ECMDB

Identification

Name:

Xanthine permease XanQ

Synonyms:

Not Available

Gene Name:

xanQ

Enzyme Class:

Not Available

Biological Properties

General Function:

Involved in transporter activity

Specific Function:

Specific, proton motive force-dependent high-affinity transporter for xanthine

Cellular Location:

Cell inner membrane; Multi-pass membrane protein

SMPDB Pathways:

Not Available

KEGG Pathways:

Not Available

Transports:

Transport References:

Orth, J. D., Conrad, T. M., Na, J., Lerman, J. A., Nam, H., Feist, A. M., Palsson, B. O. (2011). "A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011." Mol Syst Biol 7:535. Pubmed: 21988831
Uniprot Consortium (2012). "Reorganizing the protein space at the Universal Protein Resource (UniProt)." Nucleic Acids Res 40:D71-D75. Pubmed: 22102590

Metabolites:

ECMDB ID	Name	View
ECMDB21225	Hydrogen ion	MetaboCard
ECMDB00292	Xanthine	MetaboCard

GO Classification:

Component
cell part
membrane
Function
transporter activity
Process
establishment of localization
transmembrane transport
transport

Gene Properties

Blattner:

b2882

Gene Orientation

Clockwise

Centisome Percentage:

65.14

Left Sequence End

3022373

Right Sequence End

3023773

Gene Sequence:

>1401 bp
ATGGGGCAATCATCGCAACCACATGAGTTAGGCGGCGGGCTGAAGTCACGCCACGTCACC
ATGTTGTCTATTGCCGGTGTTATCGGCGCAAGTCTGTTTGTCGGTTCCAGCGTCGCCATC
GCCGAAGCGGGCCCGGCGGTATTACTGGCCTATCTGTTCGCCGGGCTACTGGTGGTTATG
ATTATGCGGATGTTGGCGGAAATGGCGGTTGCCACGCCCGATACCGGTTCGTTTTCCACC
TATGCCGATAAAGCCATTGGTCGCTGGGCGGGCTATACCATCGGCTGGTTGTACTGGTGG
TTTTGGGTACTGGTTATCCCGCTGGAAGCCAACATCGCCGCCATGATCCTGCACTCATGG
GTTCCAGGCATTCCCATCTGGTTATTTTCCCTCGTCATTACCCTCGCCTTAACTGGCAGT
AACTTATTAAGCGTTAAAAACTACGGCGAATTTGAGTTCTGGCTGGCGCTGTGCAAAGTC
ATCGCTATCCTGGCCTTTATTTTCCTTGGTGCAGTCGCAATTAGCGGTTTTTACCCGTAT
GCCGAAGTGAGCGGGATCTCAAGATTGTGGGATAGCGGCGGCTTTATGCCCAACGGTTTC
GGTGCGGTATTAAGCGCGATGTTGATCACCATGTTCTCGTTTATGGGCGCAGAAATTGTC
ACCATTGCCGCCGCGGAATCCGACACGCCGGAAAAACATATTGTCCGCGCCACCAACTCG
GTTATCTGGCGTATTTCTATCTTCTATTTATGTTCTATTTTTGTCGTCGTGGCATTAATT
CCGTGGAATATGCCCGGACTAAAAGCCGTCGGTTCTTATCGCTCGGTACTGGAATTGCTC
AATATTCCCCATGCGAAATTAATCATGGACTGCGTGATATTACTTTCCGTAACCAGTTGC
CTGAACTCGGCGCTGTATACCGCGTCAAGGATGCTCTACTCCTTAAGTCGTCGCGGTGAT
GCTCCCGCGGTAATGGGTAAAATCAACCGCAGTAAAACCCCGTACGTGGCGGTGTTACTC
TCCACCGGCGCGGCATTCTTAACGGTGGTGGTGAACTATTACGCGCCTGCGAAGGTATTT
AAATTTCTGATCGACAGCTCCGGCGCTATCGCCCTGCTGGTTTATTTAGTCATCGCCGTT
TCACAGTTGCGGATGCGCAAAATTCTGCGAGCAGAAGGAAGCGAAATTCGCTTGCGAATG
TGGCTTTATCCGTGGCTCACCTGGCTAGTCATCGGCTTTATTACCTTTGTGTTGGTAGTG
ATGCTATTCCGTCCGGCGCAACAGTTAGAAGTGATCTCCACCGGCTTATTAGCGATAGGG
ATTATCTGTACCGTGCCAATTATGGCTCGCTGGAAAAAGCTGGTATTGTGGCAAAAAACA
CCCGTTCATAATACGCGCTGA

Protein Properties

Pfam Domain Function:

Xan_ur_permease (PF00860 )

Protein Residues:

466

Protein Molecular Weight:

49108

Protein Theoretical pI:

Signaling Regions:

None

Transmembrane Regions:

26-46
56-76
81-101
121-141
152-172
181-201
211-231
259-279
299-319
343-363
365-384
426-446

Protein Sequence:

>Xanthine permease XanQ
MSDINHAGSDLIFELEDRPPFHQALVGAITHLLAIFVPMVTPALIVGAALQLSAETTAYL
VSMAMIASGIGTWLQVNRYGIVGSGLLSIQSVNFSFVTVMIALGSSMKSDGFHEELIMSS
LLGVSFVGAFLVVGSSFILPYLRRVITPTVSGIVVLMIGLSLIKVGIIDFGGGFAAKSSG
TFGNYEHLGVGLLVLIVVIGFNCCRSPLLRMGGIAIGLCVGYIASLCLGMVDFSSMRNLP
LITIPHPFKYGFSFSFHQFLVVGTIYLLSVLEAVGDITATAMVSRRPIQGEEYQSRLKGG
VLADGLVSVIASAVGSLPLTTFAQNNGVIQMTGVASRYVGRTIAVMLVILGLFPMIGGFF
TTIPSAVLGGAMTLMFSMIAIAGIRIIITNGLKRRETLIVATSLGLGLGVSYDPEIFKIL
PASIYVLVENPICAGGLTAILLNIILPGGYRQENVLPGITSAEEMD

References

External Links:

Resource	Link
Uniprot ID:	P67444
Uniprot Name:	XANQ_ECOLI
GenBank Gene ID:	AP009048
Genebank Protein ID:	1800049
Ecogene ID:	EG13065
Ecocyc:	EG13065
ColiBase:	b2882
Kegg Gene:	b2882
EchoBASE ID:	EB2877
CCDB:	XANQ_ECOLI
BacMap:	90111507

General Reference:

Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
Karatza, P., Frillingos, S. (2005). "Cloning and functional characterization of two bacterial members of the NAT/NCS2 family in Escherichia coli." Mol Membr Biol 22:251-261. Pubmed: 16096267
Karena, E., Frillingos, S. (2009). "Role of intramembrane polar residues in the YgfO xanthine permease: HIS-31 and ASN-93 are crucial for affinity and specificity, and ASP-304 and GLU-272 are irreplaceable." J Biol Chem 284:24257-24268. Pubmed: 19581302
Papakostas, K., Georgopoulou, E., Frillingos, S. (2008). "Cysteine-scanning analysis of putative helix XII in the YgfO xanthine permease: ILE-432 and ASN-430 are important." J Biol Chem 283:13666-13678. Pubmed: 18359771

Xanthine permease XanQ (P67444)