UTP--glucose-1-phosphate uridylyltransferase (P0AAB6)

Identification
Name:UTP--glucose-1-phosphate uridylyltransferase
Synonyms:
  • Alpha-D-glucosyl-1-phosphate uridylyltransferase
  • UDP-glucose pyrophosphorylase
  • UDPGP
  • Uridine diphosphoglucose pyrophosphorylase
Gene Name:galF
Enzyme Class:
Biological Properties
General Function:Involved in enzyme regulator activity
Specific Function:UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Glucose 1-phosphate + 1.0Hydrogen ion + 1.0Uridine triphosphate ↔ 1.0Pyrophosphate + 1.0UDP-Glucose
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Uridine triphosphate + 1.0Glucose 1-phosphate ↔ 1.0Pyrophosphate + 1.0UDP-Glucose
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Glucose 1-phosphate + 1.0Hydrogen ion + 1.0Uridine triphosphate ↔ 1.0Pyrophosphate + 1.0UDP-Glucose
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB01586Glucose 1-phosphateMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB04142PyrophosphateMetaboCard
ECMDB04171UDP-GlucoseMetaboCard
ECMDB00285Uridine triphosphateMetaboCard
GO Classification:
Function
catalytic activity
enzyme regulator activity
nucleotidyltransferase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
alcohol metabolic process
biosynthetic process
glucose metabolic process
hexose metabolic process
metabolic process
monosaccharide metabolic process
small molecule metabolic process
UDP-glucose metabolic process
Gene Properties
Blattner:b2042
Gene OrientationCounterclockwise
Centisome Percentage:45.51
Left Sequence End2111458
Right Sequence End2112351
Gene Sequence:
>894 bp
ATGAAAACACTGGTTGTGGCTCTTGGGGGCAACGCCTTACTCCAGCGCGGTGAGGCGCTG
ACGGCAGAAAATCAATATCGCAATATCGCCAGTGCTGTACCCGCGCTGGCACGCCTGGCC
CGTTCTTATCGGTTGGCGATTGTTCACGGCAACGGGCCGCAGGTGGGGCTGCTGGCATTG
CAGAATCTGGCGTGGAAAGAGGTAGAACCGTATCCGCTGGATGTGCTGGTTGCGGAAAGC
CAGGGGATGATTGGCTATATGCTGGCGCAGAGTTTGAGCGCACAGCCGCAGATGCCGCCC
GTGACGACGGTGCTGACGCGCATTGAGGTTTCGCCTGATGATCCGGCGTTTTTGCAGCCA
GAGAAATTTATTGGTCCGGTTTATCAGCCAGAAGAACAAGAGGCACTGGAAGCGGCTTAC
GGCTGGCAGATGAAACGTGATGGTAAATATTTGCGCCGGGTGGTGGCGTCTCCGCAACCG
CGTAAAATTCTCGACAGCGAAGCCATCGAGTTGTTGCTCAAAGAGGGGCATGTGGTGATT
TGCAGTGGCGGCGGCGGTGTGCCTGTGACGGATGACGGAGCAGGGAGTGAAGCAGTGATT
GATAAAGATCTCGCCGCTGCGTTGCTCGCCGAGCAGATTAATGCAGATGGACTGGTGATC
CTCACCGATGCTGATGCGGTATATGAAAACTGGGGAACGCCGCAGCAACGTGCCATTCGC
CATGCCACACCGGATGAGTTAGCGCCATTTGCCAAAGCCGATGGTTCGATGGGGCCGAAT
GTAACGGCGGTGAGTGGTTATGTCAGAAGCCGTGGTAAACCCGCGTGGATTGGGGCGTTA
TCGCGAATTGAAGAGACGCTGGCGGGCGAAGCGGGGACCTGTATTTCGCTGTAG
Protein Properties
Pfam Domain Function:
Protein Residues:297
Protein Molecular Weight:32829
Protein Theoretical pI:6
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>UTP--glucose-1-phosphate uridylyltransferase
MTNLKAVIPVAGLGMHMLPATKAIPKEMLPIVDKPMIQYIVDEIVAAGIKEILLVTHASK
NAVENHFDTSYELESLLEQRVKRQLLAEVQSICPPGVTIMNVRQGEPLGLGHSILCARPA
IGDNPFVVVLPDVVIDDASADPLRYNLAAMIARFNETGRSQVLAKRMPGDLSEYSVIQTK
EPLDREGKVSRIVEFIEKPDQPQTLDSDIMAVGRYVLSADIWPELERTQPGAWGRIQLTD
AIAELAKKQSVDAMLMTGDSYDCGKKMGYMQAFVKYGLRNLKEGAKFRKGIEKLLSE
References
External Links:
ResourceLink
Uniprot ID:P0AAB6
Uniprot Name:GALF_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674658
Ecogene ID:EG13578
Ecocyc:EG13578
ColiBase:b2042
Kegg Gene:b2042
EchoBASE ID:EB3348
CCDB:GALF_ECOLI
BacMap:16129982
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Itoh, T., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Kasai, H., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Seki, Y., Horiuchi, T., et, a. l. .. (1996). "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." DNA Res 3:379-392. Pubmed: 9097040
  • Marolda, C. L., Valvano, M. A. (1996). "The GalF protein of Escherichia coli is not a UDP-glucose pyrophosphorylase but interacts with the GalU protein possibly to regulate cellular levels of UDP-glucose." Mol Microbiol 22:827-840. Pubmed: 8971705