2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (P62707)

Identification
Name:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Synonyms:
  • BPG-dependent PGAM
  • PGAM
  • Phosphoglyceromutase
  • dPGM
Gene Name:gpmA
Enzyme Class:
Biological Properties
General Function:Involved in catalytic activity
Specific Function:Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Cellular Location:Not Available
SMPDB Pathways:
  • fructose metabolism PW000913
  • glycerol metabolism PW000914
  • glycerol metabolism II PW000915
  • glycerol metabolism III (sn-glycero-3-phosphoethanolamine) PW000916
  • glycerol metabolism IV (glycerophosphoglycerol) PW000917
  • glycerol metabolism V (glycerophosphoserine) PW000918
  • glycolysis and pyruvate dehydrogenase PW000785
KEGG Pathways:
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb
1.02-Phospho-D-glyceric acid ↔ 1.03-Phospho-D-glycerate
ReactionCard
1.0Thumb → 1.0Thumb
1.02-Phospho-D-glyceric acid → 1.03-Phospho-D-glycerate
ReactionCard
1.0Thumb+1.0Thumb ↔ 1.0Thumb
1.02-Phospho-D-glyceric acid + 1.02,3-Diphosphoglyceric acid ↔ 1.03-Phospho-D-glycerate
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0Thumb
1.02-Phospho-D-glyceric acid ↔ 1.03-Phosphoglycerate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB041292-Phospho-D-glyceric acidMetaboCard
ECMDB216453-Phospho-D-glycerateMetaboCard
ECMDB041313-PhosphoglycerateMetaboCard
GO Classification:
Function
catalytic activity
intramolecular transferase activity
intramolecular transferase activity, phosphotransferases
isomerase activity
Process
alcohol metabolic process
glucose catabolic process
glucose metabolic process
glycolysis
hexose metabolic process
metabolic process
monosaccharide metabolic process
small molecule metabolic process
Gene Properties
Blattner:b0755
Gene OrientationCounterclockwise
Centisome Percentage:16.94
Left Sequence End786066
Right Sequence End786818
Gene Sequence:
>753 bp
ATGGCTGTAACTAAGCTGGTTCTGGTTCGTCATGGCGAAAGTCAGTGGAACAAAGAAAAC
CGTTTCACCGGTTGGTACGACGTGGATCTGTCTGAGAAAGGCGTAAGCGAAGCAAAAGCA
GCAGGTAAGCTGCTGAAAGAGGAAGGTTACAGCTTTGACTTTGCTTACACTTCTGTGCTG
AAACGCGCTATCCATACCCTGTGGAATGTGCTGGACGAACTGGATCAGGCATGGCTGCCC
GTTGAGAAATCCTGGAAACTGAACGAACGTCACTACGGTGCGTTGCAGGGTCTGAACAAA
GCGGAAACTGCTGAAAAGTATGGCGACGAGCAGGTGAAACAGTGGCGTCGTGGTTTTGCA
GTGACTCCGCCGGAACTGACTAAAGATGATGAGCGTTATCCGGGTCACGATCCGCGTTAC
GCGAAACTGAGCGAGAAAGAACTGCCGCTGACGGAAAGCCTGGCGCTGACCATTGACCGC
GTGATCCCTTACTGGAATGAAACTATTCTGCCGCGTATGAAGAGCGGTGAGCGCGTGATC
ATCGCTGCACACGGTAACTCTTTACGTGCGCTGGTGAAATATCTTGATAACATGAGCGAA
GAAGAGATTCTTGAGCTTAATATCCCGACTGGCGTGCCGCTGGTGTATGAGTTCGACGAG
AATTTCAAACCGCTGAAACGCTATTATCTGGGTAATGCTGACGAGATCGCAGCGAAAGCA
GCGGCGGTTGCAAACCAGGGTAAAGCGAAGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:250
Protein Molecular Weight:28556
Protein Theoretical pI:6
PDB File:1E59
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
MAVTKLVLVRHGESQWNKENRFTGWYDVDLSEKGVSEAKAAGKLLKEEGYSFDFAYTSVL
