Uronate isomerase (P0A8G3)

Identification
Name:Uronate isomerase
Synonyms:
  • Glucuronate isomerase
  • Uronic isomerase
Gene Name:uxaC
Enzyme Class:
Biological Properties
General Function:Involved in glucuronate isomerase activity
Specific Function:D-glucuronate = D-fructuronate
Cellular Location:Not Available
SMPDB Pathways:
  • hexuronide and hexuronate degradation PW000834
KEGG Pathways:
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb
1.0D-Glucuronic acid ↔ 1.0D-Fructuronate
ReactionCard
1.0Thumb ↔ 1.0Thumb
1.0D-Galacturonate ↔ 1.05-Keto-D-gluconate
ReactionCard
SMPDB Reactions:
1.0Thumb → 1.0Thumb
1.0aldehydo-D-glucuronate → 1.0D-Fructuronate
ReactionCard
1.0Thumb → 1.0D-tagaturonate+1.0Thumb
1.0aldehydo-D-galacturonate → 1.0D-tagaturonate + 1.0D-Tagaturonate
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0Thumb
1.0D-Glucuronic acid ↔ 1.0D-Fructuronate
ReactionCard
1.0Thumb ↔ 1.0D-tagaturonate
1.0D-Galacturonate ↔ 1.0D-tagaturonate
ReactionCard
1.0Thumb → 1.0D-tagaturonate
1.0D-Galacturonate → 1.0D-tagaturonate
ReactionCard
Complex Reactions:
1.0Thumb → 1.0Thumb
1.0D-Glucuronic acid → 1.0D-Fructuronate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB117315-Keto-D-gluconateMetaboCard
ECMDB24230aldehydo-D-galacturonateMetaboCard
ECMDB24228aldehydo-D-glucuronateMetaboCard
ECMDB20138D-FructuronateMetaboCard
ECMDB20143D-GalacturonateMetaboCard
ECMDB04073D-Glucuronic acidMetaboCard
ECMDB23816D-TagaturonateMetaboCard
GO Classification:
Function
catalytic activity
glucuronate isomerase activity
intramolecular oxidoreductase activity
intramolecular oxidoreductase activity, interconverting aldoses and ketoses
isomerase activity
Process
carbohydrate catabolic process
carbohydrate metabolic process
glucuronate catabolic process
metabolic process
primary metabolic process
Gene Properties
Blattner:b3092
Gene OrientationCounterclockwise
Centisome Percentage:69.86
Left Sequence End3241351
Right Sequence End3242763
Gene Sequence:
>1413 bp
ATGAAAAAGACCAAAATTGTTTGCACCATCGGACCGAAAACCGAATCTGAAGAGATGTTA
GCTAAAATGCTGGACGCTGGCATGAACGTTATGCGTCTGAACTTCTCTCATGGTGACTAT
GCAGAACACGGTCAGCGCATTCAGAATCTGCGCAACGTGATGAGCAAAACTGGTAAAACC
GCCGCTATCCTGCTTGATACCAAAGGTCCGGAAATCCGCACCATGAAACTGGAAGGCGGT
AACGACGTTTCTCTGAAAGCTGGTCAGACCTTTACTTTCACCACTGATAAATCTGTTATC
GGCAACAGCGAAATGGTTGCGGTAACGTATGAAGGTTTCACTACTGACCTGTCTGTTGGC
AACACCGTACTGGTTGACGATGGTCTGATCGGTATGGAAGTTACCGCCATTGAAGGTAAC
AAAGTTATCTGTAAAGTGCTGAACAACGGTGACCTGGGCGAAAACAAAGGTGTGAACCTG
CCTGGCGTTTCCATTGCTCTGCCAGCACTGGCTGAAAAAGACAAACAGGACCTGATCTTT
GGTTGCGAACAAGGCGTAGACTTTGTTGCTGCTTCCTTTATTCGTAAGCGTTCTGACGTT
ATCGAAATCCGTGAGCACCTGAAAGCGCACGGCGGCGAAAACATCCACATCATCTCCAAA
ATCGAAAACCAGGAAGGCCTCAACAACTTCGACGAAATCCTCGAAGCCTCTGACGGCATC
ATGGTTGCGCGTGGCGACCTGGGTGTAGAAATCCCGGTAGAAGAAGTTATCTTCGCCCAG
AAGATGATGATCGAAAAATGTATCCGTGCACGTAAAGTCGTTATCACTGCGACCCAGATG
CTGGATTCCATGATCAAAAACCCACGCCCGACTCGCGCAGAAGCCGGTGACGTTGCAAAC
GCCATCCTCGACGGTACTGACGCAGTGATGCTGTCTGGTGAATCCGCAAAAGGTAAATAC
CCGCTGGAAGCGGTTTCTATCATGGCGACCATCTGCGAACGTACCGACCGCGTGATGAAC
AGCCGTCTCGAGTTCAACAATGACAACCGTAAACTGCGCATTACCGAAGCGGTATGCCGT
GGTGCCGTTGAAACTGCTGAAAAACTGGATGCTCCGCTGATCGTGGTTGCTACTCAGGGC
GGTAAATCTGCTCGCGCAGTACGTAAATACTTCCCGGATGCCACCATCCTGGCACTGACC
ACCAACGAAAAAACGGCTCATCAGTTGGTACTGAGCAAAGGCGTTGTGCCGCAGCTTGTT
AAAGAGATCACTTCTACTGATGATTTCTACCGTCTGGGTAAAGAACTGGCTCTGCAGAGC
GGTCTGGCACACAAAGGTGACGTTGTAGTTATGGTTTCTGGTGCACTGGTACCGAGCGGC
ACTACTAACACCGCATCTGTTCACGTCCTGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:470
Protein Molecular Weight:53987
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Uronate isomerase
MTPFMTEDFLLDTEFARRLYHDYAKDQPIFDYHCHLPPQQIAEDYRFKNLYDIWLKGDHY
KWRAMRTNGVAERLCTGDASDREKFDAWAATVPHTIGNPLYHWTHLELRRPFGITGKLLS
PSTADEIWNECNELLAQDNFSARGIMQQMNVKMVGTTDDPIDSLEHHAEIAKDGSFTIKV
LPSWRPDKAFNIEQATFNDYMAKLGEVSDTDIRRFADLQTALTKRLDHFAAHGCKVSDHA
LDVVMFAEANEAELDSILARRLAGETLSEHEVAQFKTAVLVFLGAEYARRGWVQQYHIGA
LRNNNLRQFKLLGPDVGFDSINDRPMAEELSKLLSKQNEENLLPKTILYCLNPRDNEVLG
TMIGNFQGEGMPGKMQFGSGWWFNDQKDGMERQMTQLAQLGLLSRFVGMLTDSRSFLSYT
RHEYFRRILCQMIGRWVEAGEAPADINLLGEMVKNICFNNARDYFAIELN
References
External Links:
ResourceLink
Uniprot ID:P0A8G3
Uniprot Name:UXAC_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85675072
Ecogene ID:EG12737
Ecocyc:EG12737
ColiBase:b3092
Kegg Gene:b3092
EchoBASE ID:EB2593
CCDB:UXAC_ECOLI
BacMap:16130987
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553