Cysteine/O-acetylserine efflux protein (P38101)

Identification
Name:Cysteine/O-acetylserine efflux protein
Synonyms:Not Available
Gene Name:eamB
Enzyme Class:Not Available
Biological Properties
General Function:Signal transduction mechanisms
Specific Function:Exporter of O-acetylserine (OAS) and cysteine
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Transports:
Transport References:
  • Orth, J. D., Conrad, T. M., Na, J., Lerman, J. A., Nam, H., Feist, A. M., Palsson, B. O. (2011). "A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011." Mol Syst Biol 7:535. Pubmed: 21988831
Metabolites:
ECMDB IDNameView
ECMDB00574L-CysteineMetaboCard
ECMDB03011O-AcetylserineMetaboCard
GO Classification:
Component
cell part
membrane
Process
amine transport
amino acid transport
establishment of localization
transport
Gene Properties
Blattner:b2578
Gene OrientationClockwise
Centisome Percentage:58.48
Left Sequence End2713445
Right Sequence End2714032
Gene Sequence:
>588 bp
ATGAATACTTTACGTATTGGCTTAGTTTCCATCTCTGATCGCGCATCCAGCGGCGTTTAT
CAGGATAAAGGCATCCCTGCGCTGGAAGAATGGCTGACATCGGCGCTAACCACGCCGTTT
GAACTGGAAACCCGCTTAATCCCCGATGAGCAGGCGATCATCGAGCAAACGTTGTGTGAG
CTGGTGGATGAAATGAGTTGCCATCTGGTGCTCACCACGGGCGGAACTGGCCCGGCGCGT
CGTGACGTAACGCCCGATGCGACGCTGGCAGTAGCGGACCGCGAGATGCCTGGCTTTGGT
GAACAGATGCGCCAGATCAGCCTGCATTTTGTACCAACTGCGATCCTTTCGCGTCAGGTG
GGCGTGATTCGCAAACAGGCGCTGATCCTTAACTTACCCGGTCAGCCGAAGTCTATTAAA
GAGACGCTGGAAGGTGTGAAGGACGCTGAGGGTAACGTTGTGGTACACGGTATTTTTGCC
AGCGTACCGTACTGCATTCAGTTGCTGGAAGGGCCATACGTTGAAACGGCACCGGAAGTG
GTTGCAGCATTCAGACCGAAGAGTGCAAGACGCGACGTTAGCGAATAA
Protein Properties
Pfam Domain Function:
Protein Residues:195
Protein Molecular Weight:21248
Protein Theoretical pI:10
Signaling Regions:
  • None
Transmembrane Regions:
  • 8-28
  • 47-67
  • 70-90
  • 105-125
  • 142-162
  • 177-194
Protein Sequence:
>Cysteine/O-acetylserine efflux protein
MTPTLLSAFWTYTLITAMTPGPNNILALSSATSHGFRQSTRVLAGMSLGFLIVMLLCAGI
SFSLAVIDPAAVHLLSWAGAAYIVWLAWKIATSPTKEDGLQAKPISFWASFALQFVNVKI
ILYGVTALSTFVLPQTQALSWVVGVSVLLAMIGTFGNVCWALAGHLFQRLFRQYGRQLNI
VLALLLVYCAVRIFY
References
External Links:
ResourceLink
Uniprot ID:P38101
Uniprot Name:EAMB_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674278
Ecogene ID:EG12445
Ecocyc:EG12445
ColiBase:b2578
Kegg Gene:b2578
EchoBASE ID:EB2339
CCDB:EAMB_ECOLI
BacMap:16130503
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Franke, I., Resch, A., Dassler, T., Maier, T., Bock, A. (2003). "YfiK from Escherichia coli promotes export of O-acetylserine and cysteine." J Bacteriol 185:1161-1166. Pubmed: 12562784
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Yamamoto, Y., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Itoh, T., Kimura, S., Kitagawa, M., Makino, K., Miki, T., Mitsuhashi, N., Mizobuchi, K., Mori, H., Nakade, S., Nakamura, Y., Nashimoto, H., Oshima, T., Oyama, S., Saito, N., Sampei, G., Satoh, Y., Sivasundaram, S., Tagami, H., Horiuchi, T., et, a. l. .. (1997). "Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features." DNA Res 4:91-113. Pubmed: 9205837