KRAIHTLWNVLDELDQAWLPVEKSWKLNERHYGALQGLNKAETAEKYGDEQVKQWRRGFA
VTPPELTKDDERYPGHDPRYAKLSEKELPLTESLALTIDRVIPYWNETILPRMKSGERVI
IAAHGNSLRALVKYLDNMSEEEILELNIPTGVPLVYEFDENFKPLKRYYLGNADEIAAKA
AAVANQGKAK
References
External Links:
ResourceLink
Uniprot ID:P62707
Uniprot Name:GPMA_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:4062326
PDB ID:1E59
Ecogene ID:EG11699
Ecocyc:EG11699
ColiBase:b0755
Kegg Gene:b0755
EchoBASE ID:EB1650
CCDB:GPMA_ECOLI
BacMap:16128723
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Bond, C. S., White, M. F., Hunter, W. N. (2001). "High resolution structure of the phosphohistidine-activated form of Escherichia coli cofactor-dependent phosphoglycerate mutase." J Biol Chem 276:3247-3253. Pubmed: 11038361
  • Bond, C. S., White, M. F., Hunter, W. N. (2002). "Mechanistic implications for Escherichia coli cofactor-dependent phosphoglycerate mutase based on the high-resolution crystal structure of a vanadate complex." J Mol Biol 316:1071-1081. Pubmed: 11884145
  • Davies, W. D., Davidson, B. E. (1982). "The nucleotide sequence of aroG, the gene for 3-deoxy-D-arabinoheptulosonate-7-phosphate synthetase (phe) in Escherichia coli K12." Nucleic Acids Res 10:4045-4058. Pubmed: 6125934
  • Fraser, H. I., Kvaratskhelia, M., White, M. F. (1999). "The two analogous phosphoglycerate mutases of Escherichia coli." FEBS Lett 455:344-348. Pubmed: 10437801
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Link, A. J., Robison, K., Church, G. M. (1997). "Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12." Electrophoresis 18:1259-1313. Pubmed: 9298646
  • Nystrom, T., Larsson, C., Gustafsson, L. (1996). "Bacterial defense against aging: role of the Escherichia coli ArcA regulator in gene expression, readjusted energy flux and survival during stasis." EMBO J 15:3219-3228. Pubmed: 8670822
  • Oshima, T., Aiba, H., Baba, T., Fujita, K., Hayashi, K., Honjo, A., Ikemoto, K., Inada, T., Itoh, T., Kajihara, M., Kanai, K., Kashimoto, K., Kimura, S., Kitagawa, M., Makino, K., Masuda, S., Miki, T., Mizobuchi, K., Mori, H., Motomura, K., Nakamura, Y., Nashimoto, H., Nishio, Y., Saito, N., Horiuchi, T., et, a. l. .. (1996). "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." DNA Res 3:137-155. Pubmed: 8905232
  • Vassinova, N., Kozyrev, D. (2000). "A method for direct cloning of fur-regulated genes: identification of seven new fur-regulated loci in Escherichia coli." Microbiology 146 Pt 12:3171-3182. Pubmed: 11101675
  • Wilkins, M. R., Gasteiger, E., Tonella, L., Ou, K., Tyler, M., Sanchez, J. C., Gooley, A. A., Walsh, B. J., Bairoch, A., Appel, R. D., Williams, K. L., Hochstrasser, D. F. (1998). "Protein identification with N and C-terminal sequence tags in proteome projects." J Mol Biol 278:599-608. Pubmed: 9600841
  • Zhang, J., Sprung, R., Pei, J., Tan, X., Kim, S., Zhu, H., Liu, C. F., Grishin, N. V., Zhao, Y. (2009). "Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli." Mol Cell Proteomics 8:215-225. Pubmed: 18723842