Xanthosine permease (P45562)

Identification
Name:Xanthosine permease
Synonyms:
  • Xanthosine transporter
Gene Name:xapB
Enzyme Class:Not Available
Biological Properties
General Function:Involved in nucleoside transmembrane transporter activity
Specific Function:Nucleoside transport
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:
KEGG Pathways:Not Available
Transports:
Transport References:
  • Orth, J. D., Conrad, T. M., Na, J., Lerman, J. A., Nam, H., Feist, A. M., Palsson, B. O. (2011). "A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011." Mol Syst Biol 7:535. Pubmed: 21988831
  • Uniprot Consortium (2012). "Reorganizing the protein space at the Universal Protein Resource (UniProt)." Nucleic Acids Res 40:D71-D75. Pubmed: 22102590
Metabolites:
ECMDB IDNameView
ECMDB00050AdenosineMetaboCard
ECMDB00089CytidineMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB00195InosineMetaboCard
ECMDB00273ThymidineMetaboCard
ECMDB00296UridineMetaboCard
ECMDB00299XanthosineMetaboCard
GO Classification:
Component
cell part
integral to membrane
intrinsic to membrane
membrane part
Function
nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity
nucleoside transmembrane transporter activity
substrate-specific transmembrane transporter activity
transmembrane transporter activity
transporter activity
Process
establishment of localization
nucleobase, nucleoside, nucleotide and nucleic acid transport
nucleoside transport
transport
Gene Properties
Blattner:b2406
Gene OrientationCounterclockwise
Centisome Percentage:54.33
Left Sequence End2520751
Right Sequence End2522007
Gene Sequence:
>1257 bp
ATGGGTAGTAATATACATGGAATTAGTTGCACTGCAAATAATTATTTGAAACAGGCCTGG
AACGATATAAAAAATGAGTACGAAAAAAATCAAACATATTCAATCACGCTTTTTGAAAAC
ACACTGGTGTGTTTTATGCGGTTATACAATGAACTCAGACGTAAAGTAAATGAAGAGGAT
ACTCCATGTCTGGAATGTGAATCACTAGAAAAAGAATTTGAGGAAATGCAGAATGATAAT
GATCTATCATTATTTATGAGAATATTGCGTACTAATGATACACAAATTTATTCAGGGGTT
TCAGGAGGTATTACATATACTATACAATATGTTCGAGATATTGATATTGTTAGAGTGTCC
TTGCCGGGCAGAGCTTCAGAGTCTATCACAGATTTTAAAGGTTATTATTGGTATAACTTT
ATGGAGTATATTGAAAACATTAATGCGTGTGATGATGTTTTTTCTGAGTATTGTTTTGAT
GATGAAAATATAAGTGTCCAGCCAGAGCGGATAAATACGCCGGGAATATCTGATTTGGAT
TCTGACATTGATTTGTCTGGTATATCTTTTATTCAGCGTGAAACTAACCAGGCATTAGGA
TTAAAATATGCTCCTGTAGATGGCGATGGATATTGTCTGTTAAGAGCTATACTGGTTTTA
AAACAACATGATTATTCATGGGCGCTGGTCAGTTATAAGATGCAAAAGGAAGTTTACAAC
GAATTCATTAAAATGGTTGATAAAAAAACGATCGAGGCTCTTGTTGATACGGCATTCTAT
AATCTCAGGGAAGATGTAAAGACGTTATTTGGCGTTGATCTACAATCTGACAACCAAATT
CAGGGGCAGAGTAGTCTTATGTCATGGAGCTTTCTGTTTTTTAAAAAACAATTCATTGAT
AGTTGCTTGAATAACGAAAAATGTATCCTGCATTTACCCGAGTTTATATTTAATGATAAC
AAGAACTTGCTTGCTTTAGATACCGACACGTCGGATAGGATTAAAGCGGTGAAGAATTTT
CTTGTTGTTCTTTCAGATAGCATTTGCTCATTATTTATTGTTAATAGTAATGTGGCATCA
ATCTCCTTGGGGAATGAATCCTTTTCAACAGATGAAGATCTTGAGTATGGTTATTTAATG
AACACTGGCAATCATTATGACGTTTACCTCCCTCCTGAACTTTTTGCTCAGGCTTACAAG
TTAAACAATAAGGAAATGAATGCGCAACTCGACTATTTAAATCGTTATGCAATTTAA
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:418
Protein Molecular Weight:46139
Protein Theoretical pI:9
Signaling Regions:
  • None
Transmembrane Regions:
  • 10-30
  • 42-62
  • 71-91
  • 92-112
  • 137-157
  • 160-180
  • 210-230
  • 255-275
  • 278-298
  • 307-327
  • 349-369
  • 382-402
Protein Sequence:
>Xanthosine permease
MSIAMRLKVMSFLQYFIWGSWLVTLGSYMINTLHFTGANVGMVYSSKGIAAIIMPGIMGI
IADKWLRAERAYMLCHLVCAGVLFYAASVTDPDMMFWVMLVNAMAFMPTIALSNSVSYSC
LAQAGLDPVTAFPPIRVFGTVGFIVAMWAVSLLHLELSSLQLYIASGASLLLSAYALTLP
KIPVAEKKATTSLASKLGLDAFVLFKNPRMAIFFLFAMMLGAVLQITNVFGNPFLHDFAR
NPEFADSFVVKYPSILLSVSQMAEVGFILTIPFFLKRFGIKTVMLMSMVAWTLRFGFFAY
GDPSTTGFILLLLSMIVYGCAFDFFNISGSVFVEQEVDSSIRASAQGLFMTMVNGVGAWV
GSILSGMAVDYFSVDGVKDWQTIWLVFAGYALFLAVIFFFGFKYNHDPEKIKHRAVTH
References
External Links:
ResourceLink
Uniprot ID:P45562
Uniprot Name:XAPB_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:4062556
Ecogene ID:EG13159
Ecocyc:EG13159
ColiBase:b2406
Kegg Gene:b2406
EchoBASE ID:EB2951
CCDB:XAPB_ECOLI
BacMap:16130332
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Seeger, C., Poulsen, C., Dandanell, G. (1995). "Identification and characterization of genes (xapA, xapB, and xapR) involved in xanthosine catabolism in Escherichia coli." J Bacteriol 177:5506-5516. Pubmed: 7559336
  • Yamamoto, Y., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Itoh, T., Kimura, S., Kitagawa, M., Makino, K., Miki, T., Mitsuhashi, N., Mizobuchi, K., Mori, H., Nakade, S., Nakamura, Y., Nashimoto, H., Oshima, T., Oyama, S., Saito, N., Sampei, G., Satoh, Y., Sivasundaram, S., Tagami, H., Horiuchi, T., et, a. l. .. (1997). "Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features." DNA Res 4:91-113. Pubmed: 9205837