Tyrosine-protein kinase etk (P38134)

Identification
Name:Tyrosine-protein kinase etk
Synonyms:Not Available
Gene Name:etk
Enzyme Class:Not Available
Biological Properties
General Function:Cell wall/membrane/envelope biogenesis
Specific Function:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Cellular Location:Cell inner membrane; Multi-pass membrane protein.
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Complex Reactions:
1.0Thumb+1.0a [protein]-L-tyrosine → 1.0Thumb+1.0a [protein]-L-tyrosine phosphate
1.0Adenosine triphosphate + 1.0a [protein]-L-tyrosine → 1.0ADP + 1.0a [protein]-L-tyrosine phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00538Adenosine triphosphateMetaboCard
ECMDB01341ADPMetaboCard
GO Classification:
Component
cell part
membrane
Function
enzyme regulator activity
Process
capsule polysaccharide biosynthetic process
carbohydrate metabolic process
cellular polysaccharide biosynthetic process
extracellular polysaccharide biosynthetic process
lipid biosynthetic process
lipid metabolic process
lipopolysaccharide biosynthetic process
metabolic process
polysaccharide biosynthetic process
polysaccharide metabolic process
primary metabolic process
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>2181 bp
ATGACAACTAAAAATATGAATACGCCACCAGGCAGCACTCAGGAAAATGAGATCGATCTG
CTTCGTCTGGTCGGCGAGTTATGGGATCACCGTAAGTTTATTATCAGCGTGACCGCGTTA
TTCACGCTGATCGCTGTCGCTTACTCGCTGTTAAGCACACCAATTTATCAGGCAGATACT
CTGGTCCAGGTTGAGCAAAAACAGGGCAACGCCATTCTCAGCGGCCTGAGCGATATGATC
CCTAACTCATCGCCCGAGTCTGCACCGGAGATCCAACTGCTGCAATCGCGCATGATTCTC
GGTAAAACCATTGCTGAACTGAATCTGCGCGACATAGTTGAGCAGAAGTATTTTCCGATT
GTGGGTCGCGGCTGGGCGAGATTAACCAAAGAAAAACCAGGTGAGCTGGCGATCAGCTGG
ATGCATATTCCACAACTGAATGGTCAGGATCAGCAACTGACACTCACGGTTGGGGAAAAC
GGCCACTATACACTGGAAGGTGAAGAGTTCACCGTCAATGGTATGGTCGGCCAGCGTCTG
GAAAAAGATGGCGTTGCGCTGACTATCGCGGACATTAAGGCCAAACCAGGAACACAGTTT
GTCCTGAGCCAGCGTACCGAACTGGAAGCGATTAACGCATTGCAGGAAACCTTTACCGTT
AGCGAACGCAGTAAAGAAAGCGGGATGCTGGAACTTACCATGACTGGTGATGATCCCCAG
TTGATTACTCGTATTCTGAACAGCATCGCTAACAACTATTTGCAACAGAATATCGCTCGC
CAGGCGGCGCAGGATTCACAAAGCCTTGAATTCTTACAGCGCCAGTTACCTGAAGTGCGC
AGCGAGCTGGACCAAGCGGAAGAAAAACTCAACGTTTATCGCCAGCAGCGCGATTCGGTT
GACCTTAACCTGGAAGCCAAAGCCGTTCTTGAGCAGATTGTGAACGTTGATAATCAACTC
AATGAGCTGACCTTCCGCGAGGCAGAGATCTCCCAGCTGTATAAGAAAGATCACCCAACT
TATCGTGCGCTGCTGGAAAAACGCCAGACGCTGGAGCAAGAACGCAAACGCCTGAATAAG
CGGGTATCGGCAATGCCTTCCACCCAACAGGAAGTGTTGCGTTTAAGTCGTGACGTAGAA
GCGGGCCGTGCGGTATATCTGCAATTACTTAACCGCCAGCAGGAGTTGAGTATTTCGAAA
TCCAGTGCCATTGGTAACGTGCGGATTATCGACCCGGCAGTCACTCAGCCGCAGCCAGTG
AAACCGAAAAAAGCGTTGAACGTGGTGCTTGGTTTTATTCTTGGCCTGTTTATTTCTGTG
GGTGCCGTGCTGGCGCGTGCGATGTTGCGTCGTGGTGTAGAAGCCCCGGAACAACTGGAA
GAGCACGGCATCAGCGTTTATGCCACTATCCCAATGTCCGAGTGGCTGGATAAACGCACC
CGTCTGCGTAAGAAAAATTTATTTTCTAATCAGCAGCGCCATCGTACTAAAAATATCCCC
TTCCTGGCGGTGGATAACCCGGCGGATTCTGCTGTGGAAGCCGTACGTGCGCTACGAACC
AGTCTGCATTTCGCTATGATGGAGACGGAGAATAACATTCTAATGATCACCGGTGCGACG
