Methylmalonyl-CoA decarboxylase (P52045)

Identification
Name:Methylmalonyl-CoA decarboxylase
Synonyms:
  • MMCD
  • Transcarboxylase
Gene Name:mmcD
Enzyme Class:
Biological Properties
General Function:Involved in catalytic activity
Specific Function:(S)-methylmalonyl-CoA = propanoyl-CoA + CO(2)
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Hydrogen ion + 1.0(S)-Methylmalonyl-CoA ↔ 1.0Carbon dioxide + 1.0Propionyl-CoA
ReactionCard
1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0(S)-Methylmalonyl-CoA ↔ 1.0Propionyl-CoA + 1.0Carbon dioxide
ReactionCard
SMPDB Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Propionyl-CoA+1.0Thumb
1.0Methylmalonyl-CoA + 1.0Hydrogen ion → 1.0Carbon dioxide + 1.0Propionyl-CoA + 1.0Propionyl-CoA
ReactionCard
1.0R-Methylmalonyl-CoA+1.0Thumb → 1.0Thumb+1.0Thumb
1.0R-Methylmalonyl-CoA + 1.0Hydrogen ion → 1.0Propionyl-CoA + 1.0Carbon dioxide
ReactionCard
Complex Reactions:
1.0Thumb → 1.0Thumb+1.0Thumb
1.0(S)-Methylmalonyl-CoA → 1.0Propionyl-CoA + 1.0Carbon dioxide
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB02310(S)-Methylmalonyl-CoAMetaboCard
ECMDB04030Carbon dioxideMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB24063Methylmalonyl-CoAMetaboCard
ECMDB01275Propionyl-CoAMetaboCard
GO Classification:
Function
catalytic activity
Process
metabolic process
Gene Properties
Blattner:b2919
Gene OrientationClockwise
Centisome Percentage:66.00
Left Sequence End3062015
Right Sequence End3062800
Gene Sequence:
>786 bp
ATGAATTCAAAAAAGCTTTGTTGCATATGTGTGTTATTCTCGCTGCTTGCAGGATGTGCC
TCTGAATCTTCTATTGATGAAAAGAAGAAAAAAGCTCAAGTCACACAAAGTAATATTAAT
AAAAACACTCCCCAGCAACTGACAGACAAAGATTTATTCGGTAATGAAACCACTCTGGCC
GTATCCGAAGAGGATATTCAAGCTGCGCTTGATGGAGATGAGTTCCGCGTTCCCCTTAAT
TCTCCTGTAATACTTGTTCAATCCGGCAACCGCGCACCGGAAACCATTATGCAGGAGGAG
ATGCGAAAATATTATACTGTTTCCACATTCTCTGGTATCCCGGACAGGCAAAAGCCTCTG
ACTTGTAACAAAAACAAAGATAAAAATGAGAACGAGGATGTTGCCAGTGCTGAGAATATG
AACTGGATGCAGGCACTGCGTTTTGTGGCTGCAAAAGGACATCAGAAAGCGATTATTGTT
TACCAGGATATGTTGCAGACAGGAAAATATGACTCTGCGCTGAAATCAACAGTATGGTCC
GACTATAAAAATGACAAACTCACTGACGCTATCTCCCTGCGCTACCTGGTACGTTTCACG
CTGGTGGATGTGGCAACAGGTGAGTGGGCTACCTGGTCGCCGGTGAATTATGAATATAAA
GTGCTTCCACCATTGCCCGACAAGAATGAAGCCAGTACGACTGATATGACAGAGCAGCAA
ATCATGCAACTTAAGCAAAAGACCTATAAAGCGATGGTAAAAGATTTGGTTAACCGCTAT
CAATAA
Protein Properties
Pfam Domain Function:
Protein Residues:261
Protein Molecular Weight:29172
Protein Theoretical pI:6
PDB File:1EF9
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Methylmalonyl-CoA decarboxylase
MSYQYVNVVTINKVAVIEFNYGRKLNALSKVFIDDLMQALSDLNRPEIRCIILRAPSGSK
VFSAGHDIHELPSGGRDPLSYDDPLRQITRMIQKFPKPIISMVEGSVWGGAFEMIMSSDL
IIAASTSTFSMTPVNLGVPYNLVGIHNLTRDAGFHIVKELIFTASPITAQRALAVGILNH
VVEVEELEDFTLQMAHHISEKAPLAIAVIKEELRVLGEAHTMNSDEFERIQGMRRAVYDS
EDYQEGMNAFLEKRKPNFVGH
References
External Links:
ResourceLink
Uniprot ID:P52045
Uniprot Name:MMCD_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:4902953
PDB ID:1EF9
Ecogene ID:EG12972
Ecocyc:EG12972
ColiBase:b2919
Kegg Gene:b2919
EchoBASE ID:EB2799
CCDB:MMCD_ECOLI
BacMap:90111512
General Reference:
  • Benning, M. M., Haller, T., Gerlt, J. A., Holden, H. M. (2000). "New reactions in the crotonase superfamily: structure of methylmalonyl CoA decarboxylase from Escherichia coli." Biochemistry 39:4630-4639. Pubmed: 10769118
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Haller, T., Buckel, T., Retey, J., Gerlt, J. A. (2000). "Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli." Biochemistry 39:4622-4629. Pubmed: 10769117
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553