ECMDB: Tyrosine-protein kinase etk (P38134)

Identification

Name:

Tyrosine-protein kinase etk

Synonyms:

Not Available

Gene Name:

etk

Enzyme Class:

Not Available

Biological Properties

General Function:

Cell wall/membrane/envelope biogenesis

Specific Function:

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Cellular Location:

Cell inner membrane; Multi-pass membrane protein.

SMPDB Pathways:

Not Available

KEGG Pathways:

Not Available

Complex Reactions:

1.0

1.0a [protein]-L-tyrosine

→

1.0

1.0a [protein]-L-tyrosine phosphate

1.0Adenosine triphosphate + 1.0a [protein]-L-tyrosine → 1.0ADP + 1.0a [protein]-L-tyrosine phosphate
ReactionCard

Metabolites:

ECMDB ID	Name	View
ECMDB00538	Adenosine triphosphate	MetaboCard
ECMDB01341	ADP	MetaboCard

GO Classification:

Component
cell part
membrane
Function
enzyme regulator activity
Process
capsule polysaccharide biosynthetic process
carbohydrate metabolic process
cellular polysaccharide biosynthetic process
extracellular polysaccharide biosynthetic process
lipid biosynthetic process
lipid metabolic process
lipopolysaccharide biosynthetic process
metabolic process
polysaccharide biosynthetic process
polysaccharide metabolic process
primary metabolic process

Gene Properties

Blattner:

Not Available

Gene Orientation

Not Available

Centisome Percentage:

Not Available

Left Sequence End

Not Available

Right Sequence End

Not Available

Gene Sequence:

>2181 bp
ATGACAACTAAAAATATGAATACGCCACCAGGCAGCACTCAGGAAAATGAGATCGATCTG
CTTCGTCTGGTCGGCGAGTTATGGGATCACCGTAAGTTTATTATCAGCGTGACCGCGTTA
TTCACGCTGATCGCTGTCGCTTACTCGCTGTTAAGCACACCAATTTATCAGGCAGATACT
CTGGTCCAGGTTGAGCAAAAACAGGGCAACGCCATTCTCAGCGGCCTGAGCGATATGATC
CCTAACTCATCGCCCGAGTCTGCACCGGAGATCCAACTGCTGCAATCGCGCATGATTCTC
GGTAAAACCATTGCTGAACTGAATCTGCGCGACATAGTTGAGCAGAAGTATTTTCCGATT
GTGGGTCGCGGCTGGGCGAGATTAACCAAAGAAAAACCAGGTGAGCTGGCGATCAGCTGG
ATGCATATTCCACAACTGAATGGTCAGGATCAGCAACTGACACTCACGGTTGGGGAAAAC
GGCCACTATACACTGGAAGGTGAAGAGTTCACCGTCAATGGTATGGTCGGCCAGCGTCTG
GAAAAAGATGGCGTTGCGCTGACTATCGCGGACATTAAGGCCAAACCAGGAACACAGTTT
GTCCTGAGCCAGCGTACCGAACTGGAAGCGATTAACGCATTGCAGGAAACCTTTACCGTT
AGCGAACGCAGTAAAGAAAGCGGGATGCTGGAACTTACCATGACTGGTGATGATCCCCAG
TTGATTACTCGTATTCTGAACAGCATCGCTAACAACTATTTGCAACAGAATATCGCTCGC
CAGGCGGCGCAGGATTCACAAAGCCTTGAATTCTTACAGCGCCAGTTACCTGAAGTGCGC
AGCGAGCTGGACCAAGCGGAAGAAAAACTCAACGTTTATCGCCAGCAGCGCGATTCGGTT
GACCTTAACCTGGAAGCCAAAGCCGTTCTTGAGCAGATTGTGAACGTTGATAATCAACTC
AATGAGCTGACCTTCCGCGAGGCAGAGATCTCCCAGCTGTATAAGAAAGATCACCCAACT
TATCGTGCGCTGCTGGAAAAACGCCAGACGCTGGAGCAAGAACGCAAACGCCTGAATAAG
CGGGTATCGGCAATGCCTTCCACCCAACAGGAAGTGTTGCGTTTAAGTCGTGACGTAGAA
GCGGGCCGTGCGGTATATCTGCAATTACTTAACCGCCAGCAGGAGTTGAGTATTTCGAAA
TCCAGTGCCATTGGTAACGTGCGGATTATCGACCCGGCAGTCACTCAGCCGCAGCCAGTG
AAACCGAAAAAAGCGTTGAACGTGGTGCTTGGTTTTATTCTTGGCCTGTTTATTTCTGTG
GGTGCCGTGCTGGCGCGTGCGATGTTGCGTCGTGGTGTAGAAGCCCCGGAACAACTGGAA
GAGCACGGCATCAGCGTTTATGCCACTATCCCAATGTCCGAGTGGCTGGATAAACGCACC
CGTCTGCGTAAGAAAAATTTATTTTCTAATCAGCAGCGCCATCGTACTAAAAATATCCCC
TTCCTGGCGGTGGATAACCCGGCGGATTCTGCTGTGGAAGCCGTACGTGCGCTACGAACC
AGTCTGCATTTCGCTATGATGGAGACGGAGAATAACATTCTAATGATCACCGGTGCGACG
CCAGACAGTGGTAAAACGTTTGTCAGTTCAACTCTGGCAGCGGTGATCGCCCAGTCCGAT
CAAAAAGTGTTATTTATTGATGCCGACTTACGCCGTGGTTATTCGCATAACCTGTTTACC
GTGAGTAATGAACATGGCTTGTCGGAATATCTGGCAGGTAAAGATGAGCTCAACAAAGTG
ATCCAGCATTTTGGCAAAGGAGGCTTTGATGTGATTACTCGCGGTCAGGTGCCACCTAAC
CCGTCTGAACTGCTGATGCGCGATCGGATGCGTCAATTACTGGAATGGGCGAACGACCAT
TACGATCTGGTGATTGTCGATACGCCGCCGATGCTGGCGGTGAGTGATGCCGCGGTCGTG
GGGCGTTCTGTTGGCACCAGCCTGCTGGTTGCGCGTTTTGGCTTGAACACCGCCAAAGAG
GTGAGTTTGTCAATGCAGCGTCTGGAACAGGCAGGCGTCAATATTAAAGGCGCTATCCTC
AATGGTGTGATTAAACGCGCCAGCACCGCTTACAGTTACGGCTATAACTATTACGGTTAT
AGTTACTCCGAGAAAGAGTAA

