| Identification |
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| Name: | GTP-binding protein lepA |
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| Synonyms: | Not Available |
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| Gene Name: | lepA |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | Cell wall/membrane/envelope biogenesis |
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| Specific Function: | Not Available |
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| Cellular Location: | Cell membrane. Periplasm |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Complex Reactions: | |
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| Metabolites: | |
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| GO Classification: | | Function |
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| binding | | catalytic activity | | GTP binding | | GTPase activity | | guanyl nucleotide binding | | guanyl ribonucleotide binding | | hydrolase activity | | hydrolase activity, acting on acid anhydrides | | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | | nucleoside-triphosphatase activity | | nucleotide binding | | purine nucleotide binding | | pyrophosphatase activity |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >1800 bp
ATGAAGAATATACGTAACTTTTCGATCATAGCTCACATTGACCACGGTAAATCGACGCTG
TCTGACCGTATTATCCAGATCTGCGGTGGCCTGTCTGACCGTGAAATGGAGGCGCAGGTT
CTCGATTCCATGGATCTTGAGCGTGAGCGTGGCATTACCATCAAAGCGCAAAGCGTGACG
CTGGACTACAAAGCGTCTGACGGCGAAACCTATCAGCTTAACTTTATCGACACCCCGGGC
CACGTAGACTTCTCCTATGAAGTTTCCCGTTCGCTGGCTGCCTGTGAAGGTGCATTGCTG
GTGGTCGACGCCGGGCAGGGCGTAGAAGCGCAAACCCTGGCAAACTGCTACACCGCCATG
GAAATGGATCTCGAAGTTGTGCCGGTACTGAACAAGATTGACCTGCCGGCAGCCGATCCT
GAACGCGTGGCGGAAGAAATTGAAGATATCGTCGGCATCGACGCCACCGACGCGGTGCGC
TGTTCAGCGAAAACCGGCGTTGGTGTGCAGGACGTTCTCGAACGTCTGGTGCGCGACATT
CCGCCGCCGGAAGGCGATCCGGAAGGCCCGTTGCAGGCACTAATTATCGACTCATGGTTC
GACAACTACCTGGGCGTTGTTTCACTTATCCGTATTAAAAACGGCACCCTGCGTAAGGGC
GACAAAGTGAAAGTCATGAGTACCGGGCAGACCTATAACGCCGACCGTCTGGGCATCTTC
ACGCCGAAACAGGTTGACCGCACTGAACTGAAATGTGGCGAAGTAGGCTGGCTCGTATGT
GCGATTAAAGATATCCACGGCGCTCCAGTCGGCGATACCTTAACGCTGGCGCGTAATCCG
GCAGAAAAGGCGCTGCCTGGCTTTAAGAAAGTCAAACCGCAGGTATACGCCGGTCTGTTC
CCGGTAAGTTCCGACGACTATGAAGCCTTCCGTGACGCGCTGGGTAAACTCAGCCTGAAC
GATGCCTCACTGTTCTATGAGCCGGAAAGCTCCAGCGCGCTGGGCTTTGGTTTCCGCTGC
GGCTTCCTCGGCCTGCTGCACATGGAGATCATCCAGGAACGTCTGGAACGTGAATACGAT
CTGGATCTGATCACCACTGCGCCGACCGTAGTGTATGAAGTTGAAACCACGTCAAGAGAA
GTTATCTACGTCGACAGCCCATCCAAGCTGCCTGCGGTAAATAACATCTACGAACTGCGC
GAGCCGATTGCAGAGTGTCACATGCTGCTGCCGCAGGCATATCTCGGCAACGTTATTACG
TTGTGCGTAGAAAAACGCGGCGTGCAGACCAATATGGTTTACCACGGTAATCAGGTGGCG
CTGACGTACGAGATCCCGATGGCGGAAGTGGTGCTCGACTTCTTCGATCGCCTGAAATCT
ACCTCGCGTGGTTATGCGTCTCTGGATTACAACTTCAAGCGCTTCCAGGCGTCCGACATG
GTACGTGTAGACGTATTAATCAACGGTGAACGTGTTGATGCGCTGGCGTTGATCACCCAC
CGTGATAATTCGCAAAACCGCGGTCGCGAGTTGGTGGAGAAGATGAAAGATCTGATCCCA
CGCCAGCAGTTTGATATCGCCATTCAGGCAGCGATTGGTACGCACATCATTGCGCGATCC
ACCGTGAAACAGCTGCGTAAAAACGTACTGGCTAAATGTTATGGCGGCGATATCAGCCGT
AAGAAAAAGCTGCTGCAGAAGCAGAAAGAAGGTAAGAAACGCATGAAGCAGATCGGTAAC
GTCGAGCTGCCGCAGGAAGCGTTCCTCGCCATTCTGCACGTCGGCAAAGACAACAAATAA
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| Protein Properties |
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| Pfam Domain Function: | |
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| Protein Residues: | 599 |
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| Protein Molecular Weight: | 66570 |
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| Protein Theoretical pI: | 5 |
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| Signaling Regions: | |
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| Transmembrane Regions: | |
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| Protein Sequence: | >GTP-binding protein lepA
MKNIRNFSIIAHIDHGKSTLSDRIIQICGGLSDREMEAQVLDSMDLERERGITIKAQSVT
LDYKASDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAM
EMDLEVVPVLNKIDLPAADPERVAEEIEDIVGIDATDAVRCSAKTGVGVQDVLERLVRDI
PPPEGDPEGPLQALIIDSWFDNYLGVVSLIRIKNGTLRKGDKVKVMSTGQTYNADRLGIF
TPKQVDRTELKCGEVGWLVCAIKDIHGAPVGDTLTLARNPAEKALPGFKKVKPQVYAGLF
PVSSDDYEAFRDALGKLSLNDASLFYEPESSSALGFGFRCGFLGLLHMEIIQERLEREYD
LDLITTAPTVVYEVETTSREVIYVDSPSKLPAVNNIYELREPIAECHMLLPQAYLGNVIT
LCVEKRGVQTNMVYHGNQVALTYEIPMAEVVLDFFDRLKSTSRGYASLDYNFKRFQASDM
VRVDVLINGERVDALALITHRDNSQNRGRELVEKMKDLIPRQQFDIAIQAAIGTHIIARS
TVKQLRKNVLAKCYGGDISRKKKLLQKQKEGKKRMKQIGNVELPQEAFLAILHVGKDNK |
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| References |
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| External Links: | |
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| General Reference: | - Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
- Kushiro, M., Shimizu, M., Tomita, K. (1987). "Molecular cloning and sequence determination of the tuf gene coding for the elongation factor Tu of Thermus thermophilus HB8." Eur J Biochem 170:93-98. Pubmed: 2826164
- March, P. E., Inouye, M. (1985). "Characterization of the lep operon of Escherichia coli. Identification of the promoter and the gene upstream of the signal peptidase I gene." J Biol Chem 260:7206-7213. Pubmed: 2987248
- March, P. E., Inouye, M. (1985). "GTP-binding membrane protein of Escherichia coli with sequence homology to initiation factor 2 and elongation factors Tu and G." Proc Natl Acad Sci U S A 82:7500-7504. Pubmed: 2999765
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