ECMDB

Identification

Name:

Acetate CoA-transferase subunit beta

Synonyms:

Acetyl-CoA:acetoacetate-CoA transferase subunit beta

Gene Name:

atoA

Enzyme Class:

2.8.3.8

Biological Properties

General Function:

Involved in CoA-transferase activity

Specific Function:

Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA

Cellular Location:

Not Available

SMPDB Pathways:

Acetate metabolism PW002090
Aminobenzoate Degradation PW000757
Propanoate metabolism PW000940

KEGG Pathways:

1,4-Dichlorobenzene degradation ec00627
Benzoate degradation via CoA ligation ec00632
Butanoate metabolism ec00650
Lysine degradation ec00310
Metabolic pathways eco01100
Microbial metabolism in diverse environments ec01120
Propanoate metabolism ec00640

KEGG Reactions:

1.0

→

1.0

1.0Acetoacetic acid + 1.0Acetyl-CoA → 1.0Acetoacetyl-CoA + 1.0Acetic acid
ReactionCard

1.0Butanoyl-CoA

1.0

↔

1.0

1.0Butanoyl-CoA + 1.0Acetic acid ↔ 1.0Butyric acid + 1.0Acetyl-CoA
ReactionCard

1.0

↔

1.0

1.0Acetoacetyl-CoA + 1.0Acetic acid ↔ 1.0Acetoacetic acid + 1.0Acetyl-CoA
ReactionCard

1.0

↔

1.0

1.03-Hydroxy-5-oxohexanoate + 1.0Acetyl-CoA ↔ 1.03-Hydroxy-5-oxohexanoyl-CoA + 1.0Acetic acid
ReactionCard

1.0Acyl-CoA

1.0

↔

1.0Fatty acid anion

1.0

1.0Acyl-CoA + 1.0Acetic acid ↔ 1.0Fatty acid anion + 1.0Acetyl-CoA
ReactionCard

SMPDB Reactions:

1.0

→

1.0

1.03-Hydroxy-5-oxohexanoyl-CoA

1.0

1.0Acetyl-CoA + 1.03-Hydroxy-5-oxohexanoate → 1.0Acetic acid + 1.03-Hydroxy-5-oxohexanoyl-CoA + 1.03-Hydroxy-5-oxohexanoyl-CoA
ReactionCard

EcoCyc Reactions:

1.0

→

1.0

1.0Acetoacetic acid + 1.0Acetyl-CoA → 1.0Acetoacetyl-CoA + 1.0Acetic acid
ReactionCard

1.0a 2,3,4-saturated fatty acyl CoA

1.0

↔

1.0a fatty acid

1.0

1.0a 2,3,4-saturated fatty acyl CoA + 1.0Acetic acid ↔ 1.0a fatty acid + 1.0Acetyl-CoA
ReactionCard

Complex Reactions:

1.0

→

1.0

1.0Acetyl-CoA + 1.0Butyric acid → 1.0Acetic acid + 1.0Butyryl-CoA
ReactionCard

1.0

→

1.0

1.0Acetyl-CoA + 1.0Hexanoate (N-C6:0) → 1.0Acetic acid + 1.0Hexanoyl-CoA
ReactionCard

1.0Acyl-CoA

1.0

→

1.0a fatty acid anion

1.0

1.0Acyl-CoA + 1.0Acetic acid → 1.0a fatty acid anion + 1.0Acetyl-CoA
ReactionCard

Metabolites:

ECMDB ID	Name	View
ECMDB20072	3-Hydroxy-5-oxohexanoate	MetaboCard
ECMDB20073	3-Hydroxy-5-oxohexanoyl-CoA	MetaboCard
ECMDB00042	Acetic acid	MetaboCard
ECMDB00060	Acetoacetic acid	MetaboCard
ECMDB01484	Acetoacetyl-CoA	MetaboCard
ECMDB01206	Acetyl-CoA	MetaboCard
ECMDB00039	Butyric acid	MetaboCard
ECMDB01088	Butyryl-CoA	MetaboCard
ECMDB21229	Hexanoate (N-C6:0)	MetaboCard
ECMDB02845	Hexanoyl-CoA	MetaboCard

GO Classification:

Function
catalytic activity
CoA-transferase activity
transferase activity
transferase activity, transferring sulfur-containing groups
Process
metabolic process

Gene Properties

Blattner:

b2222

Gene Orientation

Clockwise

Centisome Percentage:

50.05

Left Sequence End

2322131

Right Sequence End

2322781

Gene Sequence:

>651 bp
ATGAAAGTATCAGTTCCAGGCATGCCGGTTACACTTTTAAATATGAGCAAGAACGATATT
TATAAGATGGTGAGCGGGGACAAGATGGACGTGAAGATGAATATCTTTCAACGCTTGTGG
GAGACGTTACGCCATCTGTTCTGGTCAGATAAACAGACTGAGGCTTATAAACTTCTGTTC
AATTTCGTGAATAACCAGACTGGCAACATCAACGCCTCAGAATACTTTACTGGGGCTATC
AACGAGAATGAGAGAGAAAAGTTTATCAATAGCCTGGAATTATTCAATAAACTTAAAACA
TGCGCAAAAAATCCGGATGAGTTGGTCGCAAAGGGCAATATGCGCTGGGTCGCCCAGACC
TTCGGGGATATCGAGTTAAGTGTCACTTTTTTCATTGAAAAGAATAAGATATGTACTCAG
ACGTTGCAGCTGCATAAGGGCCAAGGTAACTTGGGCGTTGATCTTAGAAAGGCTTACCTT
CCCGGCGTTGACATGAGGGATTGTTACCTTGGTAAAAAAACAATGAAAGGTAGCAATGAT
ATCCTTTATGAGAGACCTGGGTGGAATGCTAACCTGGGCGTGCTACCCCGGACGGTGCTA
CCCCGGACGGTGCTAACCCGGACGGTGCTAACCTGGACGGTGCTACCGTGA

Protein Properties

Pfam Domain Function:

CoA_trans (PF01144 )

Protein Residues:

216

Protein Molecular Weight:

22960

Protein Theoretical pI:

Signaling Regions:

None

Transmembrane Regions:

None

Protein Sequence:

>Acetate CoA-transferase subunit beta
MDAKQRIARRVAQELRDGDIVNLGIGLPTMVANYLPEGIHITLQSENGFLGLGPVTTAHP
DLVNAGGQPCGVLPGAAMFDSAMSFALIRGGHIDACVLGGLQVDEEANLANWVVPGKMVP
GMGGAMDLVTGSRKVIIAMEHCAKDGSAKILRRCTMPLTAQHAVHMLVTELAVFRFIDGK
MWLTEIADGCDLATVRAKTEARFEVAADLNTQRGDL

References

External Links:

Resource	Link
Uniprot ID:	P76459
Uniprot Name:	ATOA_ECOLI
GenBank Gene ID:	AP009048
Genebank Protein ID:	85674305
Ecogene ID:	EG11670
Ecocyc:	EG11670
ColiBase:	b2222
Kegg Gene:	b2222
EchoBASE ID:	EB1621
CCDB:	ATOA_ECOLI
BacMap:	16130159

General Reference:

Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
Itoh, T., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Kasai, H., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Seki, Y., Horiuchi, T., et, a. l. .. (1996). "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." DNA Res 3:379-392. Pubmed: 9097040

Acetate CoA-transferase subunit beta (P76459)