Protein Properties

Pfam Domain Function:

CbiA (PF01656 )
Wzz (PF02706 )

Protein Residues:

726

Protein Molecular Weight:

81241

Protein Theoretical pI:

Signaling Regions:

None

Transmembrane Regions:

33-53
425-445

Protein Sequence:

>Tyrosine-protein kinase etk
MTTKNMNTPPGSTQENEIDLLRLVGELWDHRKFIISVTALFTLIAVAYSLLSTPIYQADT
LVQVEQKQGNAILSGLSDMIPNSSPESAPEIQLLQSRMILGKTIAELNLRDIVEQKYFPI
VGRGWARLTKEKPGELAISWMHIPQLNGQDQQLTLTVGENGHYTLEGEEFTVNGMVGQRL
EKDGVALTIADIKAKPGTQFVLSQRTELEAINALQETFTVSERSKESGMLELTMTGDDPQ
LITRILNSIANNYLQQNIARQAAQDSQSLEFLQRQLPEVRSELDQAEEKLNVYRQQRDSV
DLNLEAKAVLEQIVNVDNQLNELTFREAEISQLYKKDHPTYRALLEKRQTLEQERKRLNK
RVSAMPSTQQEVLRLSRDVEAGRAVYLQLLNRQQELSISKSSAIGNVRIIDPAVTQPQPV
KPKKALNVVLGFILGLFISVGAVLARAMLRRGVEAPEQLEEHGISVYATIPMSEWLDKRT
RLRKKNLFSNQQRHRTKNIPFLAVDNPADSAVEAVRALRTSLHFAMMETENNILMITGAT
PDSGKTFVSSTLAAVIAQSDQKVLFIDADLRRGYSHNLFTVSNEHGLSEYLAGKDELNKV
IQHFGKGGFDVITRGQVPPNPSELLMRDRMRQLLEWANDHYDLVIVDTPPMLAVSDAAVV
GRSVGTSLLVARFGLNTAKEVSLSMQRLEQAGVNIKGAILNGVIKRASTAYSYGYNYYGY
SYSEKE

References

External Links:

Resource	Link
Uniprot ID:	P38134
Uniprot Name:	ETK_ECOLI
GenBank Gene ID:	U00096
Genebank Protein ID:	1787216
CCDB:	ETK_ECOLI

General Reference:

Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
Borodovsky, M., Rudd, K. E., Koonin, E. V. (1994). "Intrinsic and extrinsic approaches for detecting genes in a bacterial genome." Nucleic Acids Res 22:4756-4767. Pubmed: 7984428
Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
Dassa, J., Marck, C., Boquet, P. L. (1990). "The complete nucleotide sequence of the Escherichia coli gene appA reveals significant homology between pH 2.5 acid phosphatase and glucose-1-phosphatase." J Bacteriol 172:5497-5500. Pubmed: 2168385
Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
Oshima, T., Aiba, H., Baba, T., Fujita, K., Hayashi, K., Honjo, A., Ikemoto, K., Inada, T., Itoh, T., Kajihara, M., Kanai, K., Kashimoto, K., Kimura, S., Kitagawa, M., Makino, K., Masuda, S., Miki, T., Mizobuchi, K., Mori, H., Motomura, K., Nakamura, Y., Nashimoto, H., Nishio, Y., Saito, N., Horiuchi, T., et, a. l. .. (1996). "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." DNA Res 3:137-155. Pubmed: 8905232
Vincent, C., Duclos, B., Grangeasse, C., Vaganay, E., Riberty, M., Cozzone, A. J., Doublet, P. (2000). "Relationship between exopolysaccharide production and protein-tyrosine phosphorylation in gram-negative bacteria." J Mol Biol 304:311-321. Pubmed: 11090276