S-Adenosylmethionine (ECMDB01185) (M2MDB000289)

General function:

Coenzyme transport and metabolism

Specific function:

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1

Gene Name:

hemX

Uniprot ID:

P09127

Molecular weight:

42963

Reactions

General function:

Involved in protein-L-isoaspartate (D-aspartate) O-methyltransferase activity

Specific function:

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. This enzyme does not act on D-aspartyl residues

Gene Name:

pcm

Uniprot ID:

P0A7A5

Molecular weight:

23258

Reactions

General function:

Involved in adenosylmethionine decarboxylase activity

Specific function:

Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine

Gene Name:

speD

Uniprot ID:

P0A7F6

Molecular weight:

30384

Reactions

General function:

Involved in methionine adenosyltransferase activity

Specific function:

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. Is essential for growth

Gene Name:

metK

Uniprot ID:

P0A817

Molecular weight:

41951

Reactions

General function:

Involved in RNA binding

Specific function:

Specifically methylates guanosine-37 in various tRNAs

Gene Name:

trmD

Uniprot ID:

P0A873

Molecular weight:

28422

Reactions

General function:

Involved in lipid biosynthetic process

Specific function:

Transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge

Gene Name:

cfa

Uniprot ID:

P0A9H7

Molecular weight:

43909

Reactions

General function:

Involved in catalytic activity

Specific function:

Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

pflA

Uniprot ID:

P0A9N4

Molecular weight:

28204

Reactions

General function:

Involved in [formate-C-acetyltransferase]-activating enzyme activity

Specific function:

Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

nrdG

Uniprot ID:

P0A9N8

Molecular weight:

17446

General function:

Involved in nucleic acid binding

Specific function:

Specifically methylates the guanosine in position 966 of 16S rRNA in the assembled 30S particle

Gene Name:

rsmD

Uniprot ID:

P0ADX9

Molecular weight:

21677

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme

Gene Name:

cysG

Uniprot ID:

P0AEA8

Molecular weight:

49951

Reactions

General function:

Involved in DNA binding

Specific function:

This methylase recognizes the double-stranded sequence CCWGG, causes specific methylation on C-2 on both strands

Gene Name:

dcm

Uniprot ID:

P0AED9

Molecular weight:

53464

Reactions

General function:

Involved in transaminase activity

Specific function:

Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor

Gene Name:

bioA

Uniprot ID:

P12995

Molecular weight:

47335

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism

Gene Name:

bioB

Uniprot ID:

P12996

Molecular weight:

38648

Reactions

General function:

Involved in 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

Specific function:

S-adenosyl-L-methionine + 3- demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9

Gene Name:

ubiG

Uniprot ID:

P17993

Molecular weight:

26555

Reactions

General function:

Involved in coproporphyrinogen oxidase activity

Specific function:

Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX

Gene Name:

hemN

Uniprot ID:

P32131

Molecular weight:

52729

Reactions

General function:

Involved in iron-sulfur cluster binding

Specific function:

Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

pflC

Uniprot ID:

P32675

Molecular weight:

32429

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Specifically methylates the guanosine in position 745 of 23S rRNA

Gene Name:

rlmA

Uniprot ID:

P36999

Molecular weight:

30419

Reactions

General function:

Involved in nucleic acid binding

Specific function:

S-adenosyl-L-methionine + DNA adenine = S- adenosyl-L-homocysteine + DNA 6-methylaminopurine

Gene Name:

yfcB

Uniprot ID:

P39199

Molecular weight:

35001

Reactions

General function:

Involved in nucleic acid binding

Specific function:

Specifically methylates the guanosine in position 1207 of 16S rRNA in the 30S particle

Gene Name:

rsmC

Uniprot ID:

P39406

Molecular weight:

37624

Reactions

General function:

Involved in nucleic acid binding

Specific function:

Specifically methylates the guanosine in position 1835 (m2G1835) of 23S rRNA

Gene Name:

rlmG

Uniprot ID:

P42596

Molecular weight:

42331

Reactions

General function:

Involved in coproporphyrinogen oxidase activity

Specific function:

Not Available

Gene Name:

yggW

Uniprot ID:

P52062

Molecular weight:

42584

General function:

Involved in catalytic activity

Specific function:

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. Free octanoate is not a substrate for lipA

Gene Name:

lipA

Uniprot ID:

P60716

Molecular weight:

36071

Reactions

General function:

Involved in rRNA (adenine-N6-)-methyltransferase activity

Specific function:

Specifically methylates the adenine in position 1618 of 23S rRNA

Gene Name:

rlmF

Uniprot ID:

P75782

Molecular weight:

34226

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

ybiY

Uniprot ID:

P75794

Molecular weight:

33038

Reactions

General function:

Involved in trans-aconitate 2-methyltransferase activity

Specific function:

Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate at high affinity and of cis- aconitate, isocitrate, and citrate at lower velocities and affinities

Gene Name:

tam

Uniprot ID:

P76145

Molecular weight:

29006

Reactions

General function:

Involved in homocysteine S-methyltransferase activity

Specific function:

Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine

Gene Name:

mmuM

Uniprot ID:

Q47690

Molecular weight:

33422

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S

Gene Name:

thiG

Uniprot ID:

P30139

Molecular weight:

26896

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the radical-mediated cleavage of tyrosine to dehydroglycine and p-cresol

Gene Name:

thiH

Uniprot ID:

P30140

Molecular weight:

43320

Reactions

General function:

Involved in thiamine biosynthetic process

Specific function:

Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction

Gene Name:

thiC

Uniprot ID:

P30136

Molecular weight:

70850

Reactions

General function:

Involved in methyltransferase activity

Specific function:

Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)

Gene Name:

ubiE

Uniprot ID:

P0A887

Molecular weight:

28073

Reactions

General function:

Involved in biotin biosynthetic process

Specific function:

BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin

Gene Name:

bioC

Uniprot ID:

P12999

Molecular weight:

28276

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

rlmL

Uniprot ID:

P75864

Molecular weight:

Not Available

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Methylates the translation termination release factor RF1/PrfA on 'Gln-235' and RF2/PrfB on 'Gln-252'

Gene Name:

hemK

Uniprot ID:

P0ACC1

Molecular weight:

30975

Reactions

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Has also a DNA glycosylase/AP lyase activity that removes C mispaired with oxidized T from DNA, and may play a role in protection of DNA against oxidative stress

Gene Name:

rsmA

Uniprot ID:

P06992

Molecular weight:

30420

Reactions

General function:

tRNA methylthiolation

Specific function:

Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.

Gene Name:

miaB

Uniprot ID:

P0AEI1

Molecular weight:

53662

Reactions

General function:

RNA modification

Specific function:

Catalyzes the methylthiolation of the residue Asp-89 of ribosomal protein S12.

Gene Name:

rimO

Uniprot ID:

P0AEI4

Molecular weight:

49581

Reactions