Xanthine permease XanQ (P67444)

Identification
Name:Xanthine permease XanQ
Synonyms:Not Available
Gene Name:xanQ
Enzyme Class:Not Available
Biological Properties
General Function:Involved in transporter activity
Specific Function:Specific, proton motive force-dependent high-affinity transporter for xanthine
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Transports:
Transport References:
  • Orth, J. D., Conrad, T. M., Na, J., Lerman, J. A., Nam, H., Feist, A. M., Palsson, B. O. (2011). "A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011." Mol Syst Biol 7:535. Pubmed: 21988831
  • Uniprot Consortium (2012). "Reorganizing the protein space at the Universal Protein Resource (UniProt)." Nucleic Acids Res 40:D71-D75. Pubmed: 22102590
Metabolites:
ECMDB IDNameView
ECMDB21225Hydrogen ionMetaboCard
ECMDB00292XanthineMetaboCard
GO Classification:
Component
cell part
membrane
Function
transporter activity
Process
establishment of localization
transmembrane transport
transport
Gene Properties
Blattner:b2882
Gene OrientationClockwise
Centisome Percentage:65.14
Left Sequence End3022373
Right Sequence End3023773
Gene Sequence:
>1401 bp
ATGGGGCAATCATCGCAACCACATGAGTTAGGCGGCGGGCTGAAGTCACGCCACGTCACC
ATGTTGTCTATTGCCGGTGTTATCGGCGCAAGTCTGTTTGTCGGTTCCAGCGTCGCCATC
GCCGAAGCGGGCCCGGCGGTATTACTGGCCTATCTGTTCGCCGGGCTACTGGTGGTTATG
ATTATGCGGATGTTGGCGGAAATGGCGGTTGCCACGCCCGATACCGGTTCGTTTTCCACC
TATGCCGATAAAGCCATTGGTCGCTGGGCGGGCTATACCATCGGCTGGTTGTACTGGTGG
TTTTGGGTACTGGTTATCCCGCTGGAAGCCAACATCGCCGCCATGATCCTGCACTCATGG
GTTCCAGGCATTCCCATCTGGTTATTTTCCCTCGTCATTACCCTCGCCTTAACTGGCAGT
AACTTATTAAGCGTTAAAAACTACGGCGAATTTGAGTTCTGGCTGGCGCTGTGCAAAGTC
ATCGCTATCCTGGCCTTTATTTTCCTTGGTGCAGTCGCAATTAGCGGTTTTTACCCGTAT
GCCGAAGTGAGCGGGATCTCAAGATTGTGGGATAGCGGCGGCTTTATGCCCAACGGTTTC
GGTGCGGTATTAAGCGCGATGTTGATCACCATGTTCTCGTTTATGGGCGCAGAAATTGTC
ACCATTGCCGCCGCGGAATCCGACACGCCGGAAAAACATATTGTCCGCGCCACCAACTCG
GTTATCTGGCGTATTTCTATCTTCTATTTATGTTCTATTTTTGTCGTCGTGGCATTAATT
CCGTGGAATATGCCCGGACTAAAAGCCGTCGGTTCTTATCGCTCGGTACTGGAATTGCTC
AATATTCCCCATGCGAAATTAATCATGGACTGCGTGATATTACTTTCCGTAACCAGTTGC
CTGAACTCGGCGCTGTATACCGCGTCAAGGATGCTCTACTCCTTAAGTCGTCGCGGTGAT
GCTCCCGCGGTAATGGGTAAAATCAACCGCAGTAAAACCCCGTACGTGGCGGTGTTACTC
TCCACCGGCGCGGCATTCTTAACGGTGGTGGTGAACTATTACGCGCCTGCGAAGGTATTT
AAATTTCTGATCGACAGCTCCGGCGCTATCGCCCTGCTGGTTTATTTAGTCATCGCCGTT
TCACAGTTGCGGATGCGCAAAATTCTGCGAGCAGAAGGAAGCGAAATTCGCTTGCGAATG
TGGCTTTATCCGTGGCTCACCTGGCTAGTCATCGGCTTTATTACCTTTGTGTTGGTAGTG
ATGCTATTCCGTCCGGCGCAACAGTTAGAAGTGATCTCCACCGGCTTATTAGCGATAGGG
ATTATCTGTACCGTGCCAATTATGGCTCGCTGGAAAAAGCTGGTATTGTGGCAAAAAACA
CCCGTTCATAATACGCGCTGA
Protein Properties
Pfam Domain Function:
Protein Residues:466
Protein Molecular Weight:49108
Protein Theoretical pI:7
Signaling Regions:
  • None
Transmembrane Regions:
  • 26-46
  • 56-76
  • 81-101
  • 121-141
  • 152-172
  • 181-201
  • 211-231
  • 259-279
  • 299-319
  • 343-363
  • 365-384
  • 426-446
Protein Sequence:
>Xanthine permease XanQ
MSDINHAGSDLIFELEDRPPFHQALVGAITHLLAIFVPMVTPALIVGAALQLSAETTAYL
VSMAMIASGIGTWLQVNRYGIVGSGLLSIQSVNFSFVTVMIALGSSMKSDGFHEELIMSS
LLGVSFVGAFLVVGSSFILPYLRRVITPTVSGIVVLMIGLSLIKVGIIDFGGGFAAKSSG
TFGNYEHLGVGLLVLIVVIGFNCCRSPLLRMGGIAIGLCVGYIASLCLGMVDFSSMRNLP
LITIPHPFKYGFSFSFHQFLVVGTIYLLSVLEAVGDITATAMVSRRPIQGEEYQSRLKGG
VLADGLVSVIASAVGSLPLTTFAQNNGVIQMTGVASRYVGRTIAVMLVILGLFPMIGGFF
TTIPSAVLGGAMTLMFSMIAIAGIRIIITNGLKRRETLIVATSLGLGLGVSYDPEIFKIL
PASIYVLVENPICAGGLTAILLNIILPGGYRQENVLPGITSAEEMD
References
External Links:
ResourceLink
Uniprot ID:P67444
Uniprot Name:XANQ_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:1800049
Ecogene ID:EG13065
Ecocyc:EG13065
ColiBase:b2882
Kegg Gene:b2882
EchoBASE ID:EB2877
CCDB:XANQ_ECOLI
BacMap:90111507
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Karatza, P., Frillingos, S. (2005). "Cloning and functional characterization of two bacterial members of the NAT/NCS2 family in Escherichia coli." Mol Membr Biol 22:251-261. Pubmed: 16096267
  • Karena, E., Frillingos, S. (2009). "Role of intramembrane polar residues in the YgfO xanthine permease: HIS-31 and ASN-93 are crucial for affinity and specificity, and ASP-304 and GLU-272 are irreplaceable." J Biol Chem 284:24257-24268. Pubmed: 19581302
  • Papakostas, K., Georgopoulou, E., Frillingos, S. (2008). "Cysteine-scanning analysis of putative helix XII in the YgfO xanthine permease: ILE-432 and ASN-430 are important." J Biol Chem 283:13666-13678. Pubmed: 18359771