Phosphoserine phosphatase (P0AGB0)

Identification
Name:Phosphoserine phosphatase
Synonyms:
  • PSP
  • PSPase
  • O-phosphoserine phosphohydrolase
Gene Name:serB
Enzyme Class:
Biological Properties
General Function:Involved in catalytic activity
Specific Function:O-phospho-L(or D)-serine + H(2)O = L(or D)- serine + phosphate
Cellular Location:Cytoplasmic
SMPDB Pathways:
  • Secondary Metabolites: cysteine biosynthesis from serine PW000977
  • cysteine biosynthesis PW000800
  • serine biosynthesis and metabolism PW000809
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Phosphoserine + 1.0Water ↔ 1.0L-Serine + 1.0Phosphate
ReactionCard
1.0Thumb+1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb+1.0Thumb
1.0Phosphoserine + 1.0O-Phospho-D-serine + 1.0Water ↔ 1.0L-Serine + 1.0D-Serine + 1.0Phosphate
ReactionCard
SMPDB Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0L-Serine+1.0Thumb
1.0DL-O-Phosphoserine + 1.0Water → 1.0Phosphate + 1.0L-Serine + 1.0L-Serine
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0O-Phospho-D-serine + 1.0Water → 1.0L-Serine + 1.0Inorganic phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB24073DL-O-PhosphoserineMetaboCard
ECMDB21380Inorganic phosphateMetaboCard
ECMDB00187L-SerineMetaboCard
ECMDB20276O-Phospho-D-serineMetaboCard
ECMDB01429PhosphateMetaboCard
ECMDB00272PhosphoserineMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on ester bonds
phosphatase activity
phosphoric ester hydrolase activity
phosphoserine phosphatase activity
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
L-serine biosynthetic process
L-serine metabolic process
metabolic process
serine family amino acid metabolic process
Gene Properties
Blattner:b4388
Gene OrientationClockwise
Centisome Percentage:99.64
Left Sequence End4622918
Right Sequence End4623886
Gene Sequence:
>969 bp
ATGGCTCAGCTTTCGTTACAACATATTCAAAAAATCTACGATAACCAGGTGCATGTGGTG
AAGGACTTCAACCTGGAAATTGCCGATAAAGAGTTCATCGTGTTTGTCGGCCCGTCGGGC
TGCGGTAAGTCGACCACCCTGCGCATGATTGCCGGGCTTGAGGAGATCAGCGGCGGCGAT
CTGTTGATCGACGGCAAACGAATGAATGACGTTCCAGCCAAAGCACGCAATATAGCGATG
GTGTTCCAGAACTACGCGTTGTATCCGCATATGACGGTTTACGACAACATGGCGTTTGGT
CTGAAGATGCAAAAAATCGCCAAAGAGGTGATTGATGAGCGGGTGAACTGGGCGGCGCAA
ATTCTCGGCCTGCGTGAGTACCTGAAACGTAAGCCGGGGGCGCTTTCCGGCGGGCAACGT
CAGCGAGTGGCGCTTGGGCGGGCGATTGTACGCGAAGCGGGCGTGTTTTTAATGGATGAA
CCGCTCTCTAACCTTGATGCCAAGCTGCGCGTGCAAATGCGCGCAGAGATCAGCAAGCTG
CATCAGAAACTGAACACCACCATGATCTACGTGACCCACGATCAGACCGAAGCGATGACC
ATGGCGACGCGGATTGTGATTATGAAAGACGGGATTGTTCAGCAAGTAGGTGCGCCGAAA
ACCGTTTATAACCAACCCGCGAATATGTTTGTTTCCGGATTTATTGGATCACCAGCGATG
AATTTTATTCGCGGCACGATCGATGGCGATAAATTCGTTACGGAAACGCTTAAATTAACC
ATTCCCGAAGAGAAATTAGCGGTTCTGAAAACACAGGAAAGTTTGCATAAGCCCATCGTG
ATGGGAATACGACCGGAAGATATTCATCCGGACGCGCAAGAGGAAAATAACATTTCCGCC
AAAATTAGCGTGGCAGAATTAACCGGTGCGGAATTTATGCTCTACACCACGGTTGGGGGC
ACGAGTTAG
Protein Properties
Pfam Domain Function:
Protein Residues:322
Protein Molecular Weight:35042
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Phosphoserine phosphatase
MPNITWCDLPEDVSLWPGLPLSLSGDEVMPLDYHAGRSGWLLYGRGLDKQRLTQYQSKLG
AAMVIVAAWCVEDYQVIRLAGSLTARATRLAHEAQLDVAPLGKIPHLRTPGLLVMDMDST
AIQIECIDEIAKLAGTGEMVAEVTERAMRGELDFTASLRSRVATLKGADANILQQVRENL
PLMPGLTQLVLKLETLGWKVAIASGGFTFFAEYLRDKLRLTAVVANELEIMDGKFTGNVI
GDIVDAQYKAKTLTRLAQEYEIPLAQTVAIGDGANDLPMIKAAGLGIAYHAKPKVNEKAE
VTIRHADLMGVFCILSGSLNQK
References
External Links:
ResourceLink
Uniprot ID:P0AGB0
Uniprot Name:SERB_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:1742155
Ecogene ID:EG10945
Ecocyc:EG10945
ColiBase:b4388
Kegg Gene:b4388
EchoBASE ID:EB0938
CCDB:SERB_ECOLI
BacMap:16132205
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Burland, V., Plunkett, G. 3rd, Sofia, H. J., Daniels, D. L., Blattner, F. R. (1995). "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Nucleic Acids Res 23:2105-2119. Pubmed: 7610040
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Neuwald, A. F., Stauffer, G. V. (1985). "DNA sequence and characterization of the Escherichia coli serB gene." Nucleic Acids Res 13:7025-7039. Pubmed: 2997734