGNQIAVGQAEWRHLAVPDVPGSMEFDLN
KNWQLACECMRQALHNAGIAPEYIAAVSACSMREGIVLYNNEGAPIWACANVDARAAREV
SELKELHNNTFENEVYRATGQTLALSAIPRLLWLAHHRSDIYRQASTITMISDWLAYMLS
GELAVDPSNAGTTGLLDLTTRDWKPALLDMAGLRADILSPVKETGTLLGVVSSQAAELCG
LKAGTPVVVGGGDVQLGCLGLGVVRPAQTAVLGGTFWQQVVNLAAPVTDPEMNVRVNPHV
IPGMVQAESISFFTGLTMRWFRDAFCAEEKLIAERLGIDTYTLLEEMASRVPPGSWGVMP
IFSDRMRFKTWYHAAPSFINLSIDPDKCNKATLFRALEENAAIVSACNLQQIADFSNIHP
SSLVFAGGGSKGKLWSQILADVSGLPVNIPVVKEATALGCAIAAGVGAGIFSSMAETGER
LVRWERTHTPDPEKHELYQDSRDKWQAVYQDQLGLVDHGLTTSLWKAPGL |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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