Voltage-gated ClC-type chloride channel ClcB (P76175)

Identification
Name:Voltage-gated ClC-type chloride channel ClcB
Synonyms:Not Available
Gene Name:clcB
Enzyme Class:Not Available
Biological Properties
General Function:Involved in ion channel activity
Specific Function:Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Transports:
Transport References:
  • Orth, J. D., Conrad, T. M., Na, J., Lerman, J. A., Nam, H., Feist, A. M., Palsson, B. O. (2011). "A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011." Mol Syst Biol 7:535. Pubmed: 21988831
Metabolites:
ECMDB IDNameView
ECMDB04037ChlorideMetaboCard
ECMDB21225Hydrogen ionMetaboCard
GO Classification:
Component
cell part
membrane
Function
anion channel activity
chloride channel activity
ion channel activity
ion transmembrane transporter activity
substrate-specific transmembrane transporter activity
transmembrane transporter activity
transporter activity
voltage-gated chloride channel activity
Process
anion transport
chloride transport
establishment of localization
inorganic anion transport
ion transport
transmembrane transport
transport
Gene Properties
Blattner:b1592
Gene OrientationClockwise
Centisome Percentage:35.85
Left Sequence End1663339
Right Sequence End1664595
Gene Sequence:
>1257 bp
ATGGGTAGTAATATACATGGAATTAGTTGCACTGCAAATAATTATTTGAAACAGGCCTGG
AACGATATAAAAAATGAGTACGAAAAAAATCAAACATATTCAATCACGCTTTTTGAAAAC
ACACTGGTGTGTTTTATGCGGTTATACAATGAACTCAGACGTAAAGTAAATGAAGAGGAT
ACTCCATGTCTGGAATGTGAATCACTAGAAAAAGAATTTGAGGAAATGCAGAATGATAAT
GATCTATCATTATTTATGAGAATATTGCGTACTAATGATACACAAATTTATTCAGGGGTT
TCAGGAGGTATTACATATACTATACAATATGTTCGAGATATTGATATTGTTAGAGTGTCC
TTGCCGGGCAGAGCTTCAGAGTCTATCACAGATTTTAAAGGTTATTATTGGTATAACTTT
ATGGAGTATATTGAAAACATTAATGCGTGTGATGATGTTTTTTCTGAGTATTGTTTTGAT
GATGAAAATATAAGTGTCCAGCCAGAGCGGATAAATACGCCGGGAATATCTGATTTGGAT
TCTGACATTGATTTGTCTGGTATATCTTTTATTCAGCGTGAAACTAACCAGGCATTAGGA
TTAAAATATGCTCCTGTAGATGGCGATGGATATTGTCTGTTAAGAGCTATACTGGTTTTA
AAACAACATGATTATTCATGGGCGCTGGTCAGTTATAAGATGCAAAAGGAAGTTTACAAC
GAATTCATTAAAATGGTTGATAAAAAAACGATCGAGGCTCTTGTTGATACGGCATTCTAT
AATCTCAGGGAAGATGTAAAGACGTTATTTGGCGTTGATCTACAATCTGACAACCAAATT
CAGGGGCAGAGTAGTCTTATGTCATGGAGCTTTCTGTTTTTTAAAAAACAATTCATTGAT
AGTTGCTTGAATAACGAAAAATGTATCCTGCATTTACCCGAGTTTATATTTAATGATAAC
AAGAACTTGCTTGCTTTAGATACCGACACGTCGGATAGGATTAAAGCGGTGAAGAATTTT
CTTGTTGTTCTTTCAGATAGCATTTGCTCATTATTTATTGTTAATAGTAATGTGGCATCA
ATCTCCTTGGGGAATGAATCCTTTTCAACAGATGAAGATCTTGAGTATGGTTATTTAATG
AACACTGGCAATCATTATGACGTTTACCTCCCTCCTGAACTTTTTGCTCAGGCTTACAAG
TTAAACAATAAGGAAATGAATGCGCAACTCGACTATTTAAATCGTTATGCAATTTAA
Protein Properties
Pfam Domain Function:
Protein Residues:418
Protein Molecular Weight:44153
Protein Theoretical pI:8
Signaling Regions:
  • None
Transmembrane Regions:
  • 2-22
  • 54-74
  • 146-166
  • 178-200
  • 222-242
  • 258-278
  • 291-311
  • 316-336
  • 352-372
  • 380-400
Protein Sequence:
>Voltage-gated ClC-type chloride channel ClcB
MFHRLLIATVVGILAAFAVAGFRHAMLLLEWLFLNNDSGSLVNAATNLSPWRRLLTPALG
GLAAGLLLMGWQKFTQQRPHAPTDYMEALQTDGQFDYAASLVKSLASLLVVTSGSAIGRE
GAMILLAALAASCFAQRFTPRQEWKLWIACGAAAGMAAAYRAPLAGSLFIAEVLFGTMML
ASLGPVIISAVVALLVSNLINHSDALLYNVQLSVTVQARDYALIISTGVLAGLCGPLLLT
LMNACHRGFVSLKLAPPWQLALGGLIVGLLSLFTPAVWGNGYSTVQSFLTAPPLLMIIAG
IFLCKLCAVLASSGSGAPGGVFTPTLFIGLAIGMLYGRSLGLWFPDGEEITLLLGLTGMA
TLLAATTHAPIMSTLMICEMTGEYQLLPGLLIACVIASVISRTLHRDSIYRQHTAQHS
References
External Links:
ResourceLink
Uniprot ID:P76175
Uniprot Name:CLCB_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:4062556
Ecogene ID:EG13848
Ecocyc:EG13848
ColiBase:b1592
Kegg Gene:b1592
EchoBASE ID:EB3609
CCDB:CLCB_ECOLI
BacMap:90111303
General Reference:
  • Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Itoh, T., Kasai, H., Kashimoto, K., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Horiuchi, T., et, a. l. .. (1996). "A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map." DNA Res 3:363-377. Pubmed: 9097039
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Iyer, R., Iverson, T. M., Accardi, A., Miller, C. (2002). "A biological role for prokaryotic ClC chloride channels." Nature 419:715-718. Pubmed: 12384697