Transaldolase B (P0A870)

Identification
Name:Transaldolase B
Synonyms:Not Available
Gene Name:talB
Enzyme Class:
Biological Properties
General Function:Involved in catalytic activity
Specific Function:Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Cellular Location:Cytoplasm (Probable)
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Sedoheptulose 7-phosphate+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Sedoheptulose 7-phosphate + 1.0D-Glyceraldehyde 3-phosphate ↔ 1.0D-Erythrose 4-phosphate + 1.0beta-D-Fructose 6-phosphate
ReactionCard
SMPDB Reactions:
1.0D-Sedoheptulose 7-phosphate+1.0D-Glyceraldehyde 3-phosphate+1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0D-Sedoheptulose 7-phosphate + 1.0D-Glyceraldehyde 3-phosphate + 1.0D-Sedoheptulose 7-phosphate + 1.0D-Glyceraldehyde 3-phosphate ↔ 1.0beta-D-Fructose 6-phosphate + 1.0D-Erythrose 4-phosphate
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0D-Glyceraldehyde 3-phosphate + 1.0D-Sedoheptulose 7-phosphate ↔ 1.0D-Erythrose 4-phosphate + 1.0Fructose 6-phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB03971beta-D-Fructose 6-phosphateMetaboCard
ECMDB02649D-Erythrose 4-phosphateMetaboCard
ECMDB01112D-Glyceraldehyde 3-phosphateMetaboCard
ECMDB01068D-Sedoheptulose 7-phosphateMetaboCard
ECMDB00124Fructose 6-phosphateMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
catalytic activity
transaldolase activity
transferase activity
transferase activity, transferring aldehyde or ketonic groups
Process
alcohol metabolic process
carbohydrate metabolic process
glucose catabolic process
glucose metabolic process
hexose metabolic process
metabolic process
monosaccharide metabolic process
pentose-phosphate shunt
primary metabolic process
small molecule metabolic process
Gene Properties
Blattner:b0008
Gene OrientationClockwise
Centisome Percentage:0.18
Left Sequence End8238
Right Sequence End9191
Gene Sequence:
>954 bp
ATGACGGACAAATTGACCTCCCTTCGTCAGTACACCACCGTAGTGGCCGACACTGGGGAC
ATCGCGGCAATGAAGCTGTATCAACCGCAGGATGCCACAACCAACCCTTCTCTCATTCTT
AACGCAGCGCAGATTCCGGAATACCGTAAGTTGATTGATGATGCTGTCGCCTGGGCGAAA
CAGCAGAGCAACGATCGCGCGCAGCAGATCGTGGACGCGACCGACAAACTGGCAGTAAAT
ATTGGTCTGGAAATCCTGAAACTGGTTCCGGGCCGTATCTCAACTGAAGTTGATGCGCGT
CTTTCCTATGACACCGAAGCGTCAATTGCGAAAGCAAAACGCCTGATCAAACTCTACAAC
GATGCTGGTATTAGCAACGATCGTATTCTGATCAAACTGGCTTCTACCTGGCAGGGTATC
CGTGCTGCAGAACAGCTGGAAAAAGAAGGCATCAACTGTAACCTGACCCTGCTGTTCTCC
TTCGCTCAGGCTCGTGCTTGTGCGGAAGCGGGCGTGTTCCTGATCTCGCCGTTTGTTGGC
CGTATTCTTGACTGGTACAAAGCGAATACCGATAAGAAAGAGTACGCTCCGGCAGAAGAT
CCGGGCGTGGTTTCTGTATCTGAAATCTACCAGTACTACAAAGAGCACGGTTATGAAACC
GTGGTTATGGGCGCAAGCTTCCGTAACATCGGCGAAATTCTGGAACTGGCAGGCTGCGAC
CGTCTGACCATCGCACCGGCACTGCTGAAAGAGCTGGCGGAGAGCGAAGGGGCTATCGAA
CGTAAACTGTCTTACACCGGCGAAGTGAAAGCGCGTCCGGCGCGTATCACTGAGTCCGAG
TTCCTGTGGCAGCACAACCAGGATCCAATGGCAGTAGATAAACTGGCGGAAGGTATCCGT
AAGTTTGCTATTGACCAGGAAAAACTGGAAAAAATGATCGGCGATCTGCTGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:317
Protein Molecular Weight:35219
Protein Theoretical pI:5
PDB File:1ONR
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Transaldolase B
MTDKLTSLRQYTTVVADTGDIAAMKLYQPQDATTNPSLILNAAQIPEYRKLIDDAVAWAK
QQSNDRAQQIVDATDKLAVNIGLEILKLVPGRISTEVDARLSYDTEASIAKAKRLIKLYN
DAGISNDRILIKLASTWQGIRAAEQLEKEGINCNLTLLFSFAQARACAEAGVFLISPFVG
RILDWYKANTDKKEYAPAEDPGVVSVSEIYQYYKEHGYETVVMGASFRNIGEILELAGCD
RLTIAPALLKELAESEGAIERKLSYTGEVKARPARITESEFLWQHNQDPMAVDKLAEGIR
KFAIDQEKLEKMIGDLL
References
External Links:
ResourceLink
Uniprot ID:P0A870
Uniprot Name:TALB_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:21321899
PDB ID:1ONR
Ecogene ID:EG11556
Ecocyc:EG11556
ColiBase:b0008
Kegg Gene:b0008
EchoBASE ID:EB1517
CCDB:TALB_ECOLI
BacMap:16128002
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Jia, J., Huang, W., Schorken, U., Sahm, H., Sprenger, G. A., Lindqvist, Y., Schneider, G. (1996). "Crystal structure of transaldolase B from Escherichia coli suggests a circular permutation of the alpha/beta barrel within the class I aldolase family." Structure 4:715-724. Pubmed: 8805555
  • Jia, J., Schorken, U., Lindqvist, Y., Sprenger, G. A., Schneider, G. (1997). "Crystal structure of the reduced Schiff-base intermediate complex of transaldolase B from Escherichia coli: mechanistic implications for class I aldolases." Protein Sci 6:119-124. Pubmed: 9007983
  • Link, A. J., Robison, K., Church, G. M. (1997). "Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12." Electrophoresis 18:1259-1313. Pubmed: 9298646
  • Schorken, U., Thorell, S., Schurmann, M., Jia, J., Sprenger, G. A., Schneider, G. (2001). "Identification of catalytically important residues in the active site of Escherichia coli transaldolase." Eur J Biochem 268:2408-2415. Pubmed: 11298760
  • Sprenger, G. A., Schorken, U., Sprenger, G., Sahm, H. (1995). "Transaldolase B of Escherichia coli K-12: cloning of its gene, talB, and characterization of the enzyme from recombinant strains." J Bacteriol 177:5930-5936. Pubmed: 7592346
  • Yura, T., Mori, H., Nagai, H., Nagata, T., Ishihama, A., Fujita, N., Isono, K., Mizobuchi, K., Nakata, A. (1992). "Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region." Nucleic Acids Res 20:3305-3308. Pubmed: 1630901