| Identification |
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| Name: | Multidrug resistance-like ATP-binding protein mdlA |
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| Synonyms: | Not Available |
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| Gene Name: | mdlA |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | Defense mechanisms |
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| Specific Function: | ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out) |
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| Cellular Location: | Cell inner membrane; Multi-pass membrane protein |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Complex Reactions: | |
1.0 | + | 1.0 | + | 1.0xenobiotic(In) | → | 1.0 | + | 1.0 | + | 1.0xenobiotic(Out) |
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| Metabolites: | |
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| GO Classification: | | Component |
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| cell part | | integral to membrane | | intrinsic to membrane | | membrane part | | Function |
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| active transmembrane transporter activity | | adenyl nucleotide binding | | adenyl ribonucleotide binding | | ATP binding | | ATPase activity | | ATPase activity, coupled to transmembrane movement of substances | | binding | | catalytic activity | | hydrolase activity | | hydrolase activity, acting on acid anhydrides | | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | | nucleoside binding | | nucleoside-triphosphatase activity | | nucleotide binding | | P-P-bond-hydrolysis-driven transmembrane transporter activity | | primary active transmembrane transporter activity | | purine nucleoside binding | | pyrophosphatase activity | | transmembrane transporter activity | | transporter activity | | Process |
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| establishment of localization | | transmembrane transport | | transport |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >1773 bp
GTGCGATTATTTGCTCAATTAAGCTGGTATTTCCGTCGGGAATGGCGTCGCTATCTCGGG
GCTGTCGCCTTGCTTGTCATTATCGCGATGCTGCAACTGGTTCCGCCAAAAGTGGTTGGT
ATTGTTGTCGATGGCGTGACAGAACAACACTTTACTACCGGGCAGATCCTGATGTGGATC
GCCACCATGGTGCTGATTGCCGTTGTGGTTTATCTCCTGCGTTACGTCTGGCGGGTATTG
CTGTTTGGTGCGTCTTATCAACTGGCTGTTGAACTGCGTGAAGATTATTACCGTCAGCTA
AGCCGGCAGCATCCTGAGTTTTACCTGCGTCATCGCACCGGTGACCTCATGGCTCGTGCG
ACCAATGACGTCGATCGCGTCGTGTTTGCCGCCGGAGAAGGGGTGCTGACGCTGGTGGAT
TCACTGGTGATGGGCTGCGCTGTGTTGATTATGATGTCTACGCAAATTAGCTGGCAGTTG
ACCTTATTTTCCCTGTTGCCGATGCCAGTGATGGCGATCATGATTAAGCGCAACGGCGAT
GCTTTGCATGAACGCTTTAAGCTGGCACAGGCGGCGTTTTCCAGTCTTAATGACCGCACC
CAGGAAAGCCTCACCAGTATCCGCATGATCAAAGCCTTTGGTCTGGAAGATCGCCAGTCG
GCGTTATTTGCCGCGGATGCCGAAGATACCGGCAAAAAAAACATGCGGGTGGCGCGTATT
GATGCTCGTTTCGACCCGACCATCTATATCGCGATTGGTATGGCGAACTTGCTGGCGATT
GGCGGCGGTAGTTGGATGGTGGTGCAGGGCAGTTTAACGCTGGGCCAGCTCACCAGTTTT
ATGATGTATTTAGGTCTGATGATTTGGCCAATGCTGGCGCTGGCATGGATGTTTAACATT
GTGGAACGTGGTAGTGCTGCGTACAGCCGTATTCGCGCGATGCTGGCGGAAGCGCCGGTG
GTGAACGATGGTAGCGAACCCGTGCCGGAAGGGCGTGGCGAACTGGATGTAAATATTCAC
CAGTTCACGTATCCGCAGACTGACCATCCTGCGCTGGAAAACGTCAATTTCGCCCTGAAA
CCCGGTCAGATGCTGGGTATCTGCGGGCCGACTGGTTCCGGCAAAAGTACCCTGTTGTCG
CTCATTCAGCGTCATTTCGACGTCAGCGAGGGGGATATTCGCTTTCATGATATTCCTCTG
ACGAAGTTACAACTCGATAGCTGGCGTAGCCGCCTGGCGGTAGTTAGCCAGACGCCATTC
CTTTTTTCTGACACTGTGGCGAATAACATCGCGCTGGGTTGCCCGAATGCCACCCAGCAA
GAGATTGAGCATGTCGCGCGGTTAGCCAGCGTACATGACGATATTTTGCGTCTACCGCAA
GGTTACGATACAGAGGTGGGCGAGCGCGGTGTGATGCTTTCCGGCGGGCAAAAACAGCGT
ATCTCCATTGCTCGTGCGTTATTAGTCAACGCGGAAATCCTCATCCTTGATGATGCGCTT
TCGGCGGTGGACGGACGCACTGAGCACCAGATCCTGCATAACCTGCGTCAGTGGGGGCAG
GGAAGAACGGTAATCATCAGTGCCCATCGCCTTTCTGCACTGACGGAAGCCAGTGAAATT
ATTGTGATGCAGCACGGACATATCGCCCAGCGTGGCAATCATGATGTGCTGGCACAACAA
AGCGGCTGGTATCGCGATATGTATCGCTATCAACAACTGGAGGCGGCGCTCGACGACGCT
CCGGAAAATCGCGAGGAGGCCGTCGATGCGTAG |
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| Protein Properties |
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| Pfam Domain Function: | |
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| Protein Residues: | 590 |
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| Protein Molecular Weight: | 66017 |
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| Protein Theoretical pI: | 7 |
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| Signaling Regions: | |
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| Transmembrane Regions: | - 23-43
- 53-73
- 134-154
- 155-175
- 248-268
- 280-300
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| Protein Sequence: | >Multidrug resistance-like ATP-binding protein mdlA
MRLFAQLSWYFRREWRRYLGAVALLVIIAMLQLVPPKVVGIVVDGVTEQHFTTGQILMWI
ATMVLIAVVVYLLRYVWRVLLFGASYQLAVELREDYYRQLSRQHPEFYLRHRTGDLMARA
TNDVDRVVFAAGEGVLTLVDSLVMGCAVLIMMSTQISWQLTLFSLLPMPVMAIMIKRNGD
ALHERFKLAQAAFSSLNDRTQESLTSIRMIKAFGLEDRQSALFAADAEDTGKKNMRVARI
DARFDPTIYIAIGMANLLAIGGGSWMVVQGSLTLGQLTSFMMYLGLMIWPMLALAWMFNI
VERGSAAYSRIRAMLAEAPVVNDGSEPVPEGRGELDVNIHQFTYPQTDHPALENVNFALK
PGQMLGICGPTGSGKSTLLSLIQRHFDVSEGDIRFHDIPLTKLQLDSWRSRLAVVSQTPF
LFSDTVANNIALGCPNATQQEIEHVARLASVHDDILRLPQGYDTEVGERGVMLSGGQKQR
ISIARALLVNAEILILDDALSAVDGRTEHQILHNLRQWGQGRTVIISAHRLSALTEASEI
IVMQHGHIAQRGNHDVLAQQSGWYRDMYRYQQLEAALDDAPENREEAVDA |
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| References |
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| External Links: | |
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| General Reference: | - Allikmets, R., Gerrard, B., Court, D., Dean, M. (1993). "Cloning and organization of the abc and mdl genes of Escherichia coli: relationship to eukaryotic multidrug resistance." Gene 136:231-236. Pubmed: 7904973
- Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
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