Identification |
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Name: | DNA polymerase III subunit tau |
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Synonyms: | - DNA polymerase III subunit gamma
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Gene Name: | dnaX |
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Enzyme Class: | |
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Biological Properties |
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General Function: | Involved in nucleotide binding |
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Specific Function: | The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA |
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Cellular Location: | Cytoplasmic |
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SMPDB Pathways: | |
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KEGG Pathways: | |
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KEGG Reactions: | |
1.0 | + | 1.0DNA | ↔ | 1.0 | + | 1.0DNA |
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1.0 | + | 1.0DNA | ↔ | 1.0 | + | 1.0DNA |
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1.0 | + | 1.0DNA | ↔ | 1.0 | + | 1.0DNA |
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1.0 | + | 1.0DNA | ↔ | 1.0 | + | 1.0DNA |
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1.0Deoxynucleoside triphosphate | + | 1.0DNA | ↔ | 1.0 |
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Metabolites: | |
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GO Classification: | Component |
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DNA polymerase complex | DNA polymerase III complex | macromolecular complex | protein complex | Function |
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adenyl nucleotide binding | adenyl ribonucleotide binding | ATP binding | binding | catalytic activity | DNA binding | DNA polymerase activity | DNA-directed DNA polymerase activity | hydrolase activity | hydrolase activity, acting on acid anhydrides | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | nucleic acid binding | nucleoside binding | nucleoside-triphosphatase activity | nucleotide binding | nucleotidyltransferase activity | purine nucleoside binding | pyrophosphatase activity | transferase activity | transferase activity, transferring phosphorus-containing groups | Process |
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cellular macromolecule metabolic process | DNA metabolic process | DNA replication | macromolecule metabolic process | metabolic process |
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Gene Properties |
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Blattner: | b0470 |
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Gene Orientation | Clockwise |
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Centisome Percentage: | 10.59 |
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Left Sequence End | 491316 |
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Right Sequence End | 493247 |
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Gene Sequence: | >1932 bp
ATGAGTTATCAGGTCTTAGCCCGAAAATGGCGCCCACAAACCTTTGCTGACGTCGTCGGC
CAGGAACATGTGCTGACCGCACTGGCGAACGGCTTGTCGTTAGGGCGTATTCATCATGCT
TATCTTTTTTCCGGCACCCGTGGCGTCGGAAAAACCTCTATCGCCCGACTGCTGGCGAAG
GGGCTAAACTGCGAAACCGGCATTACCGCGACGCCGTGCGGCGTGTGCGATAACTGTCGT
GAAATCGAGCAGGGGCGCTTTGTCGATCTGATTGAAATCGACGCCGCCTCGCGCACCAAA
GTTGAAGATACCCGCGACCTGCTGGATAACGTCCAGTACGCTCCGGCGCGTGGTCGTTTC
AAAGTTTATCTGATCGACGAAGTGCATATGCTGTCGCGCCACAGCTTTAACGCACTGTTA
AAAACCCTTGAAGAGCCGCCGGAGCACGTTAAGTTTCTGCTGGCGACGACCGATCCACAG
AAATTGCCGGTGACGATTTTGTCACGCTGTCTGCAATTTCATCTCAAGGCGCTGGATGTC
GAGCAAATTCGCCATCAGCTTGAGCACATCCTCAACGAAGAACATATCGCTCACGAGCCG
CGGGCGCTGCAATTGCTGGCACGCGCCGCTGAAGGCAGCCTGCGAGATGCCTTAAGTCTG
ACCGACCAGGCGATTGCCAGCGGTGACGGCCAGGTTTCAACCCAGGCGGTCAGTGCGATG
CTGGGTACGCTTGACGACGATCAGGCGCTGTCGCTGGTTGAAGCGATGGTCGAGGCCAAC
GGCGAGCGCGTAATGGCGCTGATTAATGAAGCCGCTGCCCGTGGTATCGAGTGGGAAGCG
