Biotin synthesis protein BioC (P12999)

Identification
Name:Biotin synthesis protein BioC
Synonyms:Not Available
Gene Name:bioC
Enzyme Class:Not Available
Biological Properties
General Function:Involved in biotin biosynthetic process
Specific Function:BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
SMPDB Reactions:
1.0a malonyl-[acp]+1.0S-adenosyl-L-methionine → 1.0Thumb+1.0a malonyl-[acp] methyl ester
1.0a malonyl-[acp] + 1.0S-adenosyl-L-methionine → 1.0S-Adenosylhomocysteine + 1.0a malonyl-[acp] methyl ester
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0malonyl-CoA methyl ester
1.0S-Adenosylmethionine + 1.0Malonyl-CoA → 1.0S-Adenosylhomocysteine + 1.0malonyl-CoA methyl ester
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB01175Malonyl-CoAMetaboCard
ECMDB23166malonyl-CoA methyl esterMetaboCard
ECMDB00939S-AdenosylhomocysteineMetaboCard
ECMDB01185S-AdenosylmethionineMetaboCard
GO Classification:
Function
catalytic activity
methyltransferase activity
transferase activity
transferase activity, transferring one-carbon groups
Process
biotin biosynthetic process
biotin metabolic process
metabolic process
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
Gene Properties
Blattner:b0777
Gene OrientationClockwise
Centisome Percentage:17.47
Left Sequence End810745
Right Sequence End811500
Gene Sequence:
>756 bp
ATGGCAACGGTTAATAAACAAGCCATTGCAGCGGCATTTGGTCGGGCAGCCGCACACTAT
GAGCAACATGCAGATCTACAGCGCCAGAGTGCTGACGCCTTACTGGCAATGCTTCCACAG
CGTAAATACACCCACGTACTGGACGCGGGTTGTGGACCTGGCTGGATGAGCCGCCACTGG
CGGGAACGTCACGCGCAGGTGACGGCCTTAGATCTCTCGCCGCCAATGCTTGTTCAGGCA
CGCCAGAAGGATGCCGCAGACCATTATCTGGCGGGAGATATCGAATCCCTGCCGTTAGCG
ACTGCGACGTTCGATCTTGCATGGAGCAATCTCGCAGTGCAGTGGTGCGGTAATTTATCC
ACGGCACTCCGCGAGCTGTATCGGGTGGTGCGCCCCAAAGGCGTGGTCGCGTTTACCACG
CTGGTGCAGGGATCGTTACCCGAACTGCATCAGGCGTGGCAGGCGGTGGACGAGCGTCCG
CATGCTAATCGCTTTTTACCGCCAGATGAAATCGAACAGTCGCTGAACGGCGTGCATTAT
CAACATCATATTCAGCCCATCACGCTGTGGTTTGATGATGCGCTCAGTGCCATGCGTTCG
CTGAAAGGCATCGGTGCCACGCATCTTCATGAAGGGCGCGACCCGCGAATATTAACGCGT
TCGCAGTTGCAGCGATTGCAACTGGCCTGGCCGCAACAGCAGGGGCGATATCCTCTGACG
TATCATCTTTTTTTGGGAGTGATTGCTCGTGAGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:251
Protein Molecular Weight:28276
Protein Theoretical pI:8
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Biotin synthesis protein BioC
MATVNKQAIAAAFGRAAAHYEQHADLQRQSADALLAMLPQRKYTHVLDAGCGPGWMSRHW
RERHAQVTALDLSPPMLVQARQKDAADHYLAGDIESLPLATATFDLAWSNLAVQWCGNLS
TALRELYRVVRPKGVVAFTTLVQGSLPELHQAWQAVDERPHANRFLPPDEIEQSLNGVHY
QHHIQPITLWFDDALSAMRSLKGIGATHLHEGRDPRILTRSQLQRLQLAWPQQQGRYPLT
YHLFLGVIARE
References
External Links:
ResourceLink
Uniprot ID:P12999
Uniprot Name:BIOC_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674760
Ecogene ID:EG10119
Ecocyc:EG10119
ColiBase:b0777
Kegg Gene:b0777
EchoBASE ID:EB0117
CCDB:BIOC_ECOLI
BacMap:16128745
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Otsuka, A. J., Buoncristiani, M. R., Howard, P. K., Flamm, J., Johnson, C., Yamamoto, R., Uchida, K., Cook, C., Ruppert, J., Matsuzaki, J. (1988). "The Escherichia coli biotin biosynthetic enzyme sequences predicted from the nucleotide sequence of the bio operon." J Biol Chem 263:19577-19585. Pubmed: 3058702