Quinone oxidoreductase 1 (P28304)

Identification
Name:Quinone oxidoreductase 1
Synonyms:
  • NADPH:quinone reductase 1
  • Zeta-crystallin homolog protein
Gene Name:qorA
Enzyme Class:
Biological Properties
General Function:Involved in zinc ion binding
Specific Function:NADPH + 2 quinone = NADP(+) + 2 semiquinone
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
KEGG Reactions:
1.0Thumb+1.0Thumb+2.0Thumb ↔ 1.0Thumb+2.0Thumb
1.0NADPH + 1.0Hydrogen ion + 2.0Quinone ↔ 1.0NADP + 2.0Semiquinone
ReactionCard
Complex Reactions:
1.0Thumb+2.0Thumb → 1.0Thumb+2.0semiquinone
1.0NADPH + 2.0Quinone → 1.0NADP + 2.0semiquinone
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB00217NADPMetaboCard
ECMDB04111NADPHMetaboCard
ECMDB23060QuinoneMetaboCard
GO Classification:
Function
binding
catalytic activity
cation binding
ion binding
metal ion binding
oxidoreductase activity
transition metal ion binding
zinc ion binding
Process
metabolic process
oxidation reduction
Gene Properties
Blattner:b4051
Gene OrientationCounterclockwise
Centisome Percentage:91.84
Left Sequence End4261271
Right Sequence End4262254
Gene Sequence:
>984 bp
GTGGAAGCGATTAAGGGATCGGACGTTAATGTCCCGGATGCAGTATTTGCCTGGATGCTG
GATGGTAGAGGCGGCGTTAAACCGCTGGAAAATACAGATGTGATTGATGAAGCGCATCCC
TGTTGGCTCCACCTTAATTATGTACACCATGATAGCGCCCAATGGCTGGCGACAACACCG
CTGCTTCCCAATAACGTACGTGATGCGCTGGCGGGCGAGAGCACGCGTCCCCGAGTCAGC
CGTCTCGGTGAAGGCACGCTGATTACATTGCGCTGTATAAACGGCAGCACCGATGAACGC
CCCGATCAACTGGTCGCCATGCGTGTATATATGGACGGGCGGTTAATTGTTTCGACCCGA
CAACGCAAAGTGCTGGCGCTGGACGATGTGGTGAGCGATCTGGAAGAGGGCACGGGTCCG
ACCGATTGCGGGGGATGGCTGGTGGATGTGTGCGATGCGTTGACCGATCATTCCAGTGAA
TTTATCGAGCAGCTGCACGATAAAATTATCGACCTTGAAGATAATCTCCTTGATCAGCAA
ATTCCACCGCGTGGATTCCTGGCTCTGCTGCGCAAACAATTAATTGTGATGCGTCGCTAT
ATGGCACCGCAACGTGATGTTTATGCTCGTCTTGCCAGTGAACGTTTGCCGTGGATGAGC
GATGACCAACGCCGTCGGATGCAGGATATTGCCGATCGCCTTGGGCGCGGCCTTGACGAA
ATCGACGCCTGTATAGCACGGACTGGCGTGATGGCGGATGAAATCGCTCAGGTGATGCAG
GAAAATTTAGCTCGTCGTACCTATACAATGTCGTTGATGGCAATGGTCTTTTTACCCAGT
ACCTTTCTGACCGGGTTATTTGGCGTCAACCTTGGTGGGATCCCTGGCGGCGGGTGGCAA
TTCGGATTTTCAATTTTTTGTATTCTGTTAGTTGTTCTTATTGGTGGTGTTGCTTTATGG
TTGCATCGTAGTAAATGGTTGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:327
Protein Molecular Weight:35172
Protein Theoretical pI:9
PDB File:1QOR
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Quinone oxidoreductase 1
MATRIEFHKHGGPEVLQAVEFTPADPAENEIQVENKAIGINFIDTYIRSGLYPPPSLPSG
LGTEAAGIVSKVGSGVKHIKAGDRVVYAQSALGAYSSVHNIIADKAAILPAAISFEQAAA
SFLKGLTVYYLLRKTYEIKPDEQFLFHAAAGGVGLIACQWAKALGAKLIGTVGTAQKAQS
ALKAGAWQVINYREEDLVERLKEITGGKKVRVVYDSVGRDTWERSLDCLQRRGLMVSFGN
SSGAVTGVNLGILNQKGSLYVTRPSLQGYITTREELTEASNELFSLIASGVIKVDVAEQQ
KYPLKDAQRAHEILESRATQGSSLLIP
References
External Links:
ResourceLink
Uniprot ID:P28304
Uniprot Name:QOR1_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85674915
PDB ID:1QOR
Ecogene ID:EG11492
Ecocyc:EG11492
ColiBase:b4051
Kegg Gene:b4051
EchoBASE ID:EB1455
CCDB:QOR1_ECOLI
BacMap:16131877
General Reference:
  • Blattner, F. R., Burland, V., Plunkett, G. 3rd, Sofia, H. J., Daniels, D. L. (1993). "Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes." Nucleic Acids Res 21:5408-5417. Pubmed: 8265357
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Thorn, J. M., Barton, J. D., Dixon, N. E., Ollis, D. L., Edwards, K. J. (1995). "Crystal structure of Escherichia coli QOR quinone oxidoreductase complexed with NADPH." J Mol Biol 249:785-799. Pubmed: 7602590