Identification
Name:Undecaprenyl-diphosphatase
Synonyms:
  • Bacitracin resistance protein
  • Undecaprenyl pyrophosphate phosphatase
Gene Name:uppP
Enzyme Class:
Biological Properties
General Function:Involved in undecaprenyl-diphosphatase activity
Specific Function:Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:Not Available
KEGG Pathways:
KEGG Reactions:
1.0di-trans,poly-cis-Undecaprenyl diphosphate+1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb
1.0di-trans,poly-cis-Undecaprenyl diphosphate + 1.0Water + 1.0Undecaprenyl diphosphate ↔ 1.0Di-trans,poly-cis-undecaprenyl phosphate + 1.0Phosphate
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb+1.0Thumb
Complex Reactions:
1.0Thumb+1.0Thumb1.0Thumb+1.0Thumb+1.0Thumb
Metabolites:
ECMDB IDNameView
ECMDB20310Di-trans,poly-cis-undecaprenyl phosphateMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB21380Inorganic phosphateMetaboCard
ECMDB01429PhosphateMetaboCard
ECMDB01469Undecaprenyl diphosphateMetaboCard
ECMDB20208Undecaprenyl phosphateMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Component
cell part
membrane
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
pyrophosphatase activity
undecaprenyl-diphosphatase activity
Process
cellular metabolic process
dephosphorylation
metabolic process
phosphate metabolic process
phosphorus metabolic process
Gene Properties
Blattner:b3057
Gene OrientationCounterclockwise
Centisome Percentage:69.00
Left Sequence End3201332
Right Sequence End3202153
Gene Sequence:
>822 bp
ATGCATGATGCAAACATCCGCGTTGCCATCGCGGGAGCCGGGGGGCGTATGGGCCGCCAG
TTGATTCAGGCGGCGCTGGCATTAGAGGGCGTGCAGTTGGGCGCTGCGCTGGAGCGTGAA
GGATCTTCTTTACTGGGCAGCGACGCCGGTGAGCTGGCCGGAGCCGGGAAAACAGGCGTT
ACCGTGCAAAGCAGCCTCGATGCGGTAAAAGATGATTTTGATGTGTTTATCGATTTTACC
CGTCCGGAAGGTACGCTGAACCATCTCGCTTTTTGTCGCCAGCATGGCAAAGGGATGGTG
ATCGGCACTACGGGGTTTGACGAAGCCGGTAAACAAGCAATTCGTGACGCCGCTGCCGAT
ATTGCGATTGTCTTTGCTGCCAATTTTAGCGTTGGCGTTAACGTCATGCTTAAGCTGCTG
GAGAAAGCAGCCAAAGTGATGGGTGACTACACCGATATCGAAATTATTGAAGCACATCAT
AGACATAAAGTTGATGCGCCGTCAGGCACCGCACTGGCAATGGGAGAGGCGATCGCCCAC
GCCCTTGATAAAGATCTGAAAGATTGCGCGGTCTACAGTCGTGAAGGCCACACCGGTGAA
CGTGTGCCTGGCACCATTGGTTTTGCCACCGTGCGTGCAGGTGACATCGTTGGTGAACAT
ACCGCGATGTTTGCCGATATTGGCGAGCGTCTGGAGATCACCCATAAGGCGTCCAGCCGT
ATGACATTTGCTAACGGCGCGGTAAGATCGGCTTTGTGGTTGAGTGGTAAGGAAAGCGGT
CTTTTTGATATGCGAGATGTACTTGATCTCAATAATTTGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:273
Protein Molecular Weight:29758
Protein Theoretical pI:8
Signaling Regions:
  • None
Transmembrane Regions:
  • 6-26
  • 45-65
  • 90-110
  • 116-136
  • 190-210
  • 222-242
  • 252-272
Protein Sequence:
>Undecaprenyl-diphosphatase
MSDMHSLLIAAILGVVEGLTEFLPVSSTGHMIIVGHLLGFEGDTAKTFEVVIQLGSILAV
VVMFWRRLFGLIGIHFGRPLQHEGESKGRLTLIHILLGMIPAVVLGLLFHDTIKSLFNPI
NVMYALVVGGLLLIAAECLKPKEPRAPGLDDMTYRQAFMIGCFQCLALWPGFSRSGATIS
GGMLMGVSRYAASEFSFLLAVPMMMGATALDLYKSWGFLTSGDIPMFAVGFITAFVVALI
AIKTFLQLIKRISFIPFAIYRFIVAAAVYVVFF
References
External Links:
ResourceLink
Uniprot ID:P60932
Uniprot Name:UPPP_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:21321913
Ecogene ID:EG11665
Ecocyc:EG11665
ColiBase:b3057
Kegg Gene:b3057
EchoBASE ID:EB1616
CCDB:UPPP_ECOLI
BacMap:16130953
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Cain, B. D., Norton, P. J., Eubanks, W., Nick, H. S., Allen, C. M. (1993). "Amplification of the bacA gene confers bacitracin resistance to Escherichia coli." J Bacteriol 175:3784-3789. Pubmed: 8389741
  • Cudny, H., Lupski, J. R., Godson, G. N., Deutscher, M. P. (1986). "Cloning, sequencing, and species relatedness of the Escherichia coli cca gene encoding the enzyme tRNA nucleotidyltransferase." J Biol Chem 261:6444-6449. Pubmed: 3009457
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • El Ghachi, M., Bouhss, A., Blanot, D., Mengin-Lecreulx, D. (2004). "The bacA gene of Escherichia coli encodes an undecaprenyl pyrophosphate phosphatase activity." J Biol Chem 279:30106-30113. Pubmed: 15138271
  • El Ghachi, M., Derbise, A., Bouhss, A., Mengin-Lecreulx, D. (2005). "Identification of multiple genes encoding membrane proteins with undecaprenyl pyrophosphate phosphatase (UppP) activity in Escherichia coli." J Biol Chem 280:18689-18695. Pubmed: 15778224
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553