Hydroxypyruvate isomerase (P30147)

Identification
Name:Hydroxypyruvate isomerase
Synonyms:Not Available
Gene Name:hyi
Enzyme Class:
Biological Properties
General Function:Carbohydrate transport and metabolism
Specific Function:Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde)
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb
1.0Hydroxypyruvic acid ↔ 1.0Tartronate semialdehyde
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0Thumb
1.0Hydroxypyruvic acid ↔ 1.0Tartronate semialdehyde
ReactionCard
Complex Reactions:
1.0Thumb → 1.0Thumb
1.0Hydroxypyruvic acid → 1.0Tartronate semialdehyde
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB01352Hydroxypyruvic acidMetaboCard
ECMDB06938Tartronate semialdehydeMetaboCard
GO Classification:Not Available
Gene Properties
Blattner:b0508
Gene OrientationClockwise
Centisome Percentage:11.53
Left Sequence End534934
Right Sequence End535710
Gene Sequence:
>777 bp
ATGTTACGTTTCTCTGCTAATTTATCGATGTTATTTGGAGAATATGATTTTCTCGCCCGT
TTTGAGAAAGCTGCGCAGTGTGGTTTTCGCGGCGTTGAATTTATGTTTCCTTATGACTAC
GACATTGAAGAATTAAAACATGTGCTGGCGAGTAATAAACTCGAACATACGCTGCACAAT
TTACCGGCGGGTGACTGGGCGGCGGGGGAGCGCGGTATTGCCTGTATTCCTGGCCGTGAA
GAAGAGTTTCGGGATGGCGTAGCAGCAGCGATTCGTTATGCCCGTGCGCTGGGTAATAAA
AAAATTAACTGTCTGGTCGGTAAAACGCCGGCTGGTTTCAGCAGTGAACAGATTCACGCA
ACGCTTGTAGAAAACCTGCGTTATGCCGCGAATATGCTGATGAAAGAAGATATTTTATTA
CTGATTGAACCTATTAACCATTTTGATATTCCTGGTTTCCATCTCACCGGAACTCGGCAG
GCGCTGAAATTGATTGATGATGTTGGTTGCTGCAATTTGAAAATTCAGTATGACATTTAT
CATATGCAGCGGATGGAAGGTGAATTAACCAACACCATGACTCAGTGGGCTGATAAAATT
GGTCACCTGCAAATTGCCGATAATCCGCATCGCGGCGAACCGGGAACCGGAGAAATTAAT
TATGATTATCTCTTTAAGGTAATCGAAAATTCTGACTACAACGGTTGGGTTGGGTGTGAA
TATAAACCCCAAACCACCACGGAAGCCGGTTTACGCTGGATGGATCCGTACCGTTAA
Protein Properties
Pfam Domain Function:
Protein Residues:258
Protein Molecular Weight:29377
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Hydroxypyruvate isomerase
MLRFSANLSMLFGEYDFLARFEKAAQCGFRGVEFMFPYDYDIEELKHVLASNKLEHTLHN
LPAGDWAAGERGIACIPGREEEFRDGVAAAIRYARALGNKKINCLVGKTPAGFSSEQIHA
TLVENLRYAANMLMKEDILLLIEPINHFDIPGFHLTGTRQALKLIDDVGCCNLKIQYDIY
HMQRMEGELTNTMTQWADKIGHLQIADNPHRGEPGTGEINYDYLFKVIENSDYNGWVGCE
YKPQTTTEAGLRWMDPYR
References
External Links:
ResourceLink
Uniprot ID:P30147
Uniprot Name:HYI_ECOLI
GenBank Gene ID:AB028043
Genebank Protein ID:6683062
Ecogene ID:EG11584
Ecocyc:EG11584
ColiBase:b0508
Kegg Gene:b0508
EchoBASE ID:EB1543
CCDB:HYI_ECOLI
BacMap:16128492
General Reference:
  • Ashiuchi, M., Misono, H. (1999). "Biochemical evidence that Escherichia coli hyi (orf b0508, gip) gene encodes hydroxypyruvate isomerase." Biochim Biophys Acta 1435:153-159. Pubmed: 10561547
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Chang, Y. Y., Wang, A. Y., Cronan, J. E. Jr (1993). "Molecular cloning, DNA sequencing, and biochemical analyses of Escherichia coli glyoxylate carboligase. An enzyme of the acetohydroxy acid synthase-pyruvate oxidase family." J Biol Chem 268:3911-3919. Pubmed: 8440684
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553