Arginine exporter protein ArgO (P11667)

Identification
Name:Arginine exporter protein ArgO
Synonyms:Not Available
Gene Name:argO
Enzyme Class:Not Available
Biological Properties
General Function:Involved in amino acid transport
Specific Function:Involved in the export of arginine. Important to control the intracellular level of arginine and the correct balance between arginine and lysine. May also be involved in the export of canavanine (a plant-derived antimetabolite)
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Transports:
Transport References:
  • Orth, J. D., Conrad, T. M., Na, J., Lerman, J. A., Nam, H., Feist, A. M., Palsson, B. O. (2011). "A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011." Mol Syst Biol 7:535. Pubmed: 21988831
Metabolites:
ECMDB IDNameView
ECMDB21225Hydrogen ionMetaboCard
ECMDB00517L-ArginineMetaboCard
ECMDB00182L-LysineMetaboCard
GO Classification:
Component
cell part
integral to membrane
intrinsic to membrane
membrane
membrane part
Process
amine transport
amino acid transport
establishment of localization
transport
Gene Properties
Blattner:b2923
Gene OrientationCounterclockwise
Centisome Percentage:66.09
Left Sequence End3066195
Right Sequence End3066830
Gene Sequence:
>636 bp
ATGAATAAAGCAAAACGCCTGGAGATCCTCACTCGCCTGCGTGAGAACAATCCTCATCCC
ACCACCGAGCTTAATTTCAGTTCGCCTTTTGAATTGCTGATTGCCGTACTGCTTTCCGCT
CAGGCGACCGATGTCAGTGTTAATAAGGCGACGGCGAAACTCTACCCGGTGGCGAATACG
CCTGCAGCGATGCTTGAACTGGGCGTTGAAGGGGTGAAAACCTATATCAAAACGATTGGG
CTTTATAACAGCAAAGCAGAAAATATCATCAAAACCTGCCGTATCTTGCTGGAGCAGCAT
AATGGCGAGGTTCCGGAAGATCGTGCTGCGCTTGAAGCCCTGCCCGGCGTAGGTCGTAAA
ACAGCCAACGTCGTATTAAACACTGCATTCGGCTGGCCGACTATTGCTGTCGACACGCAC
ATTTTCCGCGTTTGTAATCGTACTCAATTTGCGCCGGGGAAAAACGTCGAACAGGTAGAA
GAAAAGCTACTGAAAGTGGTTCCAGCAGAGTTTAAAGTCGACTGCCACCATTGGTTGATC
CTGCACGGGCGTTATACCTGCATTGCCCGCAAGCCCCGCTGTGGCTCTTGTATTATTGAA
GATCTTTGTGAATACAAAGAGAAAGTTGACATCTGA
Protein Properties
Pfam Domain Function:
Protein Residues:211
Protein Molecular Weight:23175
Protein Theoretical pI:10
Signaling Regions:
  • None
Transmembrane Regions:
  • 1-21
  • 37-57
  • 68-88
  • 111-131
  • 147-167
  • 179-199
Protein Sequence:
>Arginine exporter protein ArgO
MFSYYFQGLALGAAMILPLGPQNAFVMNQGIRRQYHIMIALLCAISDLVLICAGIFGGSA
LLMQSPWLLALVTWGGVAFLLWYGFGAFKTAMSSNIELASAEVMKQGRWKIIATMLAVTW
LNPHVYLDTFVVLGSLGGQLDVEPKRWFALGTISASFLWFFGLALLAAWLAPRLRTAKAQ
RIINLVVGCVMWFIALQLARDGIAHAQALFS
References
External Links:
ResourceLink
Uniprot ID:P11667
Uniprot Name:ARGO_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:1742691
Ecogene ID:EG11159
Ecocyc:EG11159
ColiBase:b2923
Kegg Gene:b2923
EchoBASE ID:EB1148
CCDB:ARGO_ECOLI
BacMap:16130824
General Reference:
  • Alefounder, P. R., Perham, R. N. (1989). "Identification, molecular cloning and sequence analysis of a gene cluster encoding the class II fructose 1,6-bisphosphate aldolase, 3-phosphoglycerate kinase and a putative second glyceraldehyde 3-phosphate dehydrogenase of Escherichia coli." Mol Microbiol 3:723-732. Pubmed: 2546007
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Nandineni, M. R., Gowrishankar, J. (2004). "Evidence for an arginine exporter encoded by yggA (argO) that is regulated by the LysR-type transcriptional regulator ArgP in Escherichia coli." J Bacteriol 186:3539-3546. Pubmed: 15150242