Crotonobetainyl-CoA dehydrogenase (P60584)

Identification
Name:Crotonobetainyl-CoA dehydrogenase
Synonyms:
  • Crotonobetainyl-CoA reductase
Gene Name:caiA
Enzyme Class:Not Available
Biological Properties
General Function:Involved in acyl-CoA dehydrogenase activity
Specific Function:Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:Not Available
SMPDB Reactions:
1.0Thumb+1.0reduced electron acceptor → 1.0Thumb+1.0oxidized electron acceptor
1.0Crotonobetainyl-CoA + 1.0reduced electron acceptor → 1.0gamma-Butyrobetainyl-CoA + 1.0oxidized electron acceptor
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0an oxidized electron acceptor ↔ 1.0Thumb+1.0a reduced electron acceptor
1.0gamma-Butyrobetainyl-CoA + 1.0an oxidized electron acceptor ↔ 1.0Crotonobetainyl-CoA + 1.0a reduced electron acceptor
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB20539Crotonobetainyl-CoAMetaboCard
ECMDB20559gamma-Butyrobetainyl-CoAMetaboCard
GO Classification:
Function
acyl-CoA dehydrogenase activity
adenyl nucleotide binding
binding
catalytic activity
FAD or FADH2 binding
nucleoside binding
oxidoreductase activity
oxidoreductase activity, acting on the CH-CH group of donors
purine nucleoside binding
Process
metabolic process
oxidation reduction
Gene Properties
Blattner:b0039
Gene OrientationCounterclockwise
Centisome Percentage:0.85
Left Sequence End39244
Right Sequence End40386
Gene Sequence:
>1143 bp
ATGGATTTTAATTTAAATGATGAGCAGGAACTGTTTGTCGCCGGTATCCGCGAACTGATG
GCCAGCGAAAACTGGGAGGCCTATTTTGCCGAGTGCGACCGTGACAGCGTCTACCCGGAA
CGTTTTGTCAAAGCACTGGCGGATATGGGTATCGACAGTCTGCTGATCCCTGAAGAGCAC
GGTGGTCTGGACGCGGGGTTTGTTACTCTCGCCGCCGTGTGGATGGAGCTGGGACGTCTG
GGGGCACCAACCTATGTGCTGTACCAGTTGCCGGGCGGGTTCAACACCTTCCTGCGCGAA
GGCACACAAGAGCAGATCGACAAAATTATGGCTTTCCGCGGCACCGGTAAGCAGATGTGG
AACTCAGCGATTACCGAACCGGGCGCGGGCTCCGACGTGGGTAGCCTGAAAACGACTTAT
ACCCGTAGAAATGGTAAGATTTATCTTAATGGTAGTAAGTGTTTTATTACCAGCAGCGCC
TACACCCCGTACATCGTGGTGATGGCGCGCGACGGGGCTTCTCCGGACAAACCTGTCTAC
ACCGAATGGTTTGTTGATATGAGCAAACCGGGCATCAAAGTGACCAAACTTGAAAAGCTC
GGTCTGCGTATGGATAGCTGCTGTGAAATCACCTTTGACGACGTGGAACTGGACGAGAAA
GACATGTTCGGTCGGGAAGGTAACGGCTTTAACCGCGTCAAAGAAGAGTTCGACCATGAA
CGTTTCCTGGTAGCCCTCACCAACTACGGTACGGCGATGTGCGCCTTTGAAGATGCGGCG
CGCTACGCCAATCAGCGCGTGCAGTTTGGCGAGGCTATTGGTCGTTTCCAGTTGATTCAG
GAAAAATTCGCCCACATGGCGATCAAATTAAACTCCATGAAAAACATGCTGTATGAAGCA
GCGTGGAAAGCAGACAACGGCACCATCACCTCTGGCGATGCAGCGATGTGCAAATACTTC
TGCGCCAATGCGGCATTTGAAGTTGTGGATAGCGCAATGCAGGTGCTGGGCGGTGTCGGG
ATTGCGGGCAACCACCGCATCAGCCGCTTCTGGCGTGATCTGCGTGTAGACCGCGTCTCC
GGGGGATCTGACGAAATGCAGATCCTGACGCTGGGTCGTGCGGTGCTGAAGCAATACCGC
TAA
Protein Properties
Pfam Domain Function:
Protein Residues:380
Protein Molecular Weight:42558
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Crotonobetainyl-CoA dehydrogenase
MDFNLNDEQELFVAGIRELMASENWEAYFAECDRDSVYPERFVKALADMGIDSLLIPEEH
GGLDAGFVTLAAVWMELGRLGAPTYVLYQLPGGFNTFLREGTQEQIDKIMAFRGTGKQMW
NSAITEPGAGSDVGSLKTTYTRRNGKIYLNGSKCFITSSAYTPYIVVMARDGASPDKPVY
TEWFVDMSKPGIKVTKLEKLGLRMDSCCEITFDDVELDEKDMFGREGNGFNRVKEEFDHE
RFLVALTNYGTAMCAFEDAARYANQRVQFGEAIGRFQLIQEKFAHMAIKLNSMKNMLYEA
AWKADNGTITSGDAAMCKYFCANAAFEVVDSAMQVLGGVGIAGNHRISRFWRDLRVDRVS
GGSDEMQILTLGRAVLKQYR
References
External Links:
ResourceLink
Uniprot ID:P60584
Uniprot Name:CAIA_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674294
Ecogene ID:EG11560
Ecocyc:EG11560
ColiBase:b0039
Kegg Gene:b0039
EchoBASE ID:EB1521
CCDB:CAIA_ECOLI
BacMap:16128033
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Eichler, K., Bourgis, F., Buchet, A., Kleber, H. P., Mandrand-Berthelot, M. A. (1994). "Molecular characterization of the cai operon necessary for carnitine metabolism in Escherichia coli." Mol Microbiol 13:775-786. Pubmed: 7815937
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Preusser, A., Wagner, U., Elssner, T., Kleber, H. P. (1999). "Crotonobetaine reductase from Escherichia coli consists of two proteins." Biochim Biophys Acta 1431:166-178. Pubmed: 10209289
  • Yura, T., Mori, H., Nagai, H., Nagata, T., Ishihama, A., Fujita, N., Isono, K., Mizobuchi, K., Nakata, A. (1992). "Systematic sequencing of the Escherichia coli genome: analysis of the 0-2.4 min region." Nucleic Acids Res 20:3305-3308. Pubmed: 1630901