Para-aminobenzoate synthase glutamine amidotransferase component II (P00903)

Identification
Name:Para-aminobenzoate synthase glutamine amidotransferase component II
Synonyms:
  • ADC synthase
Gene Name:pabA
Enzyme Class:
Biological Properties
General Function:Involved in metabolic process
Specific Function:Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Chorismate + 1.0L-Glutamine ↔ 1.04-Amino-4-deoxychorismate + 1.0L-Glutamate
ReactionCard
SMPDB Reactions:
1.0Thumb+1.0Thumb → 1.0L-Glutamic acid+1.04-amino-4-deoxychorismate+1.0Thumb+1.0Thumb
1.0Chorismate + 1.0L-Glutamine → 1.0L-Glutamic acid + 1.04-amino-4-deoxychorismate + 1.0L-Glutamate + 1.04-Amino-4-deoxychorismate
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Chorismate + 1.0L-Glutamine ↔ 1.04-Amino-4-deoxychorismate + 1.0L-Glutamate
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0Chorismate + 1.0L-Glutamine → 1.04-Amino-4-deoxychorismate + 1.0L-Glutamate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB200854-Amino-4-deoxychorismateMetaboCard
ECMDB12199ChorismateMetaboCard
ECMDB00148L-GlutamateMetaboCard
ECMDB00641L-GlutamineMetaboCard
GO Classification:
Function
anthranilate synthase activity
carbon-carbon lyase activity
catalytic activity
lyase activity
oxo-acid-lyase activity
Process
biosynthetic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
glutamine family amino acid metabolic process
glutamine metabolic process
metabolic process
Gene Properties
Blattner:b3360
Gene OrientationCounterclockwise
Centisome Percentage:75.18
Left Sequence End3488288
Right Sequence End3488851
Gene Sequence:
>564 bp
ATGTCCTTGATTAACACCAAAATTAAACCTTTTAAAAACCAGGCATTCAAAAACGGCGAA
TTCATCGAAATCACCGAAAAAGATACCGAAGGCCGCTGGAGCGTCTTCTTCTTCTACCCG
GCTGACTTTACTTTCGTATGCCCGACCGAACTGGGTGACGTTGCTGACCACTACGAAGAA
CTGCAGAAACTGGGCGTAGACGTATACGCAGTATCTACCGATACTCACTTCACCCACAAA
GCATGGCACAGCAGCTCTGAAACCATCGCTAAAATCAAATATGCGATGATCGGCGACCCG
ACTGGCGCCCTGACCCGTAACTTCGACAACATGCGTGAAGATGAAGGTCTGGCTGACCGT
GCGACCTTCGTTGTTGACCCGCAGGGTATCATCCAGGCAATCGAAGTTACCGCTGAAGGC
ATTGGCCGTGACGCGTCTGACCTGCTGCGTAAAATCAAAGCAGCACAGTACGTAGCTTCT
CACCCAGGTGAAGTTTGCCCGGCTAAATGGAAAGAAGGTGAAGCAACTCTGGCTCCGTCT
CTGGACCTGGTTGGTAAAATCTAA
Protein Properties
Pfam Domain Function:
Protein Residues:187
Protein Molecular Weight:20772
Protein Theoretical pI:7
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Para-aminobenzoate synthase glutamine amidotransferase component II
MILLIDNYDSFTWNLYQYFCELGADVLVKRNDALTLADIDALKPQKIVISPGPCTPDEAG
ISLDVIRHYAGRLPILGVCLGHQAMAQAFGGKVVRAAKVMHGKTSPITHNGEGVFRGLAN
PLTVTRYHSLVVEPDSLPACFDVTAWSETREIMGIRHRQWDLEGVQFHPESILSEQGHQL
LANFLHR
References
External Links:
ResourceLink
Uniprot ID:P00903
Uniprot Name:PABA_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:4062222
Ecogene ID:EG10682
Ecocyc:EG10682
ColiBase:b3360
Kegg Gene:b3360
EchoBASE ID:EB0676
CCDB:PABA_ECOLI
BacMap:16131239
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Kaplan, J. B., Nichols, B. P. (1983). "Nucleotide sequence of Escherichia coli pabA and its evolutionary relationship to trp(G)D." J Mol Biol 168:451-468. Pubmed: 6350604
  • Kawamukai, M., Matsuda, H., Fujii, W., Utsumi, R., Komano, T. (1989). "Nucleotide sequences of fic and fic-1 genes involved in cell filamentation induced by cyclic AMP in Escherichia coli." J Bacteriol 171:4525-4529. Pubmed: 2546924
  • Roux, B., Walsh, C. T. (1993). "p-Aminobenzoate synthesis in Escherichia coli: mutational analysis of three conserved amino acid residues of the amidotransferase PabA." Biochemistry 32:3763-3768. Pubmed: 8096767
  • Tran, P. V., Bannor, T. A., Doktor, S. Z., Nichols, B. P. (1990). "Chromosomal organization and expression of Escherichia coli pabA." J Bacteriol 172:397-410. Pubmed: 2403545