Homoserine/homoserine lactone efflux protein (P0AG34)

Identification
Name:Homoserine/homoserine lactone efflux protein
Synonyms:Not Available
Gene Name:rhtB
Enzyme Class:Not Available
Biological Properties
General Function:Involved in amino acid transport
Specific Function:Conducts the efflux of homoserine and homoserine lactone
Cellular Location:Cell membrane; Multi-pass membrane protein (Potential)
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Transports:
Transport References:
  • Orth, J. D., Conrad, T. M., Na, J., Lerman, J. A., Nam, H., Feist, A. M., Palsson, B. O. (2011). "A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011." Mol Syst Biol 7:535. Pubmed: 21988831
Metabolites:
ECMDB IDNameView
ECMDB20567Homoserine lactoneMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB02251L-HomoserineMetaboCard
GO Classification:
Component
cell part
integral to membrane
intrinsic to membrane
membrane
membrane part
Process
amine transport
amino acid transport
establishment of localization
transport
Gene Properties
Blattner:b3824
Gene OrientationCounterclockwise
Centisome Percentage:86.35
Left Sequence End4006462
Right Sequence End4007082
Gene Sequence:
>621 bp
ATGAGCCAGTTTTTTTATATTCATCCTGATAACCCACAGCAACGTCTGATCAACCAGGCG
GTGGAGATCGTGCGTAAAGGCGGGGTGATTGTTTATCCAACTGATTCCGGCTATGCGCTC
GGCTGTAAAATTGAAGATAAAAACGCGATGGAGCGTATTTGTCGTATTCGCCAGCTGCCG
GACGGTCACAACTTTACCCTGATGTGTCGCGATCTTTCTGAACTCTCGACCTATTCATTT
GTTGATAACGTTGCGTTTCGTTTAATGAAAAACAACACGCCGGGCAACTATACCTTCATC
CTGAAGGGGACGAAGGAAGTGCCACGCCGTCTGTTGCAGGAAAAACGCAAAACCATCGGT
ATGCGTGTGCCTTCTAACCCTATCGCTCAGGCGTTACTTGAAGCATTGGGCGAACCGATG
CTTTCCACTTCGCTAATGCTGCCAGGCAGCGAATTTACCGAATCGGACCCGGAAGAAATT
AAAGATCGTCTGGAAAAACAGGTAGATTTGATTATTCACGGCGGCTATCTCGGGCAGAAA
CCGACAACGGTTATTGATCTTACCGATGATACGCCGGTCGTGGTGCGTGAAGGCGTAGGT
GATGTGAAGCCTTTCTTATAA
Protein Properties
Pfam Domain Function:
Protein Residues:206
Protein Molecular Weight:22427
Protein Theoretical pI:11
Signaling Regions:
  • None
Transmembrane Regions:
  • 5-25
  • 45-65
  • 68-88
  • 117-137
  • 148-168
  • 182-202
Protein Sequence:
>Homoserine/homoserine lactone efflux protein
MTLEWWFAYLLTSIILSLSPGSGAINTMTTSLNHGYRGAVASIAGLQTGLAIHIVLVGVG
LGTLFSRSVIAFEVLKWAGAAYLIWLGIQQWRAAGAIDLKSLASTQSRRHLFQRAVFVNL
TNPKSIVFLAALFPQFIMPQQPQLMQYIVLGVTTIVVDIIVMIGYATLAQRIALWIKGPK
QMKALNKIFGSLFMLVGALLASARHA
References
External Links:
ResourceLink
Uniprot ID:P0AG34
Uniprot Name:RHTB_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674890
Ecogene ID:EG11469
Ecocyc:EG11469
ColiBase:b3824
Kegg Gene:b3824
EchoBASE ID:EB1437
CCDB:RHTB_ECOLI
BacMap:49176422
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Daniels, D. L., Plunkett, G. 3rd, Burland, V., Blattner, F. R. (1992). "Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes." Science 257:771-778. Pubmed: 1379743
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Riley, M., Abe, T., Arnaud, M. B., Berlyn, M. K., Blattner, F. R., Chaudhuri, R. R., Glasner, J. D., Horiuchi, T., Keseler, I. M., Kosuge, T., Mori, H., Perna, N. T., Plunkett, G. 3rd, Rudd, K. E., Serres, M. H., Thomas, G. H., Thomson, N. R., Wishart, D., Wanner, B. L. (2006). "Escherichia coli K-12: a cooperatively developed annotation snapshot--2005." Nucleic Acids Res 34:1-9. Pubmed: 16397293
  • Zakataeva, N. P., Aleshin, V. V., Tokmakova, I. L., Troshin, P. V., Livshits, V. A. (1999). "The novel transmembrane Escherichia coli proteins involved in the amino acid efflux." FEBS Lett 452:228-232. Pubmed: 10386596