CDP-diacylglycerol pyrophosphatase (P06282)

Identification
Name:CDP-diacylglycerol pyrophosphatase
Synonyms:
  • CDP-diacylglycerol phosphatidylhydrolase
  • CDP-diglyceride hydrolase
Gene Name:cdh
Enzyme Class:
Biological Properties
General Function:Involved in CDP-diacylglycerol diphosphatase activity
Specific Function:CDP-diacylglycerol + H(2)O = CMP + phosphatidate
Cellular Location:Cell inner membrane; Single-pass membrane protein
SMPDB Pathways:Not Available
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 2.0Thumb+1.0Thumb+1.0Thumb
1.0Water + 1.0UDP-2,3-Bis(3-hydroxytetradecanoyl)glucosamine ↔ 2.0Hydrogen ion + 1.02,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + 1.0Uridine 5'-monophosphate
ReactionCard
1.0CDP-diacylglycerol+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0CDP-diacylglycerol + 1.0Water ↔ 1.0Cytidine monophosphate + 1.0PA(16:0/16:0)
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb ↔ 2.0Thumb+1.0Thumb+1.0Thumb
1.0Water + 1.0UDP-2,3-Bis(3-hydroxytetradecanoyl)glucosamine ↔ 2.0Hydrogen ion + 1.02,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + 1.0Uridine 5'-monophosphate
ReactionCard
1.0a CDP-diacylglycerol+1.0Thumb ↔ 1.0Thumb+1.0Thumb+1.0Thumb
1.0a CDP-diacylglycerol + 1.0Water ↔ 1.0PA(16:0/16:0) + 1.0Cytidine monophosphate + 1.0Hydrogen ion
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb+1.0Thumb
1.0Water + 1.0UDP-2,3-Bis(3-hydroxytetradecanoyl)glucosamine → 1.0Hydrogen ion + 1.02,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + 1.0Uridine 5'-monophosphate
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+2.0Thumb+1.0Thumb
1.0CDP-1,2-didodecanoylglycerol + 1.0Water → 1.0Cytidine monophosphate + 2.0Hydrogen ion + 1.0PA(16:0/16:0)
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+2.0Thumb+1.0Thumb
1.0CDP-1,2-dihexadec-9-enoylglycerol + 1.0Water → 1.0Cytidine monophosphate + 2.0Hydrogen ion + 1.0PA(16:0/16:0)
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+2.0Thumb+1.0Thumb
1.0CDP-1,2-dihexadecanoylglycerol + 1.0Water → 1.0Cytidine monophosphate + 2.0Hydrogen ion + 1.0PA(16:0/16:0)
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+2.0Thumb+1.0Thumb
1.0CDP-1,2-dioctadec-11-enoylglycerol + 1.0Water → 1.0Cytidine monophosphate + 2.0Hydrogen ion + 1.0PA(16:0/16:0)
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+2.0Thumb+1.0Thumb
1.0CDP-1,2-Dioctadecanoylglycerol + 1.0Water → 1.0Cytidine monophosphate + 2.0Hydrogen ion + 1.0PA(16:0/16:0)
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+2.0Thumb+1.0Thumb
1.0CDP-1,2-ditetradec-7-enoylglycerol + 1.0Water → 1.0Cytidine monophosphate + 2.0Hydrogen ion + 1.0PA(16:0/16:0)
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+2.0Thumb+1.0Thumb
1.0CDP-1,2-ditetradecanoylglycerol + 1.0Water → 1.0Cytidine monophosphate + 2.0Hydrogen ion + 1.0PA(16:0/16:0)
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB200542,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphateMetaboCard
ECMDB21187CDP-1,2-didodecanoylglycerolMetaboCard
ECMDB21188CDP-1,2-dihexadec-9-enoylglycerolMetaboCard
