| Identification |
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| Name: | Fe(3+) dicitrate transport protein fecA |
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| Synonyms: | - Iron(III) dicitrate transport protein fecA
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| Gene Name: | fecA |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | Involved in receptor activity |
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| Specific Function: | FecA is the outer membrane receptor protein in the Fe(3+) dicitrate transport system |
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| Cellular Location: | Cell outer membrane |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Transports: | |
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| Transport References: | - Orth, J. D., Conrad, T. M., Na, J., Lerman, J. A., Nam, H., Feist, A. M., Palsson, B. O. (2011). "A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011." Mol Syst Biol 7:535. Pubmed: 21988831
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| Metabolites: | |
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| GO Classification: | | Component |
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| cell part | | membrane | | outer membrane | | Function |
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| binding | | cation binding | | cation transmembrane transporter activity | | di-, tri-valent inorganic cation transmembrane transporter activity | | inorganic cation transmembrane transporter activity | | ion binding | | ion transmembrane transporter activity | | iron ion binding | | iron ion transmembrane transporter activity | | metal ion binding | | molecular transducer activity | | receptor activity | | siderophore-iron transmembrane transporter activity | | signal transducer activity | | substrate-specific transmembrane transporter activity | | transition metal ion binding | | transmembrane transporter activity | | transporter activity | | Process |
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| establishment of localization | | siderophore transport | | transport |
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| Gene Properties |
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| Blattner: | b4291 |
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| Gene Orientation | Counterclockwise |
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| Centisome Percentage: | 97.26 |
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| Left Sequence End | 4512376 |
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| Right Sequence End | 4514700 |
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| Gene Sequence: | >2325 bp
ATGACGCCGTTACGCGTTTTTCGTAAAACAACACCTTTGGTTAACACCATTCGCCTGAGC
CTGCTGCCGCTGGCCGGTCTCTCGTTTTCCGCTTTTGCTGCACAGGTTAATATCGCACCG
GGATCGCTCGATAAAGCGCTCAATCAGTATGCCGCACACAGCGGATTTACCCTCTCGGTT
GACGCCAGCCTGACGCGCGGCAAGCAGAGCAACGGCCTGCACGGCGATTACGACGTCGAG
AGCGGCCTGCAACAACTGCTGGACGGCAGCGGACTGCAGGTAAAACCGCTGGGAAATAAC
AGCTGGACGCTGGAGCCCGCGCCCGCACCAAAAGAAGATGCCCTGACCGTGGTCGGCGAC
TGGCTGGGTGATGCGCGTGAAAACGACGTATTTGAACATGCTGGCGCGCGTGACGTGATC
CGCCGTGAGGATTTCGCCAAAACCGGCGCAACCACCATGCGTGAGGTACTTAACCGCATC
CCTGGCGTCAGCGCGCCGGAAAACAACGGCACCGGCAGCCACGACCTGGCGATGAACTTT
GGCATCCGGGGCCTGAACCCGCGCCTCGCCAGCCGCTCGACCGTCCTGATGGACGGCATC
CCCGTCCCCTTCGCCCCTTACGGTCAGCCGCAGCTTTCACTGGCTCCCGTTTCGCTCGGC
AACATGGATGCCATTGACGTGGTACGCGGTGGTGGTGCGGTGCGTTACGGACCGCAGAGC
GTGGGCGGCGTGGTGAACTTTGTTACCCGTGCCATTCCGCAGGACTTTGGTATCGAGGCG
GGCGTGGAAGGTCAGCTCAGCCCAACCTCTTCACAAAACAACCCGAAAGAGACGCACAAC
CTGATGGTGGGCGGCACAGCGGACAACGGTTTTGGCACCGCGCTGCTCTACTCCGGCACG
CGCGGCAGTGACTGGCGCGAGCACAGCGCCACCCGCATCGACGACCTGATGCTGAAAAGC
AAATATGCGCCGGATGAGGTGCACACCTTCAACAGCCTGCTGCAATATTACGACGGTGAA
GCCGACATGCCCGGTGGCCTGTCTCGCGCGGATTACGACGCCGATCGCTGGCAATCCACC
CGCCCGTATGACCGCTTCTGGGGTCGTCGCAAGCTGGCGAGCCTGGGCTACCAGTTCCAG
CCAGACAGCCAGCATAAATTCAACATTCAGGGGTTCTACACCCAAACCCTGCGCAGCGGC