CCAGACAGTGGTAAAACGTTTGTCAGTTCAACTCTGGCAGCGGTGATCGCCCAGTCCGAT
CAAAAAGTGTTATTTATTGATGCCGACTTACGCCGTGGTTATTCGCATAACCTGTTTACC
GTGAGTAATGAACATGGCTTGTCGGAATATCTGGCAGGTAAAGATGAGCTCAACAAAGTG
ATCCAGCATTTTGGCAAAGGAGGCTTTGATGTGATTACTCGCGGTCAGGTGCCACCTAAC
CCGTCTGAACTGCTGATGCGCGATCGGATGCGTCAATTACTGGAATGGGCGAACGACCAT
TACGATCTGGTGATTGTCGATACGCCGCCGATGCTGGCGGTGAGTGATGCCGCGGTCGTG
GGGCGTTCTGTTGGCACCAGCCTGCTGGTTGCGCGTTTTGGCTTGAACACCGCCAAAGAG
GTGAGTTTGTCAATGCAGCGTCTGGAACAGGCAGGCGTCAATATTAAAGGCGCTATCCTC
AATGGTGTGATTAAACGCGCCAGCACCGCTTACAGTTACGGCTATAACTATTACGGTTAT
AGTTACTCCGAGAAAGAGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:726
Protein Molecular Weight:81241
Protein Theoretical pI:7
Signaling Regions:
  • None
Transmembrane Regions:
  • 33-53
  • 425-445
Protein Sequence:
>Tyrosine-protein kinase etk
MTTKNMNTPPGSTQENEIDLLRLVGELWDHRKFIISVTALFTLIAVAYSLLSTPIYQADT
LVQVEQKQGNAILSGLSDMIPNSSPESAPEIQLLQSRMILGKTIAELNLRDIVEQKYFPI
VGRGWARLTKEKPGELAISWMHIPQLNGQDQQLTLTVGENGHYTLEGEEFTVNGMVGQRL
EKDGVALTIADIKAKPGTQFVLSQRTELEAINALQETFTVSERSKESGMLELTMTGDDPQ
LITRILNSIANNYLQQNIARQAAQDSQSLEFLQRQLPEVRSELDQAEEKLNVYRQQRDSV
DLNLEAKAVLEQIVNVDNQLNELTFREAEISQLYKKDHPTYRALLEKRQTLEQERKRLNK
RVSAMPSTQQEVLRLSRDVEAGRAVYLQLLNRQQELSISKSSAIGNVRIIDPAVTQPQPV
KPKKALNVVLGFILGLFISVGAVLARAMLRRGVEAPEQLEEHGISVYATIPMSEWLDKRT
RLRKKNLFSNQQRHRTKNIPFLAVDNPADSAVEAVRALRTSLHFAMMETENNILMITGAT
PDSGKTFVSSTLAAVIAQSDQKVLFIDADLRRGYSHNLFTVSNEHGLSEYLAGKDELNKV
IQHFGKGGFDVITRGQVPPNPSELLMRDRMRQLLEWANDHYDLVIVDTPPMLAVSDAAVV
GRSVGTSLLVARFGLNTAKEVSLSMQRLEQAGVNIKGAILNGVIKRASTAYSYGYNYYGY
SYSEKE
References
External Links:
ResourceLink
Uniprot ID:P38134
Uniprot Name:ETK_ECOLI
GenBank Gene ID:U00096
Genebank Protein ID:1787216
CCDB:ETK_ECOLI
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Borodovsky, M., Rudd, K. E., Koonin, E. V. (1994). "Intrinsic and extrinsic approaches for detecting genes in a bacterial genome." Nucleic Acids Res 22:4756-4767. Pubmed: 7984428
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Dassa, J., Marck, C., Boquet, P. L. (1990). "The complete nucleotide sequence of the Escherichia coli gene appA reveals significant homology between pH 2.5 acid phosphatase and glucose-1-phosphatase." J Bacteriol 172:5497-5500. Pubmed: 2168385
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Oshima, T., Aiba, H., Baba, T., Fujita, K., Hayashi, K., Honjo, A., Ikemoto, K., Inada, T., Itoh, T., Kajihara, M., Kanai, K., Kashimoto, K., Kimura, S., Kitagawa, M., Makino, K., Masuda, S., Miki, T., Mizobuchi, K., Mori, H., Motomura, K., Nakamura, Y., Nashimoto, H., Nishio, Y., Saito, N., Horiuchi, T., et, a. l. .. (1996). "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." DNA Res 3:137-155. Pubmed: 8905232
  • Vincent, C., Duclos, B., Grangeasse, C., Vaganay, E., Riberty, M., Cozzone, A. J., Doublet, P. (2000). "Relationship between exopolysaccharide production and protein-tyrosine phosphorylation in gram-negative bacteria." J Mol Biol 304:311-321. Pubmed: 11090276