ECMDB21189CDP-1,2-dihexadecanoylglycerolMetaboCard
ECMDB21190CDP-1,2-dioctadec-11-enoylglycerolMetaboCard
ECMDB21191CDP-1,2-DioctadecanoylglycerolMetaboCard
ECMDB21192CDP-1,2-ditetradec-7-enoylglycerolMetaboCard
ECMDB21193CDP-1,2-ditetradecanoylglycerolMetaboCard
ECMDB00095Cytidine monophosphateMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB00674PA(16:0/16:0)MetaboCard
ECMDB20201UDP-2,3-Bis(3-hydroxytetradecanoyl)glucosamineMetaboCard
ECMDB00288Uridine 5'-monophosphateMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Component
cell part
membrane
Function
catalytic activity
CDP-diacylglycerol diphosphatase activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
Process
metabolic process
organophosphate metabolic process
phospholipid biosynthetic process
phospholipid metabolic process
Gene Properties
Blattner:b3918
Gene OrientationClockwise
Centisome Percentage:88.54
Left Sequence End4107953
Right Sequence End4108708
Gene Sequence:
>756 bp
ATGGCAACGGTTAATAAACAAGCCATTGCAGCGGCATTTGGTCGGGCAGCCGCACACTAT
GAGCAACATGCAGATCTACAGCGCCAGAGTGCTGACGCCTTACTGGCAATGCTTCCACAG
CGTAAATACACCCACGTACTGGACGCGGGTTGTGGACCTGGCTGGATGAGCCGCCACTGG
CGGGAACGTCACGCGCAGGTGACGGCCTTAGATCTCTCGCCGCCAATGCTTGTTCAGGCA
CGCCAGAAGGATGCCGCAGACCATTATCTGGCGGGAGATATCGAATCCCTGCCGTTAGCG
ACTGCGACGTTCGATCTTGCATGGAGCAATCTCGCAGTGCAGTGGTGCGGTAATTTATCC
ACGGCACTCCGCGAGCTGTATCGGGTGGTGCGCCCCAAAGGCGTGGTCGCGTTTACCACG
CTGGTGCAGGGATCGTTACCCGAACTGCATCAGGCGTGGCAGGCGGTGGACGAGCGTCCG
CATGCTAATCGCTTTTTACCGCCAGATGAAATCGAACAGTCGCTGAACGGCGTGCATTAT
CAACATCATATTCAGCCCATCACGCTGTGGTTTGATGATGCGCTCAGTGCCATGCGTTCG
CTGAAAGGCATCGGTGCCACGCATCTTCATGAAGGGCGCGACCCGCGAATATTAACGCGT
TCGCAGTTGCAGCGATTGCAACTGGCCTGGCCGCAACAGCAGGGGCGATATCCTCTGACG
TATCATCTTTTTTTGGGAGTGATTGCTCGTGAGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:251
Protein Molecular Weight:28451
Protein Theoretical pI:9
Signaling Regions:
  • None
Transmembrane Regions:
  • 4-24
Protein Sequence:
>CDP-diacylglycerol pyrophosphatase
MKKAGLLFLVMIVIAVVAAGIGYWKLTGEESDTLRKIVLEECLPNQQQNQNPSPCAEVKP
NAGYVVLKDLNGPLQYLLMPTYRINGTESPLLTDPSTPNFFWLAWQARDFMSKKYGQPVP
DRAVSLAINSRTGRTQNHFHIHISCIRPDVRKQLDNNLANISSRWLPLPGGLRGHEYLAR
RVTESELVQRSPFMMLAEEVPEAREHMGRYGLAMVRQSDNSFVLLATQRNLLTLNRASAE
EIQDHQCEILR
References
External Links:
ResourceLink
Uniprot ID:P06282
Uniprot Name:CDH_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674760
Ecogene ID:EG10138
Ecocyc:EG10138
ColiBase:b3918
Kegg Gene:b3918
EchoBASE ID:EB0136
CCDB:CDH_ECOLI
BacMap:16131756
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Hellinga, H. W., Evans, P. R. (1985). "Nucleotide sequence and high-level expression of the major Escherichia coli phosphofructokinase." Eur J Biochem 149:363-373. Pubmed: 3158524
  • Icho, T., Bulawa, C. E., Raetz, C. R. (1985). "Molecular cloning and sequencing of the gene for CDP-diglyceride hydrolase of Escherichia coli." J Biol Chem 260:12092-12098. Pubmed: 2995360
  • Plunkett, G. 3rd, Burland, V., Daniels, D. L., Blattner, F. R. (1993). "Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes." Nucleic Acids Res 21:3391-3398. Pubmed: 8346018