dTDP-4-dehydrorhamnose 3,5-epimerase (P37745)

Identification
Name:dTDP-4-dehydrorhamnose 3,5-epimerase
Synonyms:
  • Thymidine diphospho-4-keto-rhamnose 3,5-epimerase
  • dTDP-4-keto-6-deoxyglucose 3,5-epimerase
  • dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase
  • dTDP-L-rhamnose synthase
Gene Name:rfbC
Enzyme Class:
Biological Properties
General Function:Involved in dTDP-4-dehydrorhamnose 3,5-epimerase activity
Specific Function:Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
KEGG Reactions:
1.0Thumb ↔ 1.0Thumb
1.04,6-Dideoxy-4-oxo-dTDP-D-glucose ↔ 1.0dTDP-4-Dehydro-6-deoxy-L-mannose
ReactionCard
SMPDB Reactions:
1.0dTDP-4-dehydro-6-deoxy-D-glucose → 1.0dTDP-4-dehydro-beta-L-rhamnose
1.0dTDP-4-dehydro-6-deoxy-D-glucose → 1.0dTDP-4-dehydro-beta-L-rhamnose
ReactionCard
EcoCyc Reactions:
1.0Thumb ↔ 1.0dTDP-4-dehydro-6-deoxy-β-L-mannose
1.04,6-Dideoxy-4-oxo-dTDP-D-glucose ↔ 1.0dTDP-4-dehydro-6-deoxy-β-L-mannose
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB013994,6-Dideoxy-4-oxo-dTDP-D-glucoseMetaboCard
ECMDB21327dTDP-4-Dehydro-6-deoxy-L-mannoseMetaboCard
GO Classification:
Function
catalytic activity
dTDP-4-dehydrorhamnose 3,5-epimerase activity
isomerase activity
racemase and epimerase activity
racemase and epimerase activity, acting on carbohydrates and derivatives
Process
lipid biosynthetic process
lipid metabolic process
lipopolysaccharide biosynthetic process
metabolic process
primary metabolic process
Gene Properties
Blattner:b2038
Gene OrientationCounterclockwise
Centisome Percentage:45.43
Left Sequence End2107605
Right Sequence End2108162
Gene Sequence:
>558 bp
GTGATTAGCGATATCAGAAAAGATGCTGAAGTACGCATGGACAAATGCGTAGAAGCGTTC
AAAACCCAAATCAGCAAAATACGCACGGGTCGTGCTTCTCCCAGCCTGCTGGATGGCATT
GTCGTGGAATATTACGGCACGCCGACGCCGCTGCGTCAGCTGGCAAGCGTAACGGTAGAA
GATTCCCGTACACTGAAAATCAACGTGTTTGATCGTTCAATGTCTCCGGCCGTTGAAAAA
GCGATTATGGCGTCCGATCTTGGCCTGAACCCGAACTCTGCGGGTAGCGACATCCGTGTT
CCGCTGCCGCCGCTGACGGAAGAACGTCGTAAAGATCTGACCAAAATCGTTCGTGGTGAA
GCAGAACAAGCGCGTGTTGCAGTACGTAACGTGCGTCGTGACGCGAACGACAAAGTGAAA
GCACTGTTGAAAGATAAAGAGATCAGCGAAGACGACGATCGCCGTTCTCAGGACGATGTA
CAGAAACTGACTGATGCTGCAATCAAGAAAATTGAAGCGGCGCTGGCAGACAAAGAAGCA
GAACTGATGCAGTTCTGA
Protein Properties
Pfam Domain Function:
Protein Residues:185
Protein Molecular Weight:21270
Protein Theoretical pI:6
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>dTDP-4-dehydrorhamnose 3,5-epimerase
MNVIRTEIEDVLILEPRVFGDDRGFFYESFNQSAFEHILGYPVSFVQDNHSRSSKNVLRG
LHFQRGEYAQDKLVRCTHGAVFDVAVDIRPNSVSFGKWVGVLLSADNKQQLWIPKGFAHG
FLVLSDIAEFQYKTTNYYHPESDCGICWNDERIAIDWPQTSGLILSPKDERLFTLDELIR
LKLIA
References
External Links:
ResourceLink
Uniprot ID:P37745
Uniprot Name:RMLC_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:21239027
Ecogene ID:EG11979
Ecocyc:EG11979
ColiBase:b2038
Kegg Gene:b2038
EchoBASE ID:EB1922
CCDB:RMLC_ECOLI
BacMap:16129978
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Itoh, T., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Kasai, H., Kimura, S., Kitakawa, M., Kitagawa, M., Makino, K., Miki, T., Mizobuchi, K., Mori, H., Mori, T., Motomura, K., Nakade, S., Nakamura, Y., Nashimoto, H., Nishio, Y., Oshima, T., Saito, N., Sampei, G., Seki, Y., Horiuchi, T., et, a. l. .. (1996). "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map." DNA Res 3:379-392. Pubmed: 9097040
  • Stevenson, G., Neal, B., Liu, D., Hobbs, M., Packer, N. H., Batley, M., Redmond, J. W., Lindquist, L., Reeves, P. (1994). "Structure of the O antigen of Escherichia coli K-12 and the sequence of its rfb gene cluster." J Bacteriol 176:4144-4156. Pubmed: 7517391
  • Yao, Z., Valvano, M. A. (1994). "Genetic analysis of the O-specific lipopolysaccharide biosynthesis region (rfb) of Escherichia coli K-12 W3110: identification of genes that confer group 6 specificity to Shigella flexneri serotypes Y and 4a." J Bacteriol 176:4133-4143. Pubmed: 7517390