Deoxycytidine triphosphate deaminase (P28248)

Identification
Name:Deoxycytidine triphosphate deaminase
Synonyms:
  • dCTP deaminase
Gene Name:dcd
Enzyme Class:
Biological Properties
General Function:Involved in dCTP deaminase activity
Specific Function:dCTP + H(2)O = dUTP + NH(3)
Cellular Location:Cytoplasmic
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Cytidine triphosphate + 1.0Water ↔ 1.0Uridine triphosphate + 1.0Ammonia
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0dCTP + 1.0Water ↔ 1.0Deoxyuridine triphosphate + 1.0Ammonia
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0Water + 1.0dCTP → 1.0Ammonia + 1.0Deoxyuridine triphosphate
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0Water + 1.0dCTP → 1.0Ammonia + 1.0Deoxyuridine triphosphate
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0dCTP + 1.0Hydrogen ion + 1.0Water → 1.0Deoxyuridine triphosphate + 1.0Ammonium
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00051AmmoniaMetaboCard
ECMDB21186AmmoniumMetaboCard
ECMDB00082Cytidine triphosphateMetaboCard
ECMDB00998dCTPMetaboCard
ECMDB01191Deoxyuridine triphosphateMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB00285Uridine triphosphateMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
binding
catalytic activity
dCTP deaminase activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
protein binding
Process
cellular nitrogen compound metabolic process
dUTP biosynthetic process
dUTP metabolic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
pyrimidine deoxyribonucleoside triphosphate biosynthetic process
pyrimidine deoxyribonucleoside triphosphate metabolic process
pyrimidine nucleoside triphosphate biosynthetic process
pyrimidine nucleoside triphosphate metabolic process
pyrimidine nucleotide biosynthetic process
pyrimidine nucleotide metabolic process
Gene Properties
Blattner:b2065
Gene OrientationCounterclockwise
Centisome Percentage:46.12
Left Sequence End2139658
Right Sequence End2140239
Gene Sequence:
>582 bp
ATGACTGACTACCTGTTACTGTTTGTCGGAACTGTACTGGTCAATAACTTTGTACTGGTC
AAGTTTCTCGGTCTCTGTCCGTTTATGGGGGTTTCCAAAAAACTGGAAACCGCGATGGGC
ATGGGGCTGGCAACAACGTTTGTGATGACGCTGGCGTCTATTTGCGCCTGGCTTATCGAT
ACGTGGATTTTGATCCCACTTAATCTGATTTACCTGCGCACCCTGGCATTTATTCTGGTG
ATTGCTGTGGTCGTGCAGTTCACCGAGATGGTGGTGCGCAAAACCAGCCCGGTGCTTTAC
CGTCTGCTGGGGATTTTTTTGCCGCTTATCACCACCAACTGTGCAGTGCTCGGCGTGGCG
TTGCTGAATATCAATCTCGGGCACAATTTCTTGCAGTCGGCGCTGTACGGTTTTTCCGCC
GCTGTCGGTTTCTCGCTGGTGATGGTGCTCTTCGCCGCCATCCGCGAACGCCTTGCTGTG
GCTGATGTCCCGGCACCTTTTCGCGGTAATGCCATTGCGTTAATTACCGCAGGTCTTATG
TCTCTGGCCTTTATGGGCTTTAGTGGTTTGGTGAAGTTGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:193
Protein Molecular Weight:21249
Protein Theoretical pI:6
PDB File:1XS1
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Deoxycytidine triphosphate deaminase
MRLCDRDIEAWLDEGRLSINPRPPVERINGATVDVRLGNKFRTFRGHTAAFIDLSGPKDE
VSAALDRVMSDEIVLDEGEAFYLHPGELALAVTLESVTLPADLVGWLDGRSSLARLGLMV
HVTAHRIDPGWSGCIVLEFYNSGKLPLALRPGMLIGALSFEPLSGPAVRPYNRREDAKYR
NQQGAVASRIDKD
References
External Links:
ResourceLink
Uniprot ID:P28248
Uniprot Name:DCD_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85675048
PDB ID:1XS1
Ecogene ID:EG11418
Ecocyc:EG11418
ColiBase:b2065
Kegg Gene:b2065
EchoBASE ID:EB1389
CCDB:DCD_ECOLI
BacMap:16130005
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Itoh, T., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Kasai, H., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Seki, Y., Horiuchi, T., et, a. l. .. (1996). "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." DNA Res 3:379-392. Pubmed: 9097040
  • Wang, L., Weiss, B. (1992). "dcd (dCTP deaminase) gene of Escherichia coli: mapping, cloning, sequencing, and identification as a locus of suppressors of lethal dut (dUTPase) mutations." J Bacteriol 174:5647-5653. Pubmed: 1324907