TTGCTGGTGGAAATGCTCGGCCTGTTGCATCGTATTGCGATGGTACAACTTTCGCCTGCT
GCACTTGGCAACGACATGGCCGCCATCGAGCTGCGGATGCGTGAACTGGCGCGCACCATA
CCGCCGACGGATATTCAGCTTTACTATCAGACGCTGTTGATTGGTCGCAAAGAATTACCG
TATGCGCCGGACCGTCGCATGGGCGTTGAGATGACGCTGCTGCGCGCGCTGGCATTCCAT
CCGCGTATGCCGCTGCCTGAGCCAGAAGTGCCACGACAGTCCTTTGCACCCGTCGCGCCA
ACGGCAGTAATGACGCCAACCCAGGTGCCGCCGCAACCGCAATCAGCGCCGCAGCAGGCA
CCGACTGTACCGCTCCCGGAAACCACCAGCCAGGTGCTGGCGGCGCGCCAGCAGTTGCAG
CGCGTGCAGGGAGCAACCAAAGCAAAAAAGAGTGAACCGGCAGCCGCTACCCGCGCGCGG
CCGGTGAATAACGCTGCGCTGGAAAGACTGGCTTCGGTCACCGATCGCGTTCAGGCGCGT
CCGGTGCCATCGGCGCTGGAAAAAGCGCCAGCCAAAAAAGAAGCGTATCGCTGGAAGGCG
ACCACTCCGGTGATGCAGCAAAAAGAAGTGGTCGCCACGCCGAAGGCGCTGAAAAAAGCG
CTGGAACATGAAAAAACGCCGGAACTGGCGGCGAAGCTAGCGGCAGAAGCCATTGAGCGC
GACCCGTGGGCGGCACAGGTGAGCCAACTTTCGCTACCAAAACTGGTCGAACAGGTGGCG
TTAAATGCCTGGAAAGAGGAGAGCGACAACGCAGTATGTCTGCATTTGCGCTCCTCTCAG
CGGCATTTGAACAACCGCGGTGCACAGCAAAAACTGGCTGAAGCGTTGAGCATGTTAAAA
GGTTCAACGGTTGAACTGACTATCGTTGAAGATGATAATCCCGCGGTGCGTACGCCGCTG
GAGTGGCGTCAGGCGATATACGAAGAAAAACTTGCGCAGGCGCGCGAGTCCATTATTGCG
GATAATAATATTCAGACCCTGCGTCGGTTCTTCGATGCGGAGCTGGATGAAGAAAGTATC
CGCCCCATTTGA |
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Protein Properties |
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Pfam Domain Function: | |
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Protein Residues: | 643 |
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Protein Molecular Weight: | 71137 |
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Protein Theoretical pI: | 7 |
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PDB File: | 1XXH |
Signaling Regions: | |
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Transmembrane Regions: | |
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Protein Sequence: | >DNA polymerase III subunit tau
MSYQVLARKWRPQTFADVVGQEHVLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAK
GLNCETGITATPCGVCDNCREIEQGRFVDLIEIDAASRTKVEDTRDLLDNVQYAPARGRF
KVYLIDEVHMLSRHSFNALLKTLEEPPEHVKFLLATTDPQKLPVTILSRCLQFHLKALDV
EQIRHQLEHILNEEHIAHEPRALQLLARAAEGSLRDALSLTDQAIASGDGQVSTQAVSAM
LGTLDDDQALSLVEAMVEANGERVMALINEAAARGIEWEALLVEMLGLLHRIAMVQLSPA
ALGNDMAAIELRMRELARTIPPTDIQLYYQTLLIGRKELPYAPDRRMGVEMTLLRALAFH
PRMPLPEPEVPRQSFAPVAPTAVMTPTQVPPQPQSAPQQAPTVPLPETTSQVLAARQQLQ
RVQGATKAKKSEPAAATRARPVNNAALERLASVTDRVQARPVPSALEKAPAKKEAYRWKA
TTPVMQQKEVVATPKALKKALEHEKTPELAAKLAAEAIERDPWAAQVSQLSLPKLVEQVA
LNAWKEESDNAVCLHLRSSQRHLNNRGAQQKLAEALSMLKGSTVELTIVEDDNPAVRTPL
EWRQAIYEEKLAQARESIIADNNIQTLRRFFDAELDEESIRPI |
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References |
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External Links: | |
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General Reference: | - Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Blinkowa, A. L., Walker, J. R. (1990). "Programmed ribosomal frameshifting generates the Escherichia coli DNA polymerase III gamma subunit from within the tau subunit reading frame." Nucleic Acids Res 18:1725-1729. Pubmed: 2186364
- Flower, A. M., McHenry, C. S. (1986). "The adjacent dnaZ and dnaX genes of Escherichia coli are contained within one continuous open reading frame." Nucleic Acids Res 14:8091-8101. Pubmed: 3534795
- Flower, A. M., McHenry, C. S. (1990). "The gamma subunit of DNA polymerase III holoenzyme of Escherichia coli is produced by ribosomal frameshifting." Proc Natl Acad Sci U S A 87:3713-3717. Pubmed: 2187190
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
- O'Donnell, M. (1992). "Accessory protein function in the DNA polymerase III holoenzyme from E. coli." Bioessays 14:105-111. Pubmed: 1575709
- Tsuchihashi, Z., Kornberg, A. (1990). "Translational frameshifting generates the gamma subunit of DNA polymerase III holoenzyme." Proc Natl Acad Sci U S A 87:2516-2520. Pubmed: 2181440
- Yin, K. C., Blinkowa, A., Walker, J. R. (1986). "Nucleotide sequence of the Escherichia coli replication gene dnaZX." Nucleic Acids Res 14:6541-6549. Pubmed: 3018672
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