TACCTGGAGCAAGGCAAACGCATCACCCTCTCGCCGCGTAACTACTGGGTGCGCGGTATT
GAGCCACGCTACAGCCAGATCTTTATGATCGGCCCTTCCGCGCACGAAGTGGGCGTGGGC
TATCGCTATTTGAATGAATCAACGCATGAAATGCGTTACTACACCGCCACCAGCAGCGGG
CAGTTGCCGTCCGGCTCAAGCCCTTACGACCGCGATACGCGTTCCGGCACCGAGGCGCAC
GCCTGGTATCTGGATGACAAAATCGACATCGGCAACTGGACCATCACGCCGGGTATGCGT
TTCGAACATATCGAGTCATACCAGAACAACGCCATCACAGGCACGCACGAAGAAGTGAGC
TATAACGCACCGCTTCCGGCGTTGAACGTGCTCTATCACCTGACTGACAGCTGGAATCTT
TATGCAAACACTGAAGGCTCGTTCGGCACCGTACAGTACAGCCAGATTGGCAAGGCTGTG
CAAAGCGGCAATGTTGAACCGGAAAAAGCGCGAACCTGGGAACTCGGTACCCGCTACGAC
GACGGCGCGCTGACGGCGGAAATGGGGCTGTTCCTGATTAACTTTAACAATCAGTACGAC
TCCAACCAGACCAACGACACCGTCACTGCACGTGGCAAAACGCGCCATACCGGGCTGGAA
ACGCAGGCACGTTACGATCTGGGTACGCTAACGCCAACGCTTGATAACGTTTCCATCTAC
GCCAGCTATGCGTATGTGAACGCGGAAATCCGCGAGAAAGGCGACACCTACGGCAATCTG
GTACCATTCTCCCCGAAACATAAAGGCACGCTGGGCGTGGACTACAAGCCAGGAAACTGG
ACGTTCAATCTGAACAGCGATTTCCAGTCCAGCCAGTTTGCGGATAACGCCAATACGGTG
AAAGAGAGCGCCGACGGCAGTACCGGCCGCATTCCCGGCTTCATGCTCTGGGGCGCACGC
GTGGCGTATGACTTTGGCCCGCAGATGGCAGATCTGAACCTGGCATTCGGTGTGAAAAAC
ATCTTCGACCAGGACTACTTCATCCGCTCTTATGACGACAACAACAAAGGCATCTATGCA
GGCCAGCCGCGCACGCTGTATATGCAGGGGTCGTTGAAGTTCTGA |
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| Protein Properties |
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| Pfam Domain Function: | |
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| Protein Residues: | 774 |
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| Protein Molecular Weight: | 85321 |
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| Protein Theoretical pI: | 6 |
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| PDB File: | 1KMO |
| Signaling Regions: | |
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| Transmembrane Regions: | |
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| Protein Sequence: | >Fe(3+) dicitrate transport protein fecA
MTPLRVFRKTTPLVNTIRLSLLPLAGLSFSAFAAQVNIAPGSLDKALNQYAAHSGFTLSV
DASLTRGKQSNGLHGDYDVESGLQQLLDGSGLQVKPLGNNSWTLEPAPAPKEDALTVVGD
WLGDARENDVFEHAGARDVIRREDFAKTGATTMREVLNRIPGVSAPENNGTGSHDLAMNF
GIRGLNPRLASRSTVLMDGIPVPFAPYGQPQLSLAPVSLGNMDAIDVVRGGGAVRYGPQS
VGGVVNFVTRAIPQDFGIEAGVEGQLSPTSSQNNPKETHNLMVGGTADNGFGTALLYSGT
RGSDWREHSATRIDDLMLKSKYAPDEVHTFNSLLQYYDGEADMPGGLSRADYDADRWQST
RPYDRFWGRRKLASLGYQFQPDSQHKFNIQGFYTQTLRSGYLEQGKRITLSPRNYWVRGI
EPRYSQIFMIGPSAHEVGVGYRYLNESTHEMRYYTATSSGQLPSGSSPYDRDTRSGTEAH
AWYLDDKIDIGNWTITPGMRFEHIESYQNNAITGTHEEVSYNAPLPALNVLYHLTDSWNL
YANTEGSFGTVQYSQIGKAVQSGNVEPEKARTWELGTRYDDGALTAEMGLFLINFNNQYD
SNQTNDTVTARGKTRHTGLETQARYDLGTLTPTLDNVSIYASYAYVNAEIREKGDTYGNL
VPFSPKHKGTLGVDYKPGNWTFNLNSDFQSSQFADNANTVKESADGSTGRIPGFMLWGAR
VAYDFGPQMADLNLAFGVKNIFDQDYFIRSYDDNNKGIYAGQPRTLYMQGSLKF |
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| References |
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| External Links: | |
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| General Reference: | - Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
- Burland, V., Plunkett, G. 3rd, Sofia, H. J., Daniels, D. L., Blattner, F. R. (1995). "Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes." Nucleic Acids Res 23:2105-2119. Pubmed: 7610040
- Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
- Pressler, U., Staudenmaier, H., Zimmermann, L., Braun, V. (1988). "Genetics of the iron dicitrate transport system of Escherichia coli." J Bacteriol 170:2716-2724. Pubmed: 2836368
- Staudenmaier, H., Van Hove, B., Yaraghi, Z., Braun, V. (1989). "Nucleotide sequences of the fecBCDE genes and locations of the proteins suggest a periplasmic-binding-protein-dependent transport mechanism for iron(III) dicitrate in Escherichia coli." J Bacteriol 171:2626-2633. Pubmed: 2651410
- Van Hove, B., Staudenmaier, H., Braun, V. (1990). "Novel two-component transmembrane transcription control: regulation of iron dicitrate transport in Escherichia coli K-12." J Bacteriol 172:6749-6758. Pubmed: 2254251
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