| Identification |
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| Name: | Low affinity tryptophan permease |
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| Synonyms: | Not Available |
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| Gene Name: | tnaB |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | Involved in amino acid transmembrane transporter activity |
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| Specific Function: | Involved in tryptophan transport across the cytoplasmic membrane. Plays a role in transporting tryptophan which is to be used catabolically |
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| Cellular Location: | Cell inner membrane; Multi-pass membrane protein |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Transports: | |
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| Transport References: | - Orth, J. D., Conrad, T. M., Na, J., Lerman, J. A., Nam, H., Feist, A. M., Palsson, B. O. (2011). "A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011." Mol Syst Biol 7:535. Pubmed: 21988831
- Uniprot Consortium (2012). "Reorganizing the protein space at the Universal Protein Resource (UniProt)." Nucleic Acids Res 40:D71-D75. Pubmed: 22102590
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| Metabolites: | |
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| GO Classification: | | Component |
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| cell part | | integral to membrane | | integral to plasma membrane | | intrinsic to membrane | | membrane | | membrane part | | Function |
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| active transmembrane transporter activity | | amine transmembrane transporter activity | | amino acid transmembrane transporter activity | | aromatic amino acid transmembrane transporter activity | | transmembrane transporter activity | | transporter activity | | Process |
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| amine transport | | amino acid transport | | aromatic amino acid transport | | establishment of localization | | transport |
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| Gene Properties |
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| Blattner: | b3709 |
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| Gene Orientation | Clockwise |
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| Centisome Percentage: | 83.80 |
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| Left Sequence End | 3888259 |
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| Right Sequence End | 3889506 |
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| Gene Sequence: | >1248 bp
ATGACTGATCAAGCTGAAAAAAAGCACTCTGCATTTTGGGGTGTTATGGTTATAGCAGGT
ACAGTAATTGGTGGAGGTATGTTTGCTTTACCTGTTGATCTTGCCGGTGCCTGGTTTTTC
TGGGGTGCCTTTATCCTTATCATTGCCTGGTTTTCAATGCTTCATTCCGGGTTATTGTTA
TTAGAAGCAAATTTAAATTATCCCGTCGGCTCCAGTTTTAACACCATCACCAAAGATTTA
ATCGGTAACACCTGGAACATTATCAGCGGTATTACCGTTGCCTTCGTTCTCTATATCCTC
ACTTATGCCTATATCTCTGCTAATGGTGCGATCATTAGTGAAACGATATCAATGAATTTG
GGTTATCACGCTAATCCACGTATTGTCGGGATCTGCACAGCCATTTTCGTTGCCAGCGTA
TTGTGGTTAAGTTCGTTAGCCGCCAGTCGTATTACCTCATTGTTCCTCGGGCTGAAGATT
ATCTCCTTTGTGATCGTGTTTGGTTCTTTTTTCTTCCAGGTCGATTACTCCATTCTGCGC
GACGCCACCAGCTCCACTGCGGGAACGTCTTACTTCCCGTATATCTTTATGGCTTTGCCG
GTGTGTCTGGCGTCATTTGGTTTCCACGGCAATATTCCCAGCCTGATTATTTGCTATGGA
AAACGCAAAGATAAGTTAATCAAAAGCGTGGTATTTGGTTCGCTGCTGGCGCTGGTGATT
TATCTCTTCTGGCTCTATTGCACCATGGGGAATATTCCGCGAGAAAGCTTTAAGGCGATT
ATCTCCTCAGGCGGCAACGTTGATTCGCTGGTGAAATCGTTCCTCGGCACCAAACAGCAC
GGCATTATCGAGTTTTGCCTGCTGGTGTTCTCTAACTTAGCTGTTGCCAGTTCGTTCTTT
GGTGTCACGCTGGGGTTGTTCGATTATCTGGCGGACCTGTTTAAGATTGATAACTCCCAC
GGCGGGCGTTTCAAAACCGTGCTGTTAACCTTCCTGCCACCTGCGTTGTTGTATCTGATC
TTCCCGAACGGCTTTATTTACGGGATCGGCGGTGCCGGGCTGTGCGCCACCATCTGGGCG
GTCATTATTCCCGCAGTGCTTGCAATCAAAGCTCGCAAGAAGTTTCCCAATCAGATGTTC
ACGGTCTGGGGCGGCAATCTTATTCCGGCGATTGTCATTCTCTTTGGTATAACCGTGATT
TTGTGCTGGTTCGGCAACGTCTTTAACGTGTTACCTAAATTTGGCTAA |
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| Protein Properties |
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| Pfam Domain Function: | |
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| Protein Residues: | 415 |
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| Protein Molecular Weight: | 45210 |
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| Protein Theoretical pI: | 9 |
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| Signaling Regions: | |
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| Transmembrane Regions: | - 12-32
- 34-54
- 87-107
- 128-148
- 154-174
- 192-212
- 230-250
- 287-307
- 327-347
- 349-369
- 388-408
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| Protein Sequence: | >Low affinity tryptophan permease
MTDQAEKKHSAFWGVMVIAGTVIGGGMFALPVDLAGAWFFWGAFILIIAWFSMLHSGLLL
LEANLNYPVGSSFNTITKDLIGNTWNIISGITVAFVLYILTYAYISANGAIISETISMNL
GYHANPRIVGICTAIFVASVLWLSSLAASRITSLFLGLKIISFVIVFGSFFFQVDYSILR
DATSSTAGTSYFPYIFMALPVCLASFGFHGNIPSLIICYGKRKDKLIKSVVFGSLLALVI
YLFWLYCTMGNIPRESFKAIISSGGNVDSLVKSFLGTKQHGIIEFCLLVFSNLAVASSFF
GVTLGLFDYLADLFKIDNSHGGRFKTVLLTFLPPALLYLIFPNGFIYGIGGAGLCATIWA
VIIPAVLAIKARKKFPNQMFTVWGGNLIPAIVILFGITVILCWFGNVFNVLPKFG |
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| References |
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| External Links: | |
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| General Reference: | - Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Burland, V., Plunkett, G. 3rd, Daniels, D. L., Blattner, F. R. (1993). "DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication." Genomics 16:551-561. Pubmed: 7686882
- Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
- Deeley, M. C., Yanofsky, C. (1981). "Nucleotide sequence of the structural gene for tryptophanase of Escherichia coli K-12." J Bacteriol 147:787-796. Pubmed: 6268608
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
- Sarsero, J. P., Wookey, P. J., Gollnick, P., Yanofsky, C., Pittard, A. J. (1991). "A new family of integral membrane proteins involved in transport of aromatic amino acids in Escherichia coli." J Bacteriol 173:3231-3234. Pubmed: 2022620
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