Description | PA(16:0/16:0) is a phosphatidic acid. It is a glycerophospholipid in which a phosphate moiety occupies a glycerol substitution site. As is the case with diacylglycerols, phosphatidic acids can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PA(16:0/16:0), in particular, consists of one chain of palmitic acid at the C-1 position and one chain of palmitic acid at the C-2 position. Phosphatidic acids are quite rare but are extremely important as intermediates in the biosynthesis of triacylglycerols and phospholipids. Phospholipase Ds (PLDs), which catalyze the conversion of glycerolphospholipids, particularly phosphatidylcholine, to PAs and the conversion of N-arachidonoyl-phosphatidylethanolamine (NAPE) to anandamide and PAs are activated by several inflammatory mediators including bradykinin, ATP and glutamate. Circumstantial evidence that PAs are converted to DAGs. (PMID: 12618218, 16185776). |
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Synonyms: | - 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphate
- 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
- 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
- 1,2-Dihexadecanoyl-rac-phosphatidate
- 1,2-Dihexadecanoyl-rac-phosphatidic acid
- 1,2-Dipalmitoyl-3-sn-phosphatidate
- 1,2-Dipalmitoyl-3-sn-phosphatidic acid
- 1,2-Dipalmitoyl-sn-glycerol 3-phosphate
- 1,2-Dipalmitoyl-sn-glycerol 3-phosphoric acid
- 1,2-Dipalmitoyl-sn-glycerol-3-phosphate
- 1,2-Dipalmitoyl-sn-glycerol-3-phosphorate
- 1,2-Dipalmitoyl-sn-glycerol-3-phosphoric acid
- A 1,2-diacylglycerol-3-phosphate
- a 1,2-Diacylglycerol-3-phosphoric acid
- A 3-sn-phosphatidate
- a 3-sn-Phosphatidate
- a 3-sn-Phosphatidic acid
- A diacyl-glycerol-3p
- A diacyl-glycerol-p
- A diacylglycerol-3-phosphate
- a Diacylglycerol-3-phosphoric acid
- A phosphatidate
- A phosphatidic acid
- A phosphatidylglycerol
- An L-phosphatidate
- An L-phosphatidic acid
- DGP
- Diacylglycerol phosphate
- Diacylglycerol phosphoric acid
- Dipalmitoyl phosphatidate
- Dipalmitoyl-L-a-phosphatidate
- Dipalmitoyl-L-a-phosphatidic acid
- Dipalmitoyl-L-alpha-phosphatidate
- Dipalmitoyl-L-alpha-phosphatidic acid
- Dipalmitoyl-L-α-phosphatidate
- Dipalmitoyl-L-α-phosphatidic acid
- Dipalmitoylphosphatidate
- Dipalmitoylphosphatidic acid
- L-a-Dipalmitoyl-phosphatidate
- L-a-Dipalmitoyl-phosphatidic acid
- L-a-Dipalmitoylphosphatidate
- L-a-Dipalmitoylphosphatidic acid
- L-alpha-Dipalmitoyl-phosphatidate
- L-alpha-Dipalmitoyl-phosphatidic acid
- L-alpha-Dipalmitoylphosphatidate
- L-alpha-Dipalmitoylphosphatidic acid
- L-α-Dipalmitoyl-phosphatidate
- L-α-Dipalmitoyl-phosphatidic acid
- L-α-Dipalmitoylphosphatidate
- L-α-Dipalmitoylphosphatidic acid
- PA(32:0)
- Phosphatidate(16:0/16:0)
- Phosphatidate(32:0)
- Phosphatidic acid(16:0/16:0)
- Phosphatidic acid(32:0)
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References: | - Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114. Pubmed: 22080510
- Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. Pubmed: 21097882
- Niedernberg, A., Tunaru, S., Blaukat, A., Ardati, A., Kostenis, E. (2003). "Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63." Cell Signal 15:435-446. Pubmed: 12618218
- Park KA, Vasko MR: Lipid mediators of sensitivity in sensory neurons. Trends Pharmacol Sci. 2005 Nov;26(11):571-7. Epub 2005 Sep 26. Pubmed: 16185776
- Yurtsever D. (2007). Fatty acid methyl ester profiling of Enterococcus and Esherichia coli for microbial source tracking. M.sc. Thesis. Villanova University: U.S.A
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