Citrate lyase alpha chain (P75726)

Identification
Name:Citrate lyase alpha chain
Synonyms:
  • Citrase alpha chain
  • Citrate (pro-3S)-lyase alpha chain
  • Citrate CoA-transferase subunit
Gene Name:citF
Enzyme Class:
Biological Properties
General Function:Involved in citrate CoA-transferase activity
Specific Function:Represents a citrate:acetyl-ACP transferase
Cellular Location:Cytoplasm
SMPDB Pathways:Not Available
KEGG Pathways:
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Citric acid ↔ 1.0Acetic acid + 1.0Oxalacetic acid
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Acetyl-CoA + 1.0Citric acid ↔ 1.0Acetic acid + 1.0(3S)-Citryl-CoA
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Citric acid ↔ 1.0Acetic acid + 1.0Oxalacetic acid
ReactionCard
Complex Reactions:
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0Acetyl-CoA + 1.0Citric acid → 1.0Acetic acid + 1.0(3S)-Citryl-CoA
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB23162(3S)-Citryl-CoAMetaboCard
ECMDB00042Acetic acidMetaboCard
ECMDB01206Acetyl-CoAMetaboCard
ECMDB00094Citric acidMetaboCard
ECMDB00223Oxalacetic acidMetaboCard
GO Classification:
Component
cell part
citrate lyase complex
cytoplasm
intracellular part
macromolecular complex
protein complex
Function
catalytic activity
citrate CoA-transferase activity
CoA-transferase activity
transferase activity
transferase activity, transferring sulfur-containing groups
Process
acetyl-CoA metabolic process
cellular metabolic process
coenzyme metabolic process
cofactor metabolic process
metabolic process
Gene Properties
Blattner:b0615
Gene OrientationCounterclockwise
Centisome Percentage:13.95
Left Sequence End647262
Right Sequence End648794
Gene Sequence:
>1533 bp
ATGACGCAGAAAATTGAACAATCTCAACGACAAGAACGGGTAGCGGCCTGGAATCGTCGC
GCTGAATGCGATCTTGCCGCTTTCCAGAACTCGCCAAAGCAAACCTACCAGGCTGAAAAA
GCGCGCGATCGCAAACTGTGCGCCAACCTGGAAGAAGCGATTCGTCGCTCTGGTTTACAG
GACGGCATGACGGTTTCCTTCCATCACGCTTTCCGTGGCGGTGACCTGACCGTCAATATG
GTGATGGACGTCATCGCGAAGATGGGCTTTAAAAACCTGACCCTGGCGTCCAGCTCCCTG
AGTGATTGCCATGCGCCGCTGGTAGAACACATTCGCCAGGGCGTGGTTACCCGCATTTAT
ACCTCCGGCCTGCGTGGTCCACTGGCGGAAGAGATCTCCCGTGGTCTGCTGGCAGAACCG
GTGCAGATCCACTCTCACGGCGGTCGTGTGCATCTGGTACAGAGCGGCGAACTGAATATC
GACGTGGCTTTCCTCGGCGTCCCGTCCTGTGATGAATTCGGTAATGCCAACGGCTACACC
GGTAAAGCCTGCTGCGGCTCCCTCGGCTATGCAATAGTTGATGCCGACAACGCAAAACAG
GTCGTGATGCTTACCGAAGAACTGCTGCCTTATCCGCATAATCCGGCAAGCATTGAGCAA
GATCAGGTTGATTTGATCGTCAAAGTTGACCGCGTTGGCGATGCTGCAAAAATCGGCGCT
GGCGCGACCCGTATGACCACTAACCCGCGCGAACTGCTTATTGCCCGTAGCGCTGCGGAT
GTGATTGTCAACTCTGGCTACTTCAAAGAAGGTTTCTCCATGCAAACCGGCACCGGCGGC
GCATCGCTGGCGGTAACCCGTTTCCTGGAAGACAAAATGCGTAGCCGCGATATTCGCGCC
GACTTCGCCCTTGGCGGTATTACCGCGACGATGGTTGACCTGCACGAAAAAGGTCTGATC
CGCAAACTGCTGGATGTGCAGAGCTTTGACAGCCATGCTGCGCAATCGCTGGCCCGTAAC
CCCAATCACATCGAAATCAGCGCCAACCAGTACGCTAACTGGGGTTCGAAAGGCGCATCG
GTTGATCGTCTCGACGTGGTGGTACTGAGCGCGCTGGAAATTGACACCCAGTTCAACGTT
AACGTGCTGACCGGCTCTGACGGCGTACTGCGTGGTGCTTCCGGTGGTCACTGCGATACC
GCGATTGCCTCTGCGCTTTCCATCATCGTCGCGCCGCTGGTACGCGGTCGTATTCCGACT
CTGGTGGATAACGTACTGACCTGCATCACCCCAGGCTCCAGTGTCGATATTCTGGTCACA
GACCACGGTATCGCAGTTAACCCGGCACGTCCGGAACTGGCAGAACGTCTGCAGGAAGCG
GGCATTAAAGTGGTTTCCATTGAGTGGCTGCGCGAACGTGCGCGTCTGCTGACCGGTGAA
CCACAGCCGATTGAATTCACAGACCGCGTCGTTGCCGTTGTGCGTTACCGCGATGGCTCG
GTGATCGATGTTGTGCATCAGGTGAAGGAATAA
Protein Properties
Pfam Domain Function:
Protein Residues:510
Protein Molecular Weight:55172
Protein Theoretical pI:6
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Citrate lyase alpha chain
MTQKIEQSQRQERVAAWNRRAECDLAAFQNSPKQTYQAEKARDRKLCANLEEAIRRSGLQ
DGMTVSFHHAFRGGDLTVNMVMDVIAKMGFKNLTLASSSLSDCHAPLVEHIRQGVVTRIY
TSGLRGPLAEEISRGLLAEPVQIHSHGGRVHLVQSGELNIDVAFLGVPSCDEFGNANGYT
GKACCGSLGYAIVDADNAKQVVMLTEELLPYPHNPASIEQDQVDLIVKVDRVGDAAKIGA
GATRMTTNPRELLIARSAADVIVNSGYFKEGFSMQTGTGGASLAVTRFLEDKMRSRDIRA
DFALGGITATMVDLHEKGLIRKLLDVQSFDSHAAQSLARNPNHIEISANQYANWGSKGAS
VDRLDVVVLSALEIDTQFNVNVLTGSDGVLRGASGGHCDTAIASALSIIVAPLVRGRIPT
LVDNVLTCITPGSSVDILVTDHGIAVNPARPELAERLQEAGIKVVSIEWLRERARLLTGE
PQPIEFTDRVVAVVRYRDGSVIDVVHQVKE
References
External Links:
ResourceLink
Uniprot ID:P75726
Uniprot Name:CILA_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674724
Ecogene ID:EG13541
Ecocyc:EG13541
ColiBase:b0615
Kegg Gene:b0615
EchoBASE ID:EB3311
CCDB:CILA_ECOLI
BacMap:16128598
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Oshima, T., Aiba, H., Baba, T., Fujita, K., Hayashi, K., Honjo, A., Ikemoto, K., Inada, T., Itoh, T., Kajihara, M., Kanai, K., Kashimoto, K., Kimura, S., Kitagawa, M., Makino, K., Masuda, S., Miki, T., Mizobuchi, K., Mori, H., Motomura, K., Nakamura, Y., Nashimoto, H., Nishio, Y., Saito, N., Horiuchi, T., et, a. l. .. (1996). "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." DNA Res 3:137-155. Pubmed: 8905232