3-keto-L-gulonate-6-phosphate decarboxylase sgbH (P37678)

Identification
Name:3-keto-L-gulonate-6-phosphate decarboxylase sgbH
Synonyms:
  • KGPDC
  • 3-dehydro-L-gulonate-6-phosphate decarboxylase
Gene Name:sgbH
Enzyme Class:
Biological Properties
General Function:Involved in catalytic activity
Specific Function:Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. May be involved in the utilization of 2,3- diketo-L-gulonate
Cellular Location:Not Available
SMPDB Pathways:
KEGG Pathways:
  • Ascorbate and aldarate metabolism ec00053
  • Metabolic pathways eco01100
  • Microbial metabolism in diverse environments ec01120
  • Pentose and glucuronate interconversions ec00040
KEGG Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.03-Dehydro-L-gulonate 6-phosphate + 1.0Hydrogen ion ↔ 1.0Carbon dioxide + 1.0L-Xylulose 5-phosphate
ReactionCard
SMPDB Reactions:
1.02,3-Diketo-L-gulonate+1.0Thumb+1.0Thumb → 1.0Thumb+1.0Xylulose 5-phosphate+1.0Thumb
1.02,3-Diketo-L-gulonate + 1.0Hydrogen ion + 1.02,3-Diketo-L-gulonate → 1.0Carbon dioxide + 1.0Xylulose 5-phosphate + 1.0Xylulose 5-phosphate
ReactionCard
1.03-keto-L-gulonate 6-phosphate+1.0Thumb+1.0Thumb → 1.0L-xylulose -5-phosphate+1.0Thumb+1.0Thumb
1.03-keto-L-gulonate 6-phosphate + 1.0Hydrogen ion + 1.03-Keto-L-gulonate 6-phosphate → 1.0L-xylulose -5-phosphate + 1.0Carbon dioxide + 1.0L-Xylulose 5-phosphate
ReactionCard
1.03-keto-L-gulonate 6-phosphate+1.0Thumb → 1.0L-xylulose -5-phosphate+1.0Thumb
1.03-keto-L-gulonate 6-phosphate + 1.03-Keto-L-gulonate 6-phosphate → 1.0L-xylulose -5-phosphate + 1.0L-Xylulose 5-phosphate
ReactionCard
EcoCyc Reactions:
1.0Thumb+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.03-Dehydro-L-gulonate 6-phosphate + 1.0Hydrogen ion ↔ 1.0Carbon dioxide + 1.0L-Xylulose 5-phosphate
ReactionCard
1.0Thumb+1.0Thumb → 1.0Thumb+1.0Thumb
1.0Hydrogen ion + 1.03-Dehydro-L-gulonate 6-phosphate → 1.0L-Xylulose 5-phosphate + 1.0Carbon dioxide
ReactionCard
Complex Reactions:
1.0Thumb → 1.0Thumb+1.0Thumb
1.03-Dehydro-L-gulonate 6-phosphate → 1.0L-Xylulose 5-phosphate + 1.0Carbon dioxide
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB065112,3-Diketo-L-gulonateMetaboCard
ECMDB200673-Dehydro-L-gulonate 6-phosphateMetaboCard
ECMDB202713-Keto-L-gulonate 6-phosphateMetaboCard
ECMDB04030Carbon dioxideMetaboCard
ECMDB21225Hydrogen ionMetaboCard
ECMDB20169L-Xylulose 5-phosphateMetaboCard
ECMDB04178Xylulose 5-phosphateMetaboCard
GO Classification:
Function
carbon-carbon lyase activity
carboxy-lyase activity
catalytic activity
lyase activity
orotidine-5'-phosphate decarboxylase activity
Process
'de novo' pyrimidine base biosynthetic process
cellular aromatic compound metabolic process
cellular metabolic process
metabolic process
nucleobase metabolic process
pyrimidine base biosynthetic process
pyrimidine base metabolic process
Gene Properties
Blattner:b3581
Gene OrientationClockwise
Centisome Percentage:80.75
Left Sequence End3746600
Right Sequence End3747262
Gene Sequence:
>663 bp
ATGGAACTGTATCTGGATACTTCAGACGTTGTTGCGGTGAAGGCGCTGTCACGTATTTTT
CCGCTGGCGGGTGTGACCACTAACCCAAGCATTATCGCCGCGGGTAAAAAACCGCTGGAT
GTTGTGCTTCCGCAACTTCATGAAGCGATGGGCGGTCAGGGGCGTCTGTTTGCCCAGGTA
ATGGCTACCACTGCCGAAGGGATGGTTAATGACGCGCTTAAGCTGCGTTCTATTATTGCG
GATATCGTGGTGAAAGTTCCGGTGACCGCCGAGGGGCTGGCAGCTATTAAGATGTTAAAA
GCGGAAGGGATTCCGACGCTGGGAACCGCGGTATATGGCGCAGCACAAGGGCTGCTGTCG
GCGCTGGCAGGTGCGGAATATGTTGCGCCTTACGTTAATCGTATTGATGCTCAGGGCGGT
AGCGGCATTCAGACTGTGACCGACTTACACCAGTTATTGAAAATGCATGCGCCGCAGGCG
AAAGTGCTGGCAGCGAGTTTCAAAACCCCGCGTCAGGCGCTGGACTGCTTACTGGCAGGA
TGTGAATCAATTACTCTGCCACTGGATGTGGCACAACAGATGATTAGCTATCCGGCGGTT
GATGCCGCTGTGGCGAAGTTTGAGCAGGACTGGCAGGGAGCGTTTGGCAGAACGTCGATT
TAA
Protein Properties
Pfam Domain Function:
Protein Residues:220
Protein Molecular Weight:23445
Protein Theoretical pI:5
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>3-keto-L-gulonate-6-phosphate decarboxylase sgbH
MSRPLLQLALDHSSLEAAQRDVTLLKDSVDIVEAGTILCLNEGLGAVKALREQCPDKIIV
ADWKVADAGETLAQQAFGAGANWMTIICAAPLATVEKGHAMAQRCGGEIQIELFGNWTLD
DARDWHRIGVRQAIYHRGRDAQASGQQWGEADLARMKALSDIGLELSITGGITPADLPLF
KDIRVKAFIAGRALAGAANPAQVAGDFHAQIDAIWGGARA
References
External Links:
ResourceLink
Uniprot ID:P37678
Uniprot Name:SGBH_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674771
Ecogene ID:EG12285
Ecocyc:EG12285
ColiBase:b3581
Kegg Gene:b3581
EchoBASE ID:EB2193
CCDB:SGBH_ECOLI
BacMap:16131452
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Reizer, J., Reizer, A., Saier, M. H. Jr (1997). "Is the ribulose monophosphate pathway widely distributed in bacteria?" Microbiology 143 ( Pt 8):2519-2520. Pubmed: 9274005
  • Sofia, H. J., Burland, V., Daniels, D. L., Plunkett, G. 3rd, Blattner, F. R. (1994). "Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes." Nucleic Acids Res 22:2576-2586. Pubmed: 8041620
  • Yew, W. S., Gerlt, J. A. (2002). "Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operons." J Bacteriol 184:302-306. Pubmed: 11741871