Identification |
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Name: | Trans-aconitate 2-methyltransferase |
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Synonyms: | Not Available |
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Gene Name: | tam |
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Enzyme Class: | |
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Biological Properties |
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General Function: | Involved in trans-aconitate 2-methyltransferase activity |
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Specific Function: | Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate at high affinity and of cis- aconitate, isocitrate, and citrate at lower velocities and affinities |
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Cellular Location: | Cytoplasm |
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SMPDB Pathways: | Not Available |
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KEGG Pathways: | Not Available |
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KEGG Reactions: | |
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EcoCyc Reactions: | |
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Metabolites: | ECMDB ID | Name | View |
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ECMDB23032 | (E)-3-(Methoxycarbonyl)pent-2-enedioate | MetaboCard | ECMDB21211 | E-3-Carboxy-2-pentenedioate 6-methyl ester | MetaboCard | ECMDB00939 | S-Adenosylhomocysteine | MetaboCard | ECMDB01185 | S-Adenosylmethionine | MetaboCard | ECMDB00958 | trans-Aconitic acid | MetaboCard |
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GO Classification: | Function |
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catalytic activity | methyltransferase activity | transferase activity | transferase activity, transferring one-carbon groups | Process |
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metabolic process |
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Gene Properties |
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Blattner: | b1519 |
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Gene Orientation | Clockwise |
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Centisome Percentage: | 34.60 |
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Left Sequence End | 1605370 |
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Right Sequence End | 1606128 |
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Gene Sequence: | >759 bp
ATGTCTGACTGGAACCCCTCTTTATATCTACACTTTTCCGCTGAACGATCGCGTCCGGCG
GTGGAGCTGCTTGCCAGAGTGCCGCTGGAAAATGTCGAATATGTTGCCGATCTTGGCTGT
GGCCCAGGTAACAGCACCGCCCTTCTACAACAACGTTGGCCTGCGGCCAGGATAACAGGC
ATCGACTCGTCTCCGGCGATGATTGCTGAAGCGCGCAGTGCTTTGCCAGACTGCCAGTTC
GTGGAAGCAGACATCCGCAACTGGCAACCGGTACAGGCACTCGATCTGATTTTTGCTAAT
GCCTCACTGCAATGGCTGCCCGACCACTACGAATTGTTTCCTCATCTGGTTTCTTTACTT
AATCCGCAGGGCGTGCTGGCAGTACAGATGCCAGATAACTGGCTGGAGCCGACCCATGTG
CTCATGCGCGAAGTTGCCTGGGAACAAAACTACCCGGATCGCGGGCGTGAGCCGTTGGCT
GGCGTTCATGCTTACTACGATATTTTGAGCGAAGCCGGATGTGAGGTCGATATCTGGCGA
ACCACCTACTATCACCAGATGCCGTCACACCAGGCGATTATCGATTGGGTGACTGCCACT
GGATTACGTCCGTGGTTACAGGATCTGACCGAGAGCGAACAGCAGCTTTTTCTTAAGCGC
TACCATCAGATGCTGGAAGAGCAGTATCCACTGCAAGAGAACGGACAGATACTGCTGGCA
TTTCCGCGTCTGTTTATTGTTGCCCGGCGTATGGAGTAA |
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Protein Properties |
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Pfam Domain Function: | |
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Protein Residues: | 252 |
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Protein Molecular Weight: | 29006 |
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Protein Theoretical pI: | 5 |
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Signaling Regions: | |
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Transmembrane Regions: | |
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Protein Sequence: | >Trans-aconitate 2-methyltransferase
MSDWNPSLYLHFSAERSRPAVELLARVPLENVEYVADLGCGPGNSTALLQQRWPAARITG
IDSSPAMIAEARSALPDCQFVEADIRNWQPVQALDLIFANASLQWLPDHYELFPHLVSLL
NPQGVLAVQMPDNWLEPTHVLMREVAWEQNYPDRGREPLAGVHAYYDILSEAGCEVDIWR
TTYYHQMPSHQAIIDWVTATGLRPWLQDLTESEQQLFLKRYHQMLEEQYPLQENGQILLA
FPRLFIVARRME |
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References |
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External Links: | |
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General Reference: | - Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Cai, H., Clarke, S. (1999). "A novel methyltransferase catalyzes the methyl esterification of trans-aconitate in Escherichia coli." J Biol Chem 274:13470-13479. Pubmed: 10224113
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
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