Fe(3+) dicitrate transport protein fecA (P13036)

Identification
Name:Fe(3+) dicitrate transport protein fecA
Synonyms:
  • Iron(III) dicitrate transport protein fecA
Gene Name:fecA
Enzyme Class:Not Available
Biological Properties
General Function:Involved in receptor activity
Specific Function:FecA is the outer membrane receptor protein in the Fe(3+) dicitrate transport system
Cellular Location:Cell outer membrane
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Transports:
Transport References:
  • Orth, J. D., Conrad, T. M., Na, J., Lerman, J. A., Nam, H., Feist, A. M., Palsson, B. O. (2011). "A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011." Mol Syst Biol 7:535. Pubmed: 21988831
Metabolites:
ECMDB IDNameView
ECMDB21213Fe(III)dicitrateMetaboCard
ECMDB21225Hydrogen ionMetaboCard
GO Classification:
Component
cell part
membrane
outer membrane
Function
binding
cation binding
cation transmembrane transporter activity
di-, tri-valent inorganic cation transmembrane transporter activity
inorganic cation transmembrane transporter activity
ion binding
ion transmembrane transporter activity
iron ion binding
iron ion transmembrane transporter activity
metal ion binding
molecular transducer activity
receptor activity
siderophore-iron transmembrane transporter activity
signal transducer activity
substrate-specific transmembrane transporter activity
transition metal ion binding
transmembrane transporter activity
transporter activity
Process
establishment of localization
siderophore transport
transport
Gene Properties
Blattner:b4291
Gene OrientationCounterclockwise
Centisome Percentage:97.26
Left Sequence End4512376
Right Sequence End4514700
Gene Sequence:
>2325 bp
ATGACGCCGTTACGCGTTTTTCGTAAAACAACACCTTTGGTTAACACCATTCGCCTGAGC
CTGCTGCCGCTGGCCGGTCTCTCGTTTTCCGCTTTTGCTGCACAGGTTAATATCGCACCG
GGATCGCTCGATAAAGCGCTCAATCAGTATGCCGCACACAGCGGATTTACCCTCTCGGTT
GACGCCAGCCTGACGCGCGGCAAGCAGAGCAACGGCCTGCACGGCGATTACGACGTCGAG
AGCGGCCTGCAACAACTGCTGGACGGCAGCGGACTGCAGGTAAAACCGCTGGGAAATAAC
AGCTGGACGCTGGAGCCCGCGCCCGCACCAAAAGAAGATGCCCTGACCGTGGTCGGCGAC
TGGCTGGGTGATGCGCGTGAAAACGACGTATTTGAACATGCTGGCGCGCGTGACGTGATC
CGCCGTGAGGATTTCGCCAAAACCGGCGCAACCACCATGCGTGAGGTACTTAACCGCATC
CCTGGCGTCAGCGCGCCGGAAAACAACGGCACCGGCAGCCACGACCTGGCGATGAACTTT
GGCATCCGGGGCCTGAACCCGCGCCTCGCCAGCCGCTCGACCGTCCTGATGGACGGCATC
CCCGTCCCCTTCGCCCCTTACGGTCAGCCGCAGCTTTCACTGGCTCCCGTTTCGCTCGGC
AACATGGATGCCATTGACGTGGTACGCGGTGGTGGTGCGGTGCGTTACGGACCGCAGAGC
GTGGGCGGCGTGGTGAACTTTGTTACCCGTGCCATTCCGCAGGACTTTGGTATCGAGGCG
GGCGTGGAAGGTCAGCTCAGCCCAACCTCTTCACAAAACAACCCGAAAGAGACGCACAAC
CTGATGGTGGGCGGCACAGCGGACAACGGTTTTGGCACCGCGCTGCTCTACTCCGGCACG
CGCGGCAGTGACTGGCGCGAGCACAGCGCCACCCGCATCGACGACCTGATGCTGAAAAGC
AAATATGCGCCGGATGAGGTGCACACCTTCAACAGCCTGCTGCAATATTACGACGGTGAA
GCCGACATGCCCGGTGGCCTGTCTCGCGCGGATTACGACGCCGATCGCTGGCAATCCACC
CGCCCGTATGACCGCTTCTGGGGTCGTCGCAAGCTGGCGAGCCTGGGCTACCAGTTCCAG
CCAGACAGCCAGCATAAATTCAACATTCAGGGGTTCTACACCCAAACCCTGCGCAGCGGC
TACCTGGAGCAAGGCAAACGCATCACCCTCTCGCCGCGTAACTACTGGGTGCGCGGTATT
GAGCCACGCTACAGCCAGATCTTTATGATCGGCCCTTCCGCGCACGAAGTGGGCGTGGGC
TATCGCTATTTGAATGAATCAACGCATGAAATGCGTTACTACACCGCCACCAGCAGCGGG
CAGTTGCCGTCCGGCTCAAGCCCTTACGACCGCGATACGCGTTCCGGCACCGAGGCGCAC
GCCTGGTATCTGGATGACAAAATCGACATCGGCAACTGGACCATCACGCCGGGTATGCGT
TTCGAACATATCGAGTCATACCAGAACAACGCCATCACAGGCACGCACGAAGAAGTGAGC
TATAACGCACCGCTTCCGGCGTTGAACGTGCTCTATCACCTGACTGACAGCTGGAATCTT
TATGCAAACACTGAAGGCTCGTTCGGCACCGTACAGTACAGCCAGATTGGCAAGGCTGTG
CAAAGCGGCAATGTTGAACCGGAAAAAGCGCGAACCTGGGAACTCGGTACCCGCTACGAC
GACGGCGCGCTGACGGCGGAAATGGGGCTGTTCCTGATTAACTTTAACAATCAGTACGAC
TCCAACCAGACCAACGACACCGTCACTGCACGTGGCAAAACGCGCCATACCGGGCTGGAA
ACGCAGGCACGTTACGATCTGGGTACGCTAACGCCAACGCTTGATAACGTTTCCATCTAC
GCCAGCTATGCGTATGTGAACGCGGAAATCCGCGAGAAAGGCGACACCTACGGCAATCTG
GTACCATTCTCCCCGAAACATAAAGGCACGCTGGGCGTGGACTACAAGCCAGGAAACTGG
ACGTTCAATCTGAACAGCGATTTCCAGTCCAGCCAGTTTGCGGATAACGCCAATACGGTG
AAAGAGAGCGCCGACGGCAGTACCGGCCGCATTCCCGGCTTCATGCTCTGGGGCGCACGC
GTGGCGTATGACTTTGGCCCGCAGATGGCAGATCTGAACCTGGCATTCGGTGTGAAAAAC
ATCTTCGACCAGGACTACTTCATCCGCTCTTATGACGACAACAACAAAGGCATCTATGCA
GGCCAGCCGCGCACGCTGTATATGCAGGGGTCGTTGAAGTTCTGA
Protein Properties
Pfam Domain Function:
Protein Residues:774
Protein Molecular Weight:85321
Protein Theoretical pI:6
PDB File:1KMO
Signaling Regions:
  • 1-33
Transmembrane Regions:
  • None
Protein Sequence:
>Fe(3+) dicitrate transport protein fecA
MTPLRVFRKTTPLVNTIRLSLLPLAGLSFSAFAAQVNIAPGSLDKALNQYAAHSGFTLSV
DASLTRGKQSNGLHGDYDVESGLQQLLDGSGLQVKPLGNNSWTLEPAPAPKEDALTVVGD
WLGDARENDVFEHAGARDVIRREDFAKTGATTMREVLNRIPGVSAPENNGTGSHDLAMNF
GIRGLNPRLASRSTVLMDGIPVPFAPYGQPQLSLAPVSLGNMDAIDVVRGGGAVRYGPQS
VGGVVNFVTRAIPQDFGIEAGVEGQLSPTSSQNNPKETHNLMVGGTADNGFGTALLYSGT
RGSDWREHSATRIDDLMLKSKYAPDEVHTFNSLLQYYDGEADMPGGLSRADYDADRWQST
RPYDRFWGRRKLASLGYQFQPDSQHKFNIQGFYTQTLRSGYLEQGKRITLSPRNYWVRGI
EPRYSQIFMIGPSAHEVGVGYRYLNESTHEMRYYTATSSGQLPSGSSPYDRDTRSGTEAH
AWYLDDKIDIGNWTITPGMRFEHIESYQNNAITGTHEEVSYNAPLPALNVLYHLTDSWNL
YANTEGSFGTVQYSQIGKAVQSGNVEPEKARTWELGTRYDDGALTAEMGLFLINFNNQYD
SNQTNDTVTARGKTRHTGLETQARYDLGTLTPTLDNVSIYASYAYVNAEIREKGDTYGNL
VPFSPKHKGTLGVDYKPGNWTFNLNSDFQSSQFADNANTVKESADGSTGRIPGFMLWGAR
VAYDFGPQMADLNLAFGVKNIFDQDYFIRSYDDNNKGIYAGQPRTLYMQGSLKF
References
External Links:
ResourceLink
Uniprot ID:P13036
Uniprot Name:FECA_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85677032
PDB ID:1KMO
Ecogene ID:EG10286
Ecocyc:EG10286
ColiBase:b4291
Kegg Gene:b4291
EchoBASE ID:EB0282
CCDB:FECA_ECOLI
BacMap:16132112
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Burland, V., Plunkett, G. 3rd, Sofia, H. J., Daniels, D. L., Blattner, F. R. (1995). "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Nucleic Acids Res 23:2105-2119. Pubmed: 7610040
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Pressler, U., Staudenmaier, H., Zimmermann, L., Braun, V. (1988). "Genetics of the iron dicitrate transport system of Escherichia coli." J Bacteriol 170:2716-2724. Pubmed: 2836368
  • Staudenmaier, H., Van Hove, B., Yaraghi, Z., Braun, V. (1989). "Nucleotide sequences of the fecBCDE genes and locations of the proteins suggest a periplasmic-binding-protein-dependent transport mechanism for iron(III) dicitrate in Escherichia coli." J Bacteriol 171:2626-2633. Pubmed: 2651410
  • Van Hove, B., Staudenmaier, H., Braun, V. (1990). "Novel two-component transmembrane transcription control: regulation of iron dicitrate transport in Escherichia coli K-12." J Bacteriol 172:6749-6758. Pubmed